Term
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Definition
contact points between plasma membranes of tissue cells; some are pores
functions:
-forms seals between cells
-anchor cells to one another or extracellular material
-provide channels for materials to pass from cell to cell |
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Term
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Definition
web-like strands of protein that fuse outer surfaces of adjacent plasma membranes together; found in epithelial layer of stomach, intestines, and urinary bladder (kinda like a zipper) |
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Definition
contain plaque, dense layer of proteins on inside of plasma membrane; attaches to cytoskeleton proteins and membrane proteins; help epithelial cells resist separation |
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Term
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Definition
contain plaque and have transmembrane glycoproteins extending into intercellular space between adjacent cell membranes; intermediate filaments extend from one cell to another; found in epidermis and cardiac muscle |
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Term
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Definition
like desmosomes but lack links to adjacent cells; half desmosome; glycoproteins are integrins; anchor cells to basement membrane; found in epithelial tissue |
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Term
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Definition
membrane proteins called connexins form tiny fluid-filled tunnels called connexons that connect neighboring cells; plasma membranes separated by gap; enable nerve and muscle information to travel more quickly |
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Term
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Definition
location: covers and lines various parts of the body
functions: specializes in absorptions, secretion, and providing protective barriers |
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Definition
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Term
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Definition
more than one layer of cells |
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Term
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Definition
appears stratified but consists of only one layer of cells, some of which do not extend to the surface of tissue; found in treachea |
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Definition
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Definition
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Definition
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Term
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Definition
surface cells vary from sqamous to cuboidal depending on degree of stretching |
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Definition
usually arranged to form continuous sheets with very little intercellular material; sheets composed surface layer of skin and of mucous and serous membranes; basement membrane, an adhesive, permeable material, attaches epithelial layer to underlying layer of connective tissue |
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Definition
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Term
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Definition
no blood vessels in epithelial tissue; oxygen and food diffuse form capillaries in connective tissue beneath epithelium; plasma membranes of adjacent epithelial cells modified at interval so as to hold cells together; undergo division
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Definition
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Term
Simple Squamous Epithelium |
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Definition
single layer of flat cells
location: alveoli of lungs, lining of blood vessels, surface layer of serous membranes (pleura, pericardium, and peritoneum), capilaries, and kidneys
function: diffusion and filtration |
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Term
Stratified Squamous Epithelium |
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Definition
several layers of flat cells
location: forms surfaces exposed to wear and tear such as surface of skin and of mucous membrane lining the mouth, esophagus, and vagina
function: protection |
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Term
Simple Columnar Epithelium |
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Definition
single layer of columnar and goblet-shaped cells, and in some places. ciliated cells
location: composes surface of mucosa lining stomach, intestine, uterus, uterine tubes, and parts of respiratory tract
functions: absorption, secretion, and transport of mucus (stuff will move through it) |
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Term
Simple Cuboidal Epithelium |
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Definition
single layer of square-shaped cells
location: covers surface of ovaries, found in the eye, lines kidney tubules and smaller ducts of many glands
functions: secretion and absorption |
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Term
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Definition
location: composes secreting cells of endocrine (ductless) and exocrine (duct) glands
types: tubular, branched tubular, coiled, acinar, and branched acinar |
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Definition
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Term
Branched Tubular (simple) |
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Definition
gastric and uterine glands |
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Definition
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Definition
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Definition
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Term
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Definition
bulbourethral glands, testes, liver |
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Term
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Definition
sublingual, submandibular, and salivary glands |
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Term
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Definition
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Term
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Definition
accumulate product in cytoplasm and then die; contents discharged as glandular secretion (new cells replaces it)
[ex: sebaceous glands] |
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Term
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Definition
form and release secretory product; cells stay and are not affected [ex: salivary glands and pancreas] |
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Term
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Definition
accumulates product at outer margin of cell and pinches off that portion from the rest of the cell to form secretion [ex: mammary glands] |
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Term
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Definition
intercellular material (matrix) predominates and determines physical characteristics; consists of fluid, gel, or solid matrix, with or without fibers
function: connects, supports, transports, and defends
types: collagen, elastic, and reticular |
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Term
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Definition
very strong and resist pulling forces; promote tissue flexibility; consist of protein collagen; most abundant protein in body |
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Term
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Definition
smaller in diameter, branch, and join together to form network within a tissue; consist of protein elastin surrounded by glycoprotein fibrillin; strong but can be stretched 150% of their relaxed length; exhibit elasticity |
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Term
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Definition
consist of collagen arranged in fine bundles and a coating of glycoprotein; provide support in walls of blood vessels and form network around cells in some tissues; much thinner than collagen fibers; form branching networks; provide support and strength |
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Term
Loose, Ordinary Connective Tissue (Areolar) |
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Definition
intercellular substance is prominent and consists of collagenous and elastic fibers loosely interwoven and embedded in soft viscous ground substance; has reticular fibers (contain all three types of fibers) |
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Term
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Definition
several kinds of cells present - fibroblasts (form collagenous fibers if tissue injured), macrophages (defense), mast cells (form histamine), adipose cells, plasma cells (formed from lymphocytes), and some white blood cells
function: strength, elasticity, and support (forms subcutaneous layer of skin) |
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Term
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Definition
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Term
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Definition
