Term
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Definition
| Interleukin that stimulates B cell to become plasma cell |
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Term
| Immunoglobulin(S) that can fix compliment |
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Definition
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Term
| Immunoglobulin(s) that are opsonins |
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Definition
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|
Term
| Most abundant immunoglobulin in serum |
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Definition
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Term
| Immunoglobulin that crosses placenta |
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Definition
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Term
| White blood cell(s) which are targets for IgE mediated histamine release |
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Definition
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Term
| Type of allergic reaction a/w IgE |
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Definition
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Term
| Conditions that cause high IgE levels |
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Definition
| Atopy and parasitic infections |
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Term
| Compliment components that are anaphylotoxins |
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Definition
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Term
| Compliment components that make up membrane attack complex |
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Definition
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Term
MHC I
# function
# found on what cells
# number of chains |
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Definition
# activates CD8 cells, target for cytotoxic T cells
# found on all nucleated cells
# single chain |
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Term
MHC II
# function
# found on what cells
# number of chains |
|
Definition
# activates CD4 cells, helper T cells, stimulates Ab formation
# on all APCs (B cells, dendrites, monocytes
# 2 chains |
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Term
| Functions of natural killer cells |
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Definition
# Recognizes cells witout self MHC
# responsible immunosurvaillance against cancer |
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Term
| Importance of helper T cells |
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Definition
# secretes IL-4 (stimulates B cells)
# secretes IL-2 (causes maturation of T cells)
# involved in delayed-type hyper sensitivity (brings in inflammatory cells by chemokine secretion) |
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Term
| Compliment cascade activated by Ab |
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Definition
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Term
| Compliment cascade activated by bacteria |
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Definition
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Term
| Point of convergence of classic and alternate compliment pathways |
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Definition
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Term
| Type I hypersensitivity rxn |
|
Definition
# Immediate hypersensitivity
# Bee stings, peanuts and hay fever |
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Term
| Pathophys of type I hyper sensitivity rxn |
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Definition
| IgE bind Ag, basophils bind the Ab-Ag complex and release major basic protein which causes mast cells and basophils release histamine, serotonin and brydikinin |
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Term
| Type II hypersensitivity rxn |
|
Definition
# IgG and IgM react with cell bound Ag
# ABO incompatibility, Rh incompatibility, Graves disease, Myasthenia, ITP |
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Term
| Type III hypersensitivity rxn |
|
Definition
# Immune complex deposition
# serum sickness, RA, SLE |
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Term
| Type IV hypersensitivity rxn |
|
Definition
# delayed-type hypersensitivity (Ag stimulation of previously sensitized T cells)
# Tb skin test contact dermititis |
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Term
|
Definition
| Converts KN cell to lymphokine activated killer |
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Term
| Best test to evaluate cell-mediated immunity |
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Definition
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Term
| Source of histamine in blood |
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Definition
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|
Term
| Source of histamine in tissue |
|
Definition
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Term
| Name of toxin and type responsible for gram negative sepsis |
|
Definition
| Lipopolysaccharide A is an endotoxin |
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Term
|
Definition
| > 77 % (normal is 66-77%) |
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Term
| SvO2 of cyanide poisoning |
|
Definition
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Term
|
Definition
| decreased Cardiac output or decreased SaO2 |
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|
Term
| 4 likeliest places for an intraabdominal abscess |
|
Definition
1. sub-diaphragmatic
2. sub-hepatic
3. interloop
4. pelvic |
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Term
|
Definition
| Oral vanco or IV/PO flagyl |
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|
Term
| Bacteria that cause infections that present within hours post-op |
|
Definition
| Beta-hemolytic strep or clostridial infections |
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Term
| Coagulas status of staph aureus |
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Definition
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|
Term
Aminoglycides
# cidal or static
# MOA
# mechanism of resistance |
|
Definition
# bacteriocidal
# irreversibly bind to ribosome
# resistance due to decreased active transport |
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|
Term
Tetracyclines
# cidal or static
# MOA |
|
Definition
# bacteriostatic
# reversibly binds to 30S ribosomal subunit |
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|
Term
Clindamycin
# cidal or static
# MOA |
|
Definition
# bacteriostatic
# reversibly binds to the 50S ribosomal subunit |
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|
Term
Vancomycin
# MOA
# mechanism of resistance |
|
Definition
# binds to plasma membran
# altered to cell wall structure |
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Term
| Mechanism of resistance of MRSA |
|
Definition
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|
Term
Amphotericin
# MOA
# adverse reactions |
|
Definition
# binds sterols to alter fungal cell wall
# renal impairment (80%), anemia, fever |
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Term
|
Definition
# inhibits DNA gyrase
** PO and IV routes bioequivalent |
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