Term
|
Definition
PARTICLES: liposomes and microspheres
[control drug release and used for targetting]
SOLUBLE MACROMOLECULES: antibodies and other proteins(albumin) |
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Term
| rate of transfer through polymer |
|
Definition
|
|
Term
polymer thickness is_______
Are is area________ |
|
Definition
length
in contact with the environment |
|
|
Term
3 math models
zero order
1st order
square root of time (t^-1/2) |
|
Definition
zero order= true controlled release
1st order= release rate proportional to mass of active ingredient contained in device
square root of time release=release rate linear with square root of time remains finite as the sys approaches exhaustion |
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Term
|
Definition
reservoir= diffusion from sat sol controlled by polymer membrane
matrix= where uniformly dispersed drug diffuses through polymer matrix. drug leaves creating ghost(sq rt of time release) |
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Term
|
Definition
osmotic=rx released nearly zero order.drug forced thru laser driled hole
[osmotic pressure governs release]
swelling= drug uniformly dispersed in a polymer matrix.as matrix increases pore size does too |
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Term
|
Definition
-bioerodible polymer
-matrix erodes
-drug diffuses thru matrix or released as matrix erodes |
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Term
|
Definition
depo injectable prodrug
[lipophilic drugs,slowly release/dissolve]
|
|
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Term
|
Definition
1-125 micrometers in diameter
have bioerodible matrix sys to prolong drug release
ex: Lupron Depot
[microspheres breaks down to polylactic acid and polyglycolic acid] |
|
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Term
|
Definition
subQ
poor hemoperfusion
rich in fat
|
|
|
Term
| membrane controlled (reservoir) polymer implants |
|
Definition
-ZERO ORDER RELEASE
-REQUIRE SURGICAL INSERTION/SURGICAL REMOVAL
EX:NEXPLANON=(Birth contr up to 3 yrs) |
|
|
Term
|
Definition
in NEXPLANON birth control
makes implant radio opaque |
|
|
Term
Histrelin acetate implants (polymer implant)
-Suprellan LA(for central precocious puberty)
-Vantas(for the palliative Tx of advanced prostate cancer) |
|
Definition
non biodegradable implant= HYDRON(yr of steady release)
|
|
|
Term
| Probuphine (polymer implant) |
|
Definition
for opioid dependence
buprenorphine and ethylen vinyl acetate(EVA) |
|
|
Term
| Ethylene Vinyl Acetate (EVA) |
|
Definition
| for implant slowly degrades and releases drug |
|
|
Term
| Bioerodible matrix implants (polymer degrades) |
|
Definition
Zoladex (10mm long,1mm diameter)
[inserted subQ in abdomen]
water penetrates and hydrolyzes polymer
(available as 1 or 3 month products) |
|
|
Term
Gliadel Wafer (bioerodible intracranial implant) ewwwe
[image] |
|
Definition
made of microspheres
bioerodible matrix
ex: CARMUSTINE=delivers 1000 times more than thru IV admin |
|
|
Term
| mechanical implants use ____ to deliver meds |
|
Definition
positive pressure
[made of titanium for biocompatability]
ex:SYNCHROMED II = rotating cams squeeze tubing as they rotate and pushes out fluids. reservoir refilled thru a septum
|
|
|
Term
| Codman 3000 Constant Flow Infusion Sys |
|
Definition
This uses a drug-fluid containing bellows compressed by propellant to force drug fluid out through a flow restrictor
MECHANICAL IMPLANT |
|
|
Term
Insulin Pumps in U.S. (external Infusion pumps)
-programmed based on pt specific needs
-basal insulin delivery plus bolus dose prn |
|
Definition
ANIMAS
ASANTE
TANDEM
OMNIPOD
MINIMED |
|
|
Term
| Minimed real time paradigm revel insulinpump sys |
|
Definition
| has continuous glucose monitoring w/ sensor |
|
|
Term
| First artificial pancreas _______approved in 2016 |
|
Definition
Minimed 670G
only automates background insulin
shuts off if blood glucose drops too low
requires manual bolus |
|
|
Term
| Elastomeric infusion pumps |
|
Definition
disposable pump uses elastic membrane for fluid delivery
popular ambulatory use
not as accurate as electronics |
|
|
Term
| Spatial control of drugs thru______&_______ |
|
Definition
| Liposomes and Albumin nanoparticles |
|
|
Term
|
Definition
Doxorubicin liposomes-IV for Kaposis sarcoma
water soluble
less cardiac toxicity due to tumor site specificity |
|
|
Term
| _______ are problems for Liposomes avoided by combining with PEG for protection |
|
Definition
MPS
Mononuclear Phagocyte System |
|
|
Term
| Ambisome(liposome product) |
|
Definition
Amphotericin B liposomes-antifungal product
lipid soluble
less nephrotoxicity |
|
|
Term
Albumin nanoparticles
nanometer proportions |
|
Definition
Abraxane= injectable susp(paclitaxel)
[very lipophilic]
formulated with the surfactant Cremaphor EL and 50% alcohol
Paclitaxel can cause reaction requiring glucocorticoid admin...not needed w/ abraxane |
|
|
Term
|
Definition
ONTAK-Denileukin Diftitox= recomb protein combining interleukin-2 and diptheria toxin
[targets cells w/ IL-2 receptors to deliver toxine] |
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