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Alzheimers Drugs
Last lecture exam 3
8
Medical
Professional
02/16/2013

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Cards

Term
Memantine
Definition
Partial NMDA receptor antagonist (binds in open position)

May produce some agitation

RENAL AND PREVENT COGNITIVE DECLINE
Term
Donepezil
Definition
Cholinesterase inhibitor

May cause Nause, vomiting, diahrrea, headache, bradycardia

CYP450, LONGEST T1/2
Term
Galantamine
Definition
Cholinesterase inhibitor and stimulates nAChRs

Nausea, vomiting, diahrea, headache bradycardia

METABOLIZED CYP450
Term
Rivastigmine
Definition
Cholinesterase inhibitor

May cause Nause, vomiting, diahrrea, headache, bradycardia
Term
Tacrine
Definition
Cholinesterase inhibitor

May cause Nause, vomiting, diahrrea, headache, bradycardia

PLUS HEPATOXIC AND CYP450
Term
Cholinergic hypothesis
Definition
Nicotinic receptor decline in hippocampus

Increasing AcH alieviates symptoms
Term
Excitoxicity hypothesis
Definition
glutamate primary excitory neurotransmitter CNS

Prunes dendritic trees therefore neurotoxic
Term
ApoE
Definition
Alzheimer risk factor other than familial APP and trisomy 21
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