Term
| What are the possible hemotologic toxcities? |
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Definition
*Myelosuppresion
-Most frequent
-Most common dose limiting toxcitiy
*Destruction of WBCs, Plt, and RBCs leading to:
-Leukopenia
-Thrombocytopenia
-Anemia
*Occurs around 10-14 days after first round of treatment
*Cell regrowth 24-48 days |
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Term
| What are the four types of pulmonary toxicites associated with chemotherapy? |
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Definition
*Chronic Pneumonitis & Pulmonary Fibrosis
*Pulmonary HTN
*Acute Hypersensitivity Reaction
*Non-cardiogenic pulmonary edema |
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Term
| What is the most common pulmonary toxicity that is irreversible with s/s of DOE, non-productive cough, fatigue, hypoxemia? |
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Definition
| *Chronic Pneumonitis and Pulmonary Fibrosis |
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Term
| Which drug is associated with lung toxicity? |
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Definition
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Term
| What are possible GI toxicities? |
|
Definition
*Stomatitis
*Mucositis
*Intestinal desquamation
*Diarrhea or constipation
*N&V |
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Term
| What cardiac toxicities can occur with chemotherapy? |
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Definition
*ECG changes and life threatening arrhythmias
*Pericarditis, pericardial effusion
*Myocardial Ischemia
*Cardiomyopathies
*CHF
*Commonly seen with Doxurubicin |
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Term
| What drug is associated with cardiac toxicities? |
|
Definition
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Term
| What Renal toxicities are present with chemo? |
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Definition
| *ATN, ARF, hemorrhagic cystitis |
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Term
| What liver toxicities are present with chemo? |
|
Definition
*Hepatic fibrosis
*Cirrhosis |
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Term
| What drug is associated with renal toxicity? |
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Definition
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Term
| What neurotoxicities are associated with chemo? |
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Definition
*N&V
*Neuropathies and paresthesias
-Common with Cisplatin and Vincristine
*Cranial nerve toxicities
*Muscle pain and weakness
*Sensory impairment such as otoxoicity and retinopathy |
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Term
| What is important for combination chemotherapy? |
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Definition
*Use of different agents that act on different cycles of the DNA synthesis
*Drugs with different MOA
*Drugs with different dose-limiting toxicities
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Term
| What is the goal of combination chemotherapy? |
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Definition
| *To administer the largest possible doses of each drug to achieve maximal cell kill |
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Term
What is the MOA of Tyrosine Kinase Inhibitors?
Ex: Imatinib (Gleevec), Traztuzumab (Herceptin) |
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Definition
Inhibitor specifically blocks the action of protein kinase
*Interferes with cell communication and growth thus preventing tumor growth
*Inhibits tyrosine kinase enzymes instead of non-specifically inhibiting dividing cells |
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