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AExam5 part 1
Reproductive and Musculoskeletal disorders
67
Biology
Graduate
12/16/2012

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Term
Primary dysmenorrhea
Definition
Pt has always had painful menstruation associated with release of excessive prostaglandins in ovulatory cycles.
Not associated with pelvic disease
Term
Secondary dysmenorrhea
Definition
Related to pelvic pathology.
New onset pain.
examples: Endometriosis, pelvic adhesions, PID, adenomyosis
Term
Primary amenorrhea
Definition
Failure of menarche and the absence of menstruation by age 14 without the development of secondary sex charcteristics or by age 16 regardless of the presence of secondary sex characteristics.
Term
Secondary amenorrhea
Definition
The absence of menstruation for a time equivalent to 3 or more cycles, or 6mo. in women who have previously menstruated.
May normally occur during first year of menarche, with pregnancy, lactation, or during perimenopause.
Term
Dysfunctional uterine bleeding (DUB)
Definition
Any menstural irregularity or abn. bleeding pattern.
Dx of DUB is made once disease has been ruled out.
Anovulatory DUB is characterized by unpredictable and variable bleeding in terms of amount and duration.
Term
Polycystic ovary syndrome (PCOS)
Definition
Cause unknown however,hyperinsulinemia causes androgens excess, anovulation, and pathogenesis of PCOS.
Associated with HTN, dyslipidemia, and hyperinsulinemia.
Approx 40% women obese, 20% asymptomatic (silent skinny), 30% develop DM II by age 30
Weight gain worsens sx, whereas weight loss may ameliorate some symptoms.
Term
DX of PCOS requires at least 2 of the following
Definition
Oligo-ovulation (few ovulatory cycles with peroids of amenorrhea)
Hyperandrogenism- elevated male hormone
Clinical signs of hyperandrogenism Polycystic ovaries- do not have to be present to dx with PCOS, can have 2 of the others and no cysts.
Term
Squelae of PCOS
Definition
Type II DM
CV disease
Endometrial carcinoma
Term
Pelvic inflammatory disease (PID)
Definition
Infection involving any organ or a combination of organs of the upper genital tract (uterus, fallopian tubes, or ovaries), or in its most severe form, the entire peritoneal cavity.
Most commonly caused by STI's that have traveled from the vagina.
Most major cases are polymicrobial, not just one source like GC or Chlam.
After one episode of PID, 15-20% of women develop long term squelae, such as infertility, ectopic pregnancy, chronic pelvic pain, dyspareunia, pelvic adhesions.
Term
CM PID
Definition
range from asymptomatic to sudden severe abd pain with fever. Most start with Bilateral low abd pain that is dull and steady with gradual onset. Pain worse with walking, jumping, sex. May have dysuria or irregular bleeding SX more likely to develop during or immediately after menstruation.
Term
Leiomyoma
Definition
aka: uterine fibroids
Benign smooth muscle tumors in the myometrium.
Many women are asymptomatic.
Estrogen increases size, so size changes during menstural cycle.
Term
Endometriosis
Definition
Presence of functioning endometrial tissue outside the uterus.
ectopic tissue responds to the hormonal fluctuations of the menstrual cycle.
Cause unknown but theories include: implantation of cells during retrograde menstruation,possibly autoimmune, genetic predisposition present.
Term
CM of Endometriosis
Definition
primarily infertility and pain that worsens progressively.
Term
Galactorrhea
Definition
Production of milk in a person who has no known cause for milk production.
Can occur in men.
Causes: Prolactinoma (pituitary tumor), Med side effect (birth control), persistent stimulation of nipples.
Term
Gynecomastia
Definition
Over development of breast tissue in males.
35% males will have at some point.
Usually in adolescents (testosterone has not caught up with estrogen levels) and in men >50 (testosterone levels low).
Marijuana use increases incidence.
Term
Functional uterine cysts
Definition
Follicular (before ovulation) and Corpus Luteum (after ovulation)cysts.
Benign, cause no harm only occasional pain.
most cysts are this kind.
Term
Ovarian Cyst
Definition
Egg not released so fluid not reabsorbed.
Can cause pain and delay in menstural bleeding.
Term
Adenomyosis
Definition
Type of uterine fibroid.
Endometrial tissue in myometrium.
Often asymptomatic.
Term
Dermoid Cyst
Definition
Ovarian teratomas that contain elements of all three germ layers.
Pre-cancerous, benign but potential to become malignant **Should be removed**
May contain bone,hair,skin,muscle,...
Term
Forms of pelvic floor relaxation
Definition
Cystocele
Urethocele
Rectocele
Enterocele
Uterine Prolapse
Term
Cystocele
Definition
Decent of a portion of the post. bladder wall and ant.vaginal wall into the vaginal canal.
Causes stress incont.
Term
Urethocele
Definition
sagging of the urethra commonly associated with women who have cystoceles and especially with urinary stress incontinence.
Term
Rectocele
Definition
Bulging of the large intestine into the posterior vagina
Term
Enterocele
Definition
Herniation of the rectouterine pouch into the rectal-vaginal septum.
Term
Uterine Prolapse
Definition
Decent of the cervix or the entire uterus into the vaginal canal.
Term
Causes for Pelvic floor relaxation
Definition
NOT CAUSED BY CHILD BIRTH!!