similar to loose but contains mainly adipocytes (fat cells); cannot see fibers
locations: subcutaneous layer of skin, around heart and kidneys, marrow of long bones, and padding around joints
functions: protection, insulation, support, and reserve food |
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Term
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Definition
consists of network of branching reticular fibers (thin, branch, support, and strength) with reticular cells overlying them
locations: forms framework of spleen, lymph nodes, liver, and bone marrow
functions: defense against microbes and other injurious substances; reticular meshwork filters out injurious particles and reticular cells phagocytose them |
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Term
Dense Fibrous (Collagenous) Tissue |
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Definition
matrix consists mainly of bundle of collagenous fibers and relatively few fibroblast cells
locations: composes structures that need great tensile strength, such as tendons and ligaments
functions: furnishes flexible but strong connection |
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Term
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Definition
consists of dense network of collagenous fibers and elastic fibers embedded in jellylike substance; cells are chondrocytes and occur singly or in groups within spaces called lacunae
types: hyaline, fibrocartilage, and elastic cartilage |
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Term
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Definition
collagenous fibers not visible; chondrocytes found in lacunae are very prominent; most abundant cartilage in body; found at ribs, joints at end of long bones, nose, larynx, trachea, and bronchi |
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Term
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Definition
chondrocytes scattered through bundles of collagenous fibers; found at pubic symphysis, menisci of the knee, and intervertebral discs |
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Term
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Definition
chondrocytes located in threadlike network of elastic fibers; provides stregth and shape; located in ear, larynx, and auditory tube |
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Term
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Definition
combination of an epithelial layer and underlying connective tissue layer |
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Term
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Definition
lines body cavity opening directly to exterior; lines GI, respiratory, excretory, and reproductive tracts |
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Term
Serous Membranes (Serosa) |
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Definition
lines a body cavity that does not open to the exterior and covers the organs that lie within the cavity; consists of parietal (lines cavity) and visceral portion (covers organs); includes pleural, pericardial, and peritoneal membranes |
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Term
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Definition
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Term
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Definition
lines cavities of freely movable joints; composed of loose connective tissue with elastic fibers and varying amounts of fat; secrete synovial fluid |
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Term
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Definition
functions: provides motion, maintains posture, and generates heat |
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Term
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Definition
striated, voluntary - multinucleated; attaches to bone |
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Term
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Definition
striated, involuntary - branched, intercalated discs; heart |
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Term
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Definition
visceral, involuntary - spindle-shaped cells; lines internal organs |
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Term
Regeneration or Resolution |
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Definition
restorstion of original structural and physiological function |
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Term
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Definition
replacement of destroyed tissue with scar tissue - fibroblasts synthesize collagen and other materials that form scar tissue; function of tissue impaired |
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Term
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Definition
essential for epithelial tissue |
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Term
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Definition
needed for enzyme systems |
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Term
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Definition
affects collagen synthesis and formation of new blood vessels |
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Term
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Definition
healing of bone fractures; increased calcium absorption |
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Term
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Definition
may prevent scarring; promote healing |
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Term
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Definition
needed for blood clotting |
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Term
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Definition
consists of the skin, hair, nails, ect. |
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Term
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Definition
outer layer of skin, stratified squamous epithelium
layers: stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale |
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Term
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Definition
outermost layer of the epidermis, dead, keratinized cells |
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Term
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Definition
clear, flat, dead cells with eleidin; only in palms, soles, and fingertips |
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Term
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Definition
3-5 rows containing granules of keratohyalin (1st step in keratin formation) |
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Term
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Definition
8-10 rows of epidermis in between stratum granulosum and stratum basale |
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Term
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Definition
innermost layer of epidermis; hairless skin contains Merkel's (tactile) disc, Langerhans cells, and melanocytes |
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Term
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Definition
the most numerous of the epidermal cells; produce keratin |
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Term
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Definition
saucer-shaped free nerve endings that make contact with Merkel cells in the epidermis and function as touch receptors |
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Term
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Definition
epidermal dendritic cells that function as an antigen-presenting cell (APC) during an immune response |
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Term
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Definition
a pigmented cell, located between or beneath cells of the deepest layer of the epidermis, that synthesis melanin |
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Term
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Definition
second layer of the skin; consists of the papillary layer and the reticular layer |
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Term
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Definition
found in dermis; next to basement membrane; papillae arranged to form ridges (dermal papillae); meissner's corpuscles (corpuscles of touch) may be present; basis for fingerprinting |
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Term
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Definition
dense, irregular connective tissue containing collagenous and elastic fibers; with adipose tissue, hair follicles, nerves, sebaceous glands, and ducts of sudoriferous glands |
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Term
Superficial Fascia (Hypodermis) |
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Definition
layer of areolar and adipose tissue under dermis; contains Pacinian (lamellated) corpuscles which are sensitive to pressure; storage depot for fat and contains largge blood vessels that supply the skin |
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Term
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Definition
due to melanin found in stratum basale and spinosum; also carotene (in dermis) and blood in capillaries in dermis |
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Term
