IV, short duration

non-selective, reversible

-vasodialate (decr TPR, BP) -> reflex tachycardia

-pre-op pheochromocytosis

-HTN in ER

-shock (blocks reflex vasoconst.->maintain perfusion)

-histamine release (bad if ulcer)

peptic ulcer disease

-orthostatic hypertension

-rashes

-reverse w/ phenylepherine

IV or PO, long duration

non-selective, irreversible

-pre-op & manage pheochromocytosis

-Raynaud's (& other vascular diseases)

-no histamine

-no GI (no cholinergic effect)

-sedation (CNS)

-reverse w/ phenylepherine

prazosin

terazosin

doxazosin

tamsulosin

PO, long duration; liver metabolize

a1 selective, reversible

-anti-HTN [decr chol, TG & incr HDL]

-BPH (only manage)

-first dose syncope (prazosin)

adrenergic neuronal blocker

-competes for tyrosine hydroxylase (false nt)

-not used clinically (quick tolerance)

guanethidine

guanadrel