Genetics
Poor muscle tone
Lack of exercise
Poor diet
Term
Benign prostatic hyperplasia (BPH)
Definition
Enlargement of the prostate that can compress the urethra and cause outflow obstruction.
80% of men will develop on or before 80yo.
25-30% will need surgery once they hit 50yo if they already have BPH.
Term
CM of BPH
Definition
Frequency
Retention
Weak stream
Hesitancy
Dribbling after voiding
Overflow incont.
Increased intra-abd pressure
Hydroureter, hydronephrosis
Bladder & kidney infection
Inc vol. retained urine can lead to diverticular outpouching of bladder wall
Term
Prostitis
Definition
An inflammation of the prostate.
Can happen at any age.
Is limited to the excretory ducts.
Term
3 types of Prostitis
Definition
Acute Bacterial- very painful, do not palpate. typically 30-50yo.
Chronic Bacterial- recurrent infxn with pathogenic bacteria.
Non-bacterial- caused by reflux of urine.
Term
CM Prostitis
Definition
Inability to empty bladder
Nocturia
Urinary Retention
Slow, small, narrow stream
Prostate very tender and enlarged
Term
Breast Cyst
Definition
Fluid filled
Singular in nature
Just in one breast
Can be painful even without hormone flucuations of peroid
Term
Fibrocystic changes of the breast
Definition
Benign nodularity and breast tenderness that comes and goes with the menstrual cycle.
Both breasts are lumpy, feel like marbles.
Multiple cysts
Most common type of benign breast lesion.
Term
Proliferative breast lesions WITHOUT atypia
Definition
Benign proliferation of ductal epithelium
EX: Epithelial hyperplasia, Sclerosing Adenosis, Complex sclerosing lesion, Papillomas.
Term
CM breast cancer
Definition
CP
reddened skin, warm, tender
dimpling of skin
nipple retraction, nipple discharge
pitting of skin (orange peel skin- peau d' orange)
ulceration
Term
Characteristics of breast CA nodule
Definition

