Term
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Definition
| produce effect by activiating the adrenergic receptors, leads to similar responses as activating the SNS, therefore often referred to as sympathomimetics. FIGHT OR FLIGHT |
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Term
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Definition
+ increases force of contraction
- decreases force of contraction (relax) |
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Term
| 5 main receptors for adrenergic |
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Definition
| Alpha1, Alpha 2, Beta1, Beta2, Dopaminergic |
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Term
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Definition
| profuse body wide vasoconstriction, mydriasis. eyes, blood vessels (vasoconstriction), male sex organs (ejaculation), prostatic capsule (contration), bladder (contraction) |
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Term
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Definition
| hypotension, homeostatis, nasal decongestion, adjunt to local anesthesia, mydriasis |
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Term
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Definition
| hypotension, analgesia (pain relief) |
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Term
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Definition
| stim. in periphery has little consequences. stim in CNS will lead to sympathetic outflow tot he heart and the blood vessel. Will block Alpha1- producing a vasodilation state. DROPS BP watch closely. will eliminate Norepy. |
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Term
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Definition
| receptors in heart. inc HR, inc. pupil constriction |
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Term
| Primary uses for Beta1 activation |
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Definition
| cardiac arrest, heart failure (pump failure)- need to pump harder and faster. shock |
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Term
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Definition
| in lungs. rescue inhalers. dilation of uterine muscle, relaxtion of uterine muscle, activation of gylcogenoylsis, |
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Term
| primary uses for Beta2 activation |
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Definition
| asthma, delay of pre term labor. |
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Term
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Definition
| making new glucose, conversion of glycogen to glucose within the liver. raises blood sugar, can cause temp diabetic situation. |
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Term
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Definition
| mimics adrenaline. stimulates A1, A2 (peripherally), B1 (needs cardiac contraction), B2 |
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Term
| main uses for epinephrine |
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Definition
| hypotension, mydriasis, bronchodialtion, in conjunction with local anesthetics and anaphylactic shock |
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Term
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Definition
| hyptertensive crisis, cardiac dysrhythmias, angine pectoris, hyperglycemia (due to B2) |
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Term
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Definition
| Levophed. very strong. stim A1, A2, B1- very sim to epi. |
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Term
| main uses for norepinephrine |
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Definition
| severe hypotension (causes profuse vasocontriction), utilized during cardiac arrest, most spec. with hypotension with dec organ perfusion (shock) |
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Term
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Definition
| similar to epi. does not cause hyperglycemia (doesnt activate B2), can cause loss of limb due to profuse vasoconstriction over 4 hrs "leave em dead" |
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Term
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Definition
| receptor in kidneys. Dopamenergic, B1, A1. harsh drug. |
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Term
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Definition
| 0.5 mcg-2mcg dopamenergic- increases renal perfusion and thereby increases UO |
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Term
| moderate dose of dopamine |
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Definition
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Term
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Definition
| greater than 10mcg (some B1 until ~15mcg then strictly A1) potent vasoconstrictor |
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Term
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Definition
| strong but not as strong as mod dose dopa. B1, used mainly for heart failure |
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Term
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Definition
| tachycardia, exacerbation (make worse) of heart failure |
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Term
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Definition
| block A1 response, cause elicit vasodilation. utilized for essential hypertension, pheochromocytoma, raynauds diease. |
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Term
| adrenergic antagonists SE/AR |
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Definition
| orthostatic hypotension, reflex tachycarida, nasal congestion, inhibition of ejaculation. |
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Term
| adrenergic antagonists medications |
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Definition
Prozosin (Minipress) used for HTN
Terazosin (Hytrin) HTN, BPH
Doxazosin (Cardura) HTN, BPH
Phentolamine (Regitine) pheochromocytoma, prevention of tissue necrosis following extravasation of caustic medications to the subcutaneous tissue (Dopamine, Norepi) |
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Term
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Definition
| nictonic receptors being activated, dosage in smoking is low and will activate, higher doses cause nicotonic blockade (treated as a poison), crosses cell memb easily and is widely distributed. easily crosses placenta and mammary barriers. causes rapid and profuse release of norepi in body. |
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Term
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Definition
| depends on delivery. smoking 90-98% in pulmonary system, chew/cigar in oral cavity |
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Term
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Definition
| + chronotropic, inc BP, inc cardian work. |
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Term
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Definition
| dec gastric secretions, appetite sppresants, inc tone and motility of GI smooth muscle, can promote vomitting. |
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Term
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Definition
| stimulant. tremors, facilitates memory, improves cognitive function, reduces aggresion and suppresses appetite |
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