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Adrenergics
Adrenergics for MCG 2009
18
Pharmacology
Graduate
09/29/2009

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Cards

Term
Phenylephrine
Definition
alpha1 agonist
not substrate for COMT
tx: nasal decongestant, hypotension
Term
methoxamine
Definition
alpha1 agonist
not substrate of COMT or MAO
tx: hypotension
Term
clonidine
Definition
alpha2 agonist
tx: hypertension
Term
dobutamine
Definition
beta1 agonist
tx: CHF
Term
terbutaline and albuterol
Definition
beta2 agonist
bronchodilator in asthma or copd related bronchoconstriction
Term
amphetamine
Definition
indirect agonist
release of NE
increases alertness, decreases fatigue, enhances physical and mental performance
Term
metaraminol
Definition
mixed adrenergic agonist
stimulates directly
replaces NE in storage
tx: hypotension
Term
ephedrine
Definition
mixed adrenergic agonist
direct stimulation
induces NE release
appetite suppressant
Term
pheoxybenzamine
Definition
alpha adrenergic antagonist
irreversible block
tx: pheochromocytoma
Term
phentolamine
Definition
adrenergic alpha antagonist
non-selective, competitive alpha
ED, pheochromocytoma
Term
prazosin
Definition
adrenergic alpha antagonist
selective for a1
inhibits PDE
tx: htn, improves urinary flow
first dose phenomenon
Term
propranolol
Definition
beta antagonist
tx: htn, mi, glaucoma, hyperthyroid
not for asthmatics
Term
metopralol
Definition
beta1 antagonist
decreases HR, contracility
tx: htn
safe for asthmatics
Term
guanethidine
Definition
indirect adrenergic antagonist
depletes NE from presynaptic
tx: htn, dilates arterial and venous beds
Term
reserpine
Definition
irreversible inhibition of dopamine and NE uptake into storage vesicles
tx: mild to moderate htn
depression, suicide, nightmares, sedation
Term
alpha-methyldopa
Definition
false NE
tx: htn, but effect is CNS
good for htn pregnant
s/e: sedation, drowsiness, orthostatic hypotension
Term
methyl tyrosine
Definition
inhibits NE synthesis
tx: pheochromocytoma
Term
cocaine
Definition
inhibits uptake 1
local anesthetic
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