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Abnormal WBC Characteristics
68K 12-01 Hemo 101 Unit 2
11
Other
Undergraduate 2
01/12/2012

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Term
Toxic Granulation
Definition
Larger than normal basophilic granules within cytoplasm, resemble primary granules, seen with acute bacterial, infections poisoning and burns.
Term
Dohle Bodies
Definition
Round, oval light blue staining area found in the cytoplasm, remnants of RNA, seen with toxic granulation in infections and burns.
Term
Auer Rods
Definition
Slender, rod shaped bodies within the cytoplasm. Compsoed of lysosomlal material and fused primary granules, seen in pts with acute myeloblastic leukemia.
Term
Pelger-Huet Cells
Definition
Observed with the nucleus fails to segent or form 3-5 lobes within the neutrophil, segments appear to be bilobed, inherited or acquired. Pelger-Huet Anomaly.
Term
Chediak-Higashi Cells
Definition
LArge granules seen in the cytoplasm of neutrophils, lymphocytes or monocytes, rare inherited syndrome treated with marrow transplant, disease state called chediak-Higashi syndrome.
Term
Alder Reilly Cells
Definition
heavy dark granulation in granulocytic cells, inherited condition Alder Reilly anomaly
Term
May Hegglin Inclusions
Definition
similar to dohle bodies but larger with sharper defined borders,, Plts are decreased but no other significant clinical sumptoms, MAy-Hegglin anomoly
Term
Malignant Lymphocytes
Definition
Clonal, all abnormal cells and appear very similar to one another.
Term
REactive Lymphocytes (atypical)
Definition
variable within single specimen, large and small cells, basophilic and pale cells, common to see darkly staining cytoplasm where it touches RBCs, often seen in Mono.
Term
Plasma Cell
Definition
Antigenically stimulated mature B lymphocyte, underglo blast transformation, will look the same (look for the perinuclear halo) function is to produce Ig.
Term
Smudge Cell
Definition
Damaged fragile wBCs with a frayed nuclei and no cytoplasm, cellsa re not counted within diff unless all/most look like smudge cells, only signif. when in large numbers, CLL
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