Term
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Definition
1) B-cell encounters and binds to foreign peptide in lymph or blood. The peptide is internalized, processed, and presented on the surface by an MHC class II protein.
2) The MHC-peptide complex interacts with complementary receptors on a helper T-cell, activating it.
3) Cytokines from the activated helper T-cell activate the B-cell.
4) The activated B-cell begins to divide. Some daughter cells differentiate into plasma cells which produce large quantities of antibodies. |
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Term
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Definition
1) Antibodies coat free virus particles. The virus cannot bind to the host cell's plasma membrane.
2) The antibody-coated virus is recognized, phagocytized, and destroyed by a neutrophil or macrophage. |
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Term
| Dendritic Cells: Sampling Epitopes |
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Definition
1) Dendritic cell ingests peptide.
2) Enzyme complex inside cell breaks peptide into pieces.
3) Peptide pieces attached to MHC class I protein inside ER.
4) MHC-peptide complex is transported to the cell surface via the golgi.
5) The MHC class I protein presents the peptide on the cell surface. |
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Term
| Dendritic Cells: Activating T-Cells |
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Definition
1) T-cell receptor binds to peptide presented by MHC protein on surface of dendritic cell. Complex activation process begins, involving interactions among many proteins on the cell surfaces.
2) Activated CD8+ (Killer) T-cells multiply and differentiate. Effector (killer) T-cells that result leave nymph node and enter blood. |
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Term
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Definition
1) Cytotoxic (killer) T-cell makes contact with virus-infected cell and releases granules.
2) Molecules in the granules induce infected cell to self-destruct, killing the viral particles inside. |
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