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Acid Base Disorders
Acid Base Disorders
29
Pathology
Undergraduate 3
05/04/2014

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Term
Acid
Definition
H+ producing substance
Term
Base
Definition
H+ accepting substance
Term
Buffer
Definition
substance that can absorb excess H+ (acid) or OH- (base)
Term
Plasma Buffer System
Definition
proteins (- charge), such as Hgb, can bind with H+
(fast) phosphate (PO4-) can bind with H+
cellular ion exchange- can interchange H+ with K+
Term
Respiratory System as Buffer
Definition
(minutes to hours) lungs regulate retention or elimination of CO2 thru changes in rate of ventilation
Term
Renal System as Buffer
Definition
(hours to days) kidneys reabsorb more HCO3- or H+
excrete more HCO3- or H+
Term
pH NL
Definition
7.35-7.45
Term
pCO2 NL
Definition
35-45
Term
HCO3- NL
Definition
22-28
Term
Respiratory indicator
Definition
pCO2 (35-45)
Term
Metabolic indicator
Definition
HCO3- (22-28)
Term
Acidosis
Definition
decreased pH of arterial blood (<7.35)
systemic increase in H+ concentration or decrease in HCO3-
Term
Alkalosis
Definition
increased pH of arterial blood (>7.45)
systemic decrease in H+ concentration or increase in HCO3-
Term
Respiratory Acidosis Etio
Definition
anything depressing ventilation or gas exchange
depression of respiratory center, resp muscle disorder, lung disorders
Term
Respiratory Acidosis Initial ABGs
Definition
pH=low
pCO2=high
HCO3=normal
Term
Respiratory Acidosis Compensation
Definition
by the kidneys- retain more HCO3 or excrete more H+
Term
Respiratory Acidosis Compensated ABGs
Definition
pH= low side of normal
pCO2= high
HCO3= high (bring more base in --> increased HCO3)
Term
Respiratory Alkalosis Etio
Definition
hyperventilation (blow off more CO2)
panic attack, ventilator
Term
Respiratory Alkalosis Initial ABGs
Definition
ph=high
pCO2=low (blown off CO2)
HCO3=normal
Term
Respiratory Alkalosis Compensation
Definition
by the kidneys
excrete more HCO3- or retain more H+
Term
Respiratory Alkalosis Compensated ABGs
Definition
pH=high side of normal
pCO2=low
HCO3=low
Term
Metabolic Acidosis Etio
Definition
loss of base (HCO3-) or gain of acid (H+)
renal failure (kidneys unable to retain HCO3-)
lactic acidosis (muscle breakdown)
DB ketoacidosis (buildup of ketone acids)
diarrhea (lose intestinal HCO3-)
ingestion of acids (chemicals)
Term
Metabolic Acidosis Initial ABGs
Definition
pH=low
pCO2=normal
HCO3=low (loss of HCO3- or gain of H+)
Term
Metabolic Acidosis Compensation
Definition
by the lungs
hyperventilate to get rid of CO2
Term
Metabolic Acidosis Compensated ABGs
Definition
pH=low side of normal
pCO2=low
HCO3=low
Term
Metabolic Alkalosis Etio
Definition
loss of metabolic acids (prolonged vomiting), excess HCO3- intake (accidental poisoning)
Term
Metabolic Alkalosis Initial ABGs
Definition
pH=high
pCO2=normal
HCO3=high
Term
Metabolic Alkalosis Compensation
Definition
by the lungs
hypoventilate to retain more CO2
Term
Metabolic Alkalosis Compensated ABGs
Definition
pH=high side of normal
pCO2=high
HCO3=high
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