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Absite Killer gut physiology
GI hormones section of absite killer
26
Medical
Professional
01/19/2014

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Term
Vagus branches that give
# hepatic
# celiac
Definition
# Left
# Right
Term
Importance of Criminal nerve of Grassi
Definition
Branch of R vagus which, if left undivided, can cause persistantly high acid levels post vagotomy
Term
Cells that secrete pepsinogen and function
Definition
Chief cells; converted to pepsin and initiates proteolysis
Term
Cells responsible for acid secretion in stomach and 3 main stimulators for acid secretion
Definition
# parietal cells
# Gastrin, Histamine, Ach
Term
Cells that secrete gastrin and location
Definition
G cells in the antrum
Term
Gastrin stimulators and inhibitors
Definition
# Stimulated by amino acids and Ach
# inhibitied by H+ in the duodenum
Term
Cells responsible for intrinsic factor secretion
Definition
Parietal cells
Term
Mechanism of action of Ach and gastrin on parietal cells to produce H+
Definition
# active DAG and PIP which increase intracytoplasmic Ca which activates protein kinase C which increases HCl production
Term
Stimulus for SST secretion
Definition
H+ in the duodenum
Term
Effects of SST
Definition
# inhibits gastrin, insulin, secretin and Ach
# decreases biliary and pancreatic output
Term
Effect of truncal vagotomy on digestion
Definition
# abolishes receptive relaxation
# increases liquid emptying
# only increases solids emptying when performed with an pyloryplasty
# decreases basal acid secretion
Term
MC sx post-vagotomy
Definition
Diarrhea
Term
Causes of dumping syndrome and management
Definition
# early: high osmotic load causing a fluid shift
# late: increased insulin outpoint with decrease glucose
# most dumping responds to dietary measures
Term
Effects of CCK
Definition
# increase GB constraction
# relax sphincter of Oddi
# increase pancreatic enzyme secretion
Term
Where is CCK secreted
Definition
I cells in the duodenum
Term
function of secretin and where it is secreted
Definition
# increase pancreatic bicarb secretion
# secreted by S cells of the duodenum
Term
Cells that secrete SST and location
Definition
# D cells in the antrum
Term
Source of enterglucagon and function
Definition
# secreted from hypertrophied small bowel
# adaptation after bowel resection
Term
Source, stimulus and function of peptide YY
Definition
# released from terminal ileum in response to mixed meal
# inhibits acid secretion
# ileal break
Term
Composition of bile and ways that stones form
Definition
# 80% bile salts, 15% lecithin, 5% cholesterol
# stones form when chol concentration goes up or bile salts or lecithin goes down
Term
Way GB concentrates bile
Definition
# actively absorbes NaCl, H2O follows
Term
Enterohepatic circulation
Definition
# 5g of bile circulates q4h
# lose 0.5g daily
Term
Primary bile acids
Definition
# cholic acid
# chenodeoxycholic acid
Term
Secondary bile acids
Definition
# deoxycholic
# lithocholic acid
Term
Length, stages and regulator of interdigestive motility
Definition
# 90-min cycles (from stomach to TI)
# phase I: quiescence
# phase II: GB contraction
# phase III peristalsis
# subsiding electric activity
# motilin regulates
Term
Location and method of NaCl absorption in gut
Definition
jejunum; paracellular
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