Term
3 types of protozan infxns |
|
Definition
ALT: amebiasis, leishmaniasis, Trypanosomiasis |
|
|
Term
Luminal Amebicides indicated for ASYMPTOMATIC intestinal infection |
|
Definition
-Diloxanide (B-CI during pregnancy) and Paramomycin |
|
|
Term
SE of diloxanide and Paramomycin |
|
Definition
|
|
Term
|
Definition
Chloroquinine and dehydroemitine |
|
|
Term
DOC for C.Diff, trichomoniasis and giardiasis |
|
Definition
Mixed Amebicide Metronidazole |
|
|
Term
Dont use in 1st trimester, METALLIC taste, 50% relapse rate. |
|
Definition
|
|
Term
|
Definition
|
|
Term
Ifxn that causes skin sore and affects the liver and spleen via sandflies (co-infxn with HIV common) |
|
Definition
|
|
Term
drug indicated for cutaneous and visceral leishmaniasis infxn |
|
Definition
|
|
Term
inhibits glycolytic enzymes and FA oxidation |
|
Definition
MOA of Sodium stibogluconate |
|
|
Term
prolonged QT and renal dysfunction |
|
Definition
SE of Sodium stibogluconate |
|
|
Term
Best broad spectrum Anti-fungal and used for visceral leismaniasis (liposomal/lipid form$$$) |
|
Definition
|
|
Term
|
Definition
|
|
Term
Drug to tx cutaneous Leishmaniasis (IM), Pneumocystic PNA in pt with sulfa allergy or african sleeping sickness |
|
Definition
|
|
Term
inhibits oxidative phosphorylation... can cause pain at injection shot or hypotension/tachycardia if giving IV |
|
Definition
|
|
Term
Infxn causing chancre at bite site, fever, HA, rash |
|
Definition
|
|
Term
American sleeping sickness and CHAGAS dz--> |
|
Definition
|
|
Term
African Sleeping Sickness caused by |
|
Definition
|
|
Term
Drug used to tx AFRICAN sleeping sickness that has a SE of a crawling sensation during admin. |
|
Definition
|
|
Term
Drug used to tx american sleeping sickness and DOC for chagas dz |
|
Definition
|
|
Term
caused superoxide radical toxicity to parasite and host |
|
Definition
|
|
Term
may cause delayed hypersensitivity, GI issues, neuro issues |
|
Definition
|
|
Term
pregnancy SAFE drug used to tx helminth (worm) infxn by inhibiting cholinesterase (Inc ACH--> paralysis) |
|
Definition
Pyrantal Pamoate (PP safe for Pregnancy) |
|
|
Term
drug used to tx helminth infsxn with Caution warnings during 1st trimester, if pt has IBS or liver dz |
|
Definition
|
|
Term
may cause GI or crytalluria/hematuria is used long term |
|
Definition
|
|
Term
Inhibits microtubule formation |
|
Definition
MOA of mebendazole and albendazole |
|
|
Term
broad spectrum anti-fungal NOT USED IN US |
|
Definition
|
|
Term
may cause alopecia and rash if used long term |
|
Definition
|
|
Term
anti-helminth drug that CANNOT be used in preggos, pt with renal or liver dz and may cause GI issues |
|
Definition
|
|
Term
|
Definition
Diethylcarbamazine citrate |
|
|
Term
may cause Mazzotti rxn (sev itching,, rash, tachy, HA) |
|
Definition
Diethylcarbamazine citrate SE |
|
|
Term
DOC for onchocerciasis and strongyloidiasis |
|
Definition
|
|
Term
May cause a mazzott LIKE rxn |
|
Definition
|
|
Term
|
Definition
|
|
Term
drug that tx tapeworm but should not be used with alcohol use |
|
Definition
|
|
Term
the only abx that DOES NOT induce resistance |
|
Definition
|
|
Term
mutations, transduction, transformation, conjugation |
|
Definition
|
|
Term
bacteriostatics blocking bacteriocidal agents |
|
Definition
|
|
Term
use of 2 abx has BETTER effect than each drug alone |
|
Definition
|
|
Term
disadv to using combined microbials for broader range |
|
Definition
kills intestinal flora, get superinfxn and fungal growth |
|
|
Term
Abx preventing folic acid synthesis |
|
Definition
|
|
Term
prevent cell wall synthesis in actively growing bacteria |
|
Definition
penicillin and cephalosporin |
|
|
Term
|
Definition
|
|
Term
30s- protein synthesis inhibitor |
|
Definition
aminoglycosides and tetracyclin |
|
|
Term
50s- protein synthesis inhibitor |
|
Definition
chlormphenicol and erythromycin |
|
|
Term
|
Definition
PAQC: penicillin, aminoglycosides, cephalosporin, quinolones |
|
|
Term
|
Definition
TEC: tetracyclines, erythromycin, chloramphenicol |
|
|
Term
IM admin given for G- infxn (binds 30S) |
|
Definition
|
|
Term
long acting, broadspectrum, bacterioSTATIC, DOC for PNA |
|
Definition
|
|
Term
may chelate bones and teeth or cause vestibular toxicity (N/V). dont give while baby's teeth are growing!! |
|
Definition
|
|
Term
last resort, broad spectrum, bacterioSTATIC used to treat a brain infxn |
|
Definition
|
|
Term
may cause GREY BABY SYNDROME (CI in newborns) |
|
Definition
|
|
Term
Used to tx G+ infn and can be combined with B-lactams or vanco |
|
Definition
|
|
Term
may cause Steven Johnson Syndrome |
|
Definition
|
|
Term
|
Definition
|
|
Term
2 drugs that combined, tx G+ (LAST RESORT) and become synergistically bacterioCIDAL |
|
Definition
dalfopristin and quinupristin |
|
|
Term
to tx G+ infxn, ONLY IF SEVER inxn so you dont build resistance |
|
Definition
|
|
Term
if you combine sulfonamide (S) and trimethromprim (S) they become |
|
Definition
|
|
Term
inhibitors of tetrahydrofolate synthesis used to tx UTIs and resp infxns |
|
Definition
STT: sulfonamides trimethoprim and co-trimoxazole |
|
|
Term
broad spectrum abx used to tx toxoplasmosis, IBD and conjunctivits. May cause stones and SJ syndrome |
|
Definition
|
|
Term
admin with folinic acid to prevent folate deficiency (MOA at difydrofolate reductase) |
|
Definition
|
|
Term
DOC- broadspectrum abx for UTI |
|
Definition
|
|
Term
broadspecrtrum abx used in emprical therapy (CI in preggos and young kids) |
|
Definition
|
|
Term
|
Definition
|
|
Term
recipe for empirical therapy |
|
Definition
1. macrolide, 2. Fluoroquinolone 3. beta lactam(if no allergy to penicillin) |
|
|
Term
broadspectrum abx G->G+ given PO with a B-lactamase inhibitor (clavulonic acid & sublactam) |
|
Definition
|
|
Term
prophylactic semisynthetic broad band peni |
|
Definition
ampicillin and amocxicillin |
|
|
Term
abx used to tx pseudomonas aeruginosa |
|
Definition
Carbenicillin and Ticarbicillin |
|
|
Term
Abx given with Cilastatin |
|
Definition
|
|
Term
abx used to tx serious G- infsn |
|
Definition
|
|
Term
this drug was last resort for severe G+ infxn and MOA: binds D-Ala-D-Ala |
|
Definition
|
|
Term
may cause redneck syndrom, be ototoxic or nephrotoxic |
|
Definition
|
|
Term
inhibit bacterial cell wall synthesis |
|
Definition
penicillins and cephalosporins (bacterioCIDAL) |
|
|
Term
pt with active TB should be tx'd with |
|
Definition
|
|
Term
topical ointment used to tx G+ inxn by affecting cell wall peptidoglycan syntehsis but is TOXIC |
|
Definition
|
|
Term
strongest activator of P450, TB drug. MOA is inhibiting DNA derived RNA polymerase |
|
Definition
|
|
Term
may cause red colored urine, feces, tears, sweat but is safe |
|
Definition
|
|
Term
1st line TB drug always given in COMBO tx that inhibits mycolic acid from binding proteoglycans |
|
Definition
|
|
Term
1st line TB drug that may cause green&red optic neuritis |
|
Definition
|
|
Term
|
Definition
REI- rifampin, ethambutol and isonazid |
|
|
Term
|
Definition
CASE: cycloserine, aminosalicyclic acid, squalamine, ethionamide |
|
|
Term
2nd line TB tx CI in pt with ulcers or G6P deficiency |
|
Definition
|
|
Term
Anti malaria drug that is prophylactic and targets the liver |
|
Definition
|
|
Term
prophylactic anti malaria drug with long duration. kills plasmodium in the RBC |
|
Definition
Chloroquine (CI in G6P-deh deficiency) |
|
|
Term
cheapest anti-malaria drug that is used in combo with sulfonamide and targets the RBC |
|
Definition
|
|
Term
anti malaria drug that ONLY AFFECTS RBC stage |
|
Definition
MAT: mefloquine, artemisinin (best) and tetrandrine |
|
|
Term
anti fungals target this in growing cells |
|
Definition
|
|
Term
|
Definition
garlic, oregano and lavender |
|
|
Term
best anti-fungal for a severe systemic fungal infxn. bacteriocidal. causes nephrotoxicity |
|
Definition
|
|
Term
Topical antifungal ampho-like. |
|
Definition
|
|
Term
anti-fungal that is synergistic with amphoB (a prodrug) used to tx sever fungal infxn |
|
Definition
|
|
Term
also an AntiCA drug, may cause BM depression, hair loss and liver abn |
|
Definition
|
|
Term
Topical drug, Antagonistic with AmphoB and inhibits fungal P450 |
|
Definition
|
|
Term
anti-fungal that crosses BBB, used to tx cryptoccal meningitis in AIDS pts |
|
Definition
|
|
Term
oral anti-fungal given for nail/hair infxn |
|
Definition
|
|
Term
drug used to treat PROPHYLACTIC influenza A and parkinson's Dz |
|
Definition
|
|
Term
may cause epilepsy and neuro probs (in an OD) |
|
Definition
|
|
Term
Amantadine analog used to tx Infuenza A and has less SE |
|
Definition
|
|
Term
drug used to tx hemorrhagic fever w/i 10 days of onset, herpes, Hep, HIV etc but may cause hemolytic anemia |
|
Definition
|
|
Term
Anti-viral given in HepB, Kaposi's sarcoma, NADPH oxidase def, to prevent Rhinovirus. May cause flu like sxs and neutropenia |
|
Definition
|
|
Term
AIDS tx prodrug that is synergistic with anti-virals |
|
Definition
|
|
Term
protease inhibitors what MUST be used in combo with protease inhibitors to prevent resistance. |
|
Definition
SIR: squinavir, indinavir, ritonavir |
|
|
Term
A combo of tetracyclin(s) + vancomycin(c) |
|
Definition
|
|
Term
A combo of amoxicillin and gentamycin |
|
Definition
|
|
Term
griseofulvin and ketoconazole |
|
Definition
|
|
Term
|
Definition
|
|
Term
flucytosine + amphotericin B cephalosporin + norfloxacin |
|
Definition
|
|
Term
28 yo M dxd with HIV- best drug combo |
|
Definition
AZT + 3 protease inh + acyclovir |
|
|
Term
21 yo F with non-drug resistant TB. what is teh best short term tx combo |
|
Definition
isoniazid+ rifampin + ethambutol |
|
|