Term
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Definition
Uses: bradycardia, eye disorders, pre-anesthesia, intestinal hypermotility/tonicity, muscarinic agonist poisoning
MOA: muscarinic ACh antagonism
Adverse Effects: anticholinergic effects, hyperthermia (reduced sweating), raised IOP, CNS excitement
Drug Interactions: antihistamines, antipsychotics, TCAs, phenothiazines
NIs: route: IV, IM, SQ, PO |
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Term
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Definition
Uses: urge incontinence
MOA: muscarinic (M3) receptor blocker, inhibits urge to void
Adverse Effects: anticholinergic effects, and confusion
NIs: extended release reduces SEs |
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Term
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Definition
Uses: anaphylactic shock, cardiac arrest (to control superficial bleeding), anesthetic delay
MOA: stimulates A1, A2, B1, and B2
Adverse Effects: HTN, dysrhythmias, angina, necrosis following extravasation, and hyperglycemia
Drug Interactions: MAOIs, TCAs, gen anesthetics, alpha & beta adrenergic blocking agents
NIs: Route: topical, inhaled, parenteral |
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Term
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Definition
Uses: HTN, angina, cardiac dysrhythmias, MI, and HF
MOA: 2nd gen Beta-1 antagonist (cardioselective)
Adverse Effects: bradycardia, decreased CO, AV block, rebound cardiac excitation
NIs: lipid soluble, first pass effect, hepatic metabolism, renal excretion; route: PO, IV |
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Term
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Definition
Uses: htn
MOA: A1 antagonist
Adverse Effects: orthostatic hypotension, nasal congestion, ejaculation inhibition
NIs: Route: oral; baseline BP/BP monitoring; "first dose effect" hypotension; educate on hypotension; move slowly when necessary |
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Term
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Definition
Uses: HTN, severe pain
MOA: centrally acting selective A2 agonist
Adverse Effects: drowsiness, xerostomia, rebound HTN, constipation, impotence, gynecomastia, and adverse CNS effects
NIs: route: PO, transdermal; baseline BP and HR; embryotoxic; taken HS; transdermal: hairless, intact skin on upper arm or torso; withdraw meds slowly. |
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