Term
| b/w epinephrine and NE, one that's the most modified |
|
Definition
|
|
Term
| Enzyme that converts NE to Epi and exclusivity of it |
|
Definition
| PNMT and it's found only in the adrenal medulla |
|
|
Term
| MC extra-adrenal location of Pheo's |
|
Definition
| Organ of Zuckerkandle (Ao bifurcation) |
|
|
Term
|
Definition
# 10% rule:
* malignant
* bilateral
* in children
* part of MEN
* extra-adrenal |
|
|
Term
|
Definition
| urine metanephrines and VMA |
|
|
Term
| Test used to localize pheos |
|
Definition
|
|
Term
|
Definition
# s/p adrnalectomy, 10% experience increase ACTH production that causes:
* pigmentation
* vision changes |
|
|
Term
|
Definition
| Adrenal hemorrhage a/w meningococcal sepsis |
|
|
Term
| Breakdown of causal lesions in Conn's syndrome |
|
Definition
| 80% adenoma and 20% B/L hyperplasia |
|
|
Term
| Signs and symptoms of Conn's syndrome |
|
Definition
|
|
Term
| Lab abnormalities a/w Addison's disease |
|
Definition
| Low Na, high K, hypoglycemia |
|
|
Term
| Presentation of Addisonian crisis |
|
Definition
# looks like sepsis:
* hypotension
* fever
* hypoglycemia
* improve with glucocorticoids (diagnostic and therapeutic) |
|
|
Term
| MCC of congenital adrenal hyperplasia |
|
Definition
| 21-hydroxylase deficiency |
|
|
Term
| MCC of Cushing's syndrome |
|
Definition
|
|
Term
|
Definition
| high ACTH; can be suppressed on high dose dexamethasone suppression |
|
|
Term
| Dx if hypercortisolism and no suppression with dexamethasone suppression test |
|
Definition
| Adrenal Cushing's (syndrome) or Ectopic ACTH (like small cell lung CA) |
|
|
Term
| MC location of extopic ACTH production |
|
Definition
|
|
Term
| Function of posterior pituitary |
|
Definition
| secretes ADH and Oxytocin (produced in the paraventricular nuclei) |
|
|
Term
| Hormones secreted by anterior pituitary |
|
Definition
# GH
# ACTH
# TSH
# LH
# FSH
# Prolactin |
|
|
Term
| MC pituitary adenoma, symptoms and tx |
|
Definition
# prolactinoma
# produces galactorrhea, irregular menses
# medical: bromocriptine
# surgical: transphenoidal surgery |
|
|
Term
| Post-partum lack of lactation and persistant amenorrhea |
|
Definition
| Sheehan syndrom- caused by hemorrhage of anterior pituitary |
|
|