"stuck", non-mobile irregular in shape

non-tender

Term
Chalmydia
Definition
Most common STI Bacterial, tx with antibiotics CM men-urethritis, epididymitis, proctitis. CM women-acte urethral syndrome, bartholinitis, cervicitis, cervical atypia, salpingitis.
Term
Gonorrhea
Definition
Bacterial, tx with antibiotics
A urethral infnx in men, urethrogenital infxn in women.
CM men-dysuria, spontaneous, profuse, mucopurulent discharge from the urthra, urethral itching.
CM women-dysuria, increased vaginal discharge, abnormal menses, dyspareunia, cervical friability, discharge from the Skene or Bartholin glands.
Term
Syphilis
Definition
Anaerobic Bacteria (spyrochete), tx with PCN Primary CM- chancre- eroded, painless, firm, hard lesion. Secondary CM-low grade fever, general malaise, sore throat, HA, lesions on palms of hands and bottom of feet. some wart lesions in perineum, vulva, and groin of women, inner thigh and anus of men and women. Latent CM- no physical symptoms Tertiary CM- severe skin, bone, and soft tissue lesions called gummas, aneurysms, heart valve insufficiencies and heart failure and may cause neurosyphilis.
Term
Trichomoniasis
Definition
Parasitic, tx with antibiotic
CM range from none to severe with some women reporting an increase in symptoms after their period which include vaginal discharge and internal pruiritus. Dyspareunia, dysuria, copious frothy malodorous gay-green secretions are often common.
Term
HSV, Herpes Simplex Virus
Definition
No cure, treat symptoms
CM- blisters that are painful and puritic.
Recurrent infections often have unilateral lesions.
Term
Cryptorchidism
Definition
One or both testes fail to descend into the scrotum.
Most common condition of the testes. Can be a delay, malformation, or mechanical problem.
Causes decreased fertility and increased risk for testicular CA by 30-50%
Term
Hydrocele
Definition
Collection of fluid in the tunica vaginalis.
16% newborns have.
Spontaneously resolves.
Term
Testicular Torsion
Definition
Rotation of testicle on vascular pedicle. Sudden & painful. Causes are spontaneous or trauma related. Must be corrected within 4-6hrs or testicle tissue death occurs.
Term
Occult fracture
Definition
cant be seen in x-ray, only on MRI.
common in hips.
hidden or not readily discernable.
cause:minor force or energy
Term
Segmented FX
Definition
Fracture with two or more segments
cause: direct or indirect moderate force.
Term
Impacted Fx
Definition
One end wedged into opposite end of inside fractured fragment. Bones pushed together from compression injury to distal fragment.
Term
Open Fx
Definition
Bone has broken through skin.
formally called compound fx.
Caused by significant trauma.
Term
Greenstick FX
Definition
Perforates one cortex and splinters the spongy body of the bone.
from bent bone
often only splinted, not casted.
Term
Oblique fx
Definition
45 degree fx to long axis of bone.
Cause: direct or indirect energy with angulation and compression.
Term
Spiral fx
Definition
encircles bone
cause: direct or indirect twisting with distal part held or unable to move.
Term
Pathologic fx
Definition
A break at the site of a preexisting abnormality, usually by force that would not fracture a normal bone. Any disease process that weaknens a bone (especially the cortex) predisposes the bone to pathological fracture.
Term
Stress fx
Definition
Micro fractures from overuse.
Occurs during athletics
Often not splinted, just rest to heal.
Term
Osteoporosis
Definition
"Porous bone"
mass or bone density is decreased and the structural integrity of the bone is impaired.
More common in caucasian but affects all races.
Excessive phosphorous intake (soda) increases risk along with excessive caffeine, ETOH, and nicotine.
Major risk is fractures.
Term
Iatrogenic Osteoporosis
Definition
caused by prologned steroid use
EX: asthma patients
Term
CM Osteoporosis
Definition
Bone deformity
pain
Fracture
Kyphosis from vertebral compression leads to decreased height.
Term
Osteo Arthritis (OA)
Definition
AKA DJD (degenerative joint disease).
Classified as inflammatory joint disease.
Affects both men and women but women more severly affected.
Usually people >40yo, after 55yo more females than males.
Athletes develop sooner than non-athletes.
Obesity is major risk factor.
Glucosamine & condrotin shown to dec pain and slow progression.
VIT D shown to reduce risk of fx in older people **by increasing balance and decreasing risk of fall**
Term
CM OA
Definition
ASYMETRICAL pain and stiffening in one or more joints, usually weight bearing joints.
Decreased ROM
Enlargement & bulging of joint contour.
Term
Heberdene nodes
Definition
swelling at distal joints in hands.
Associated with OA
Term
Bouchard nodes
Definition
Swelling at proximal joints in hands.
Associated with OA
Term
Rheumatoid arthritis (RA)
Definition
Systemic inflammatory autoimmune disease associated with swelling and pain in multiple joints.
Wide spread connective tissue damage.
More women than men
Cause unknown, likely genetic interaction with inflammatory mediators.
Epstein Barr Virus plays a role.
Term
Joints commonly affeced by RA
Definition
metacapophalangeal
proximal interphalangeal
wrists of both hands
ALWAYS SYMETRIC!!
Term
CM of RA
Definition
Begins with general systemic manifestations of inflammation including fever, fatigue and weakness and anorexia, weight loss, generalized aching and stiffness, joints become more painful, tender and stiff.
Loss of range of motion
SQ nodules on hands, arms, shins, not in joints.
Ulnar drift- fingers pronate back toward ulna "swan hand".
Term
Gout
Definition
Syndrome caused by either excessive production of or hypoexcretion of uric acid leading to hyperurecemia. Uric acid crystalizes are deposited in connective tissues throughout the body. This causes acute, painful inflammation of the joint, known as gouty arthritis. With time, crystal deposition in SQ tissues causes the formation of small, white nodules, or tophi, that are visible through the skin. Crystals in kidneys lead to renal stones and renal failure.
Term
CM Gout
Definition
Can have elevated levels and be asymtpomatic.
Renal disease
Recurrent attacks of monoarticular arthtiris (Great toes is most common).
Deposits of tophi in and around joints (third and chronic stage).
Trauma is the most common aggravating factor.
Term
Fibromyalgia
Definition
Chronic musculoskeletal syndrome.
Primarily diagnosed by exclusion.
80-90% of individuals affected are women and the peak age is 30 to 50 years.
The most common precipitating factors include: flulike viral illness,wide spread candida infection after mass antibiotic use (some severe illness), physical trauma, emotional trauma.
RA and SLE are commonly associated with fibromyalgia.
More common than RA but much less severe.
Term
CM Fibromyalgia
Definition
Chronic pain
Fatigue
Pain in the 18 tender points
The only reliable finding on examination is the presence of 11/18 of the tender points.
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