Term
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Definition
REVERSIBLE
potentiates ACh throughout the body, but used in
ophthalmologic settings (glaucoma) and to increase tone in bladder and GI after surgery or
postpartum. At high doses causes muscle paralysis (muscular fasciculation), can be a poison, or
an antidote against atropine poisoning.
Crosses BBB and can be used to counteract restlessness, tremors, confusion, ataxia, convulsions,
slurred speech and hallucinations caused by dextromethorphan abuse. “skittling”, “red devils”,
“rowbowing”, ”robo‐trippin |
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Term
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Definition
pseudocholinesterase
found in plasma, intestines, skin
Important in the metabolism of drugs such as succinylcholine
point mutations increase procaie
duration to days |
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Term
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Definition
REVERSIBLE STIGMINE
Synthetic version of physiostigmine but does not cross BBB
Anecdote to tubocurarine poisening
Improves myastinia gravis (Receptor Blocker) and Xerostoma
Also good to improve tone GI/Bladder |
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Term
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Definition
REVERSIBLE STIGMINE
Used in Tensilon Test to diagnose myasthenia gravis |
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Term
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Definition
IRREVERSIBLE ORGANOPHOSPHATE
Insect Spray crosses BBB.
Malthion = derivative used to treat headlice (metabolized quickly) |
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Term
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Definition
IRREVERSIBLE ORGANOPHOSPHATE
covalently binds to AchE esteratic site and inactivates it
Utilized for prolonged Tx Glaucoma |
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Term
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Definition
ORGANOPHOSPHATE ANECDOTE
- nucleophile stops aging and removes inhibitor
2PAM |
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Term
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Definition
Atropine
Scolopamine
2PAM
Pyridostigmine prophylaxis |
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