Term
| Intrinsic pathway and way to measure |
|
Definition
Exposed collagen + XII -> activates XI -> activates IX + VIII -> activates X + V -> activates thrombin (II) -> cleaves fibrin to fibrinogen
# PTT |
|
|
Term
|
Definition
# Tissue factor + VII -> activates X + V -> activates thrombin -> activates fibrin
# PT |
|
|
Term
| Best single test to evluate synthetic function of liver |
|
Definition
|
|
Term
| Effect of storing blood on Hb dissociation curve and why |
|
Definition
| Causes left shift because decreased amount of 2,3-DPG which increasesHb affinity for O2 |
|
|
Term
| Contents of cryo and reasons to use it |
|
Definition
# Fibrinogen, vWF-VIII
# Von Willebrand disease, hemophilia A and DIC |
|
|
Term
| Mechanism of action of proteins C and S |
|
Definition
Protein C degrades factors V and VIII
Protein S helps protein C |
|
|
Term
| Only factor not made in the liver and where it's made |
|
Definition
| factor VIII (made in reticuloendothelial system) |
|
|
Term
| Factor with shortest half-life |
|
Definition
|
|
Term
| Labile factors whose activity is lost in stored blood |
|
Definition
|
|
Term
| Lab values affected by vWD |
|
Definition
| Long PTT, long bleeding time, +ristocetin assay |
|
|
Term
|
Definition
# Types I and III quantitatively low vWD
# type II had qualitatively poor vWF |
|
|
Term
|
Definition
# types I and III respond to DDAVP, as well as recombinant VIII:vWF, cryo, conjugated estrogens
# type II does not respond to DDAVP; tx is recombinant VIII:vWF and cryo |
|
|
Term
| Mechanisms of inheritance for different types of vWD |
|
Definition
# Types I and II are auto dominant
# Type III is auto-recessive |
|
|
Term
| MC congenital bleeding d/o |
|
Definition
|
|
Term
| Pathophys in Glanzmann's Thrombocytopenia |
|
Definition
| defect in platelet IIb/IIIa receptor causing poor platelet aggregation |
|
|
Term
| Only inherited coagulopathy with prolonged bleeding time |
|
Definition
|
|
Term
| Pathophys in Bernard Soulier |
|
Definition
| Ib deficiency which causes poor adherenec to exposed collagen |
|
|
Term
| Factor that crosses the placenta and clinical significance |
|
Definition
| VIII; since Hemophilia A is x-linked recessive, there may be a delay in diagnosis because a male pt wouldn't have excessive bleeding at circumcision since he has mom's factor VIII |
|
|
Term
| Mechanism of inheritance of Hemophilia A |
|
Definition
|
|
Term
| Pre-op management of hemophilia A |
|
Definition
|
|
Term
| Pre-op management of hemophilia B |
|
Definition
|
|
Term
| Mechanism of inheritance of Hemophilia B |
|
Definition
|
|
Term
| Management of hemophiliac joint |
|
Definition
# do not aspirate
# ice
# ROM therapy
# Give factor VIII |
|
|
Term
Lupus anticoagulant
# pathogenesis
# associated lab values
# Tx |
|
Definition
# caused by anti-phospholipid Ab (not necessarily a/w SLE) which is a hypercoagulable state
# positive Russel viper venom time, prolonged PTT which does not correct by adding normal plasma |
|
|
Term
Factor XII
# alternate name
# when it is comes into play and how it is handled |
|
Definition
# Hagemann factor
# activated by cardiopulmonary bypass which is why you need heparin |
|
|
Term
| Pathophysiology of Factor V Leyden |
|
Definition
| # factor V is mutated to make it resistant to activated protein C |
|
|
Term
| Action of plasmin and it's naturally occuring inhibitor |
|
Definition
| Degrades fibrinogen and is inhibited by alpha-2-plasmin inhibitor |
|
|
Term
# Mechanism of action of heparin
# associated lab values
# antidote |
|
Definition
Binds to ATIII which causes it to inactivate 9-12
# causes prolonged PTT
# protamine |
|
|
Term
| MOA of E-aminocaproic acid, primary uses |
|
Definition
# antifibrinolytic (inhibits clot breakdown- promotes clot formation) by inhibiting plasmin
# used in DIC, bleeding after cardiopulm bypass or orderdose of thrombolytics |
|
|
Term
|
Definition
# low plts
# low fibrinogen
# prolonged PTT
# high FDPs |
|
|
Term
| Source of prostacyclin and function |
|
Definition
# endothelium
# decreased platelet aggregation, vasodilation, bronchial relaxation |
|
|