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Definition
dependent on heredity, exposure to sun, and hormones (MSH and ACTH) |
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Term
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Definition
protection: prevents invasion of dermis and deeper structures by microorganisms, chemicals, and radiation rays/temperature regulation: related to varying amounts of blood in dermis and amount of sweat secreted/ sensation: sensations of heat, cold, pressure, and pain/ vitamin D synthesis: steroid compound in skin converted to vitamin D in presence of sunlight/ (can be reservoir for blood) & (excretion & absorption) |
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Term
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Definition
over entire body except palms of hands and soles of feet and few other small areas
functions: protection, sensing light touch, and decreases heat loss at scalp |
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Term
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Definition
forms innermost layer of follicle and germinal matrix; germinal matrix forms hair |
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Term
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Definition
cluster of capillaries under matrix |
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Term
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Definition
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Term
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Definition
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Term
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Definition
surrounds root of the hair |
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Term
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Definition
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Term
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Definition
about 5 inches per year; has growth and resting stages |
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Term
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Definition
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Term
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Definition
attach to follicle; secrete sebum, an oily substance, into follicle |
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Term
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Definition
attach to follicle; contractions produces "goose bumps" |
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Term
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Definition
consist of epidermal cells converted to hard keratin |
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Term
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Definition
mitosis of cells in stratum basale beneath lunula; about 1 inch per year |
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Term
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Definition
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Term
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Definition
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Term
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Definition
moon-shaped white area nearesy root |
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Term
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Definition
epithelium under nail body; contains blood vessels |
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Term
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Definition
secrete sebum-lubricates hair and skin; secretion increases during adolescence and decreased as one gets older |
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Term
Sudoriferous (Sweat) Glands |
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Definition
numerous in most areas of skin - especially palms, soles, forehead, and axillae; involved in maintaining homeostasis of body temperature |
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Term
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Definition
excretory ducts opens into hair follicles |
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Term
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Definition
located in external ear canal; secrete cerumen (ear wax) - provides sticky barrier preventing entrance of foreign bodies |
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Term
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Definition
types: abrasion, 1st or 2nd degree burn; basal cells move into area of wound and enlarge (migration stops by contact inhibition); migration continues until wound is resurfaced; cells form new strata; epidermal growth factor (hormone found at wounds to stimulate growth of epidermal cells and fibroblasts) |
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Term
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Definition
hormone found at wound to stimulate growth of epidemal cells and fibroblasts |
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Term
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Definition
injury well below epidermis; consist of four phases: inflammatory, migratory, proliferative, and materation; some will form scars |
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Term
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Definition
vascular and cellular response resulting in blood clot and white bloos cells migration to destroy invading microorganisms |
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Term
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Definition
scab forms; epidermal cells migrate beneath scab to bridge wound; fibroblasts form scar tissue; granulation tissue formed |
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Term
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Definition
extensive growth of epidermal cells; deposition of collagen |
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Term
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Definition
scab sloughs off with replacement of epidermal cells to original thickness; collagen fibers organize (some of the collagen fibers will form scars) |
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Term
Ectoderm, Mesoderm, & Endoderm |
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Definition
three germ layer formed during gastrula stage |
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Term
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Definition
form in the 2nd-4th month of pregnancy |
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Term
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Definition
form in the 3rd month of pregnancy |
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Term
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Definition
formed in the 3rd-4th months of pregnancy |
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Term
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Definition
fetal hair; formed in 5th-6th months of pregnancy |
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Term
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Definition
connective tissue and blood vessels; dermis |
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Term
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Definition
excessive exposure to ultraviolet radiation from the sun or tanning beds
three types: basal cell carcinomas, squamous cell carcinomas, and malignant melanomas |
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Term
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Definition
account for about 78% of all skin cancer; tumors arise from cells in the stratum basale of the epidermis and rarely metastasize; known as nonmelanoma skin cancer |
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Term
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Definition
account for about 20% of skin cancer; arise from the stratum spinosum of the epidermis; have a varible tendency to metastasize; known as nonmelanoma skin cancer |
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Term
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Definition
account for about 2% of all skin cancer; arise form melanocytes |
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Term
Risk Factors for Skin Cancer |
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Definition
skin type, sun exposure, family history, age, and immunological status |
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Term
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Definition
tissue damage caused by excessive heat, electricity, radioactivity, or corrosive chemicals that denature (break down) proteins in the skin |
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Term
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Definition
involve only the epidermis; characterized by mild pain and erythema (redness) but no blisters; partial-thickness burns
[ex: mild sunburn] |
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Term
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Definition
destory the epidermis and part of the dermis; some skin functions are lost; redness, blister formation, edema, and pain result; partial-thickness burns |
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Term
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Definition
destory the epidermis, dermis, and subