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Details

Adrenergic Receptor
types, mechs, selectivities
14
Medical
Graduate
08/27/2013

Additional Medical Flashcards

 


 

Cards

Term
a1
Definition

 

vasc SM

---contracts

     

pupillary dilator muslce

---contracts (mydriasis)

     

Term
a2
Definition

adrenergic and cholinergic nerve terminals

   --- inhibits NT release

 

some vasc SM

   --- contracts

Term
B1
Definition

Heart

   --- stims rate and force

 

juxtaglomerular cells

   --- stims renin release

Term
B2
Definition

respiratory, uterine, and vasc SM

---relaxes

 

somatic motor nerve terminals (voluntary muslce)

---causes tremor

Term
dopamine1
Definition

renal and other splanchnic bl vessels

---relaxes (reduces resistance)

Term
dopamine2
Definition

nerve terminals

---inhibits AC

Term
a1 mech
Definition
Gaq-->PLC-->IP3+DAG-->inc Ca release from sarco
Term
a2 mech
Definition

Gai--| AC-->dec cAMP-->dec Ca and dec NT release

 

or

 

Gai--| AC-->so, no PKA--> so, activated MLCK--> SM constriction

Term
B1 mech
Definition
Gas-->AC-->cAMP-->PKA-->inc Ca
Term
B2 mech
Definition
Gas-->AC-->cAMP-->PKA--| MLCK-->dec contraction
Term

a1 selectivity

Definition
EPI >= NE >> ISO
Term

a2 selectivity

Definition
EPI >= NE >> Iso
Term

B1 selectivity

Definition
Iso > EPI = NE
Term

B2 selectivity

Definition
Iso > EPI >> NE
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