Term
| What Ab's are responsible for an allergic response? |
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Definition
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Term
| What mediator is responsible for eosinophil activation? |
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Definition
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Term
| What is the difference between TH1 and TH2 responses? |
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Definition
TH1 is nonallergenic
TH2 is allergenic |
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Term
| What is the difference between the 2 signals of IgE synthesis? |
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Definition
The first signal: Through IL-4 initiates transcription of IgE
2nd signal: activates recombinase and removes IgG and IgM replacing it with IgE (delivered through activation CD40 B-cells) |
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Term
| What is the MOA of Xolair (omalizumab)? |
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Definition
| Interferes with the activation of IgE activation of mast cells and basophils. |
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Term
| What is the principle constituent of granules? |
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Definition
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Term
| What is the major lipid mediator (econasoid) product of eosinophils? What does it do? |
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Definition
| LTC4; contractor of airway smooth muscle. |
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Term
| What is present in all mast cell granules? |
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Definition
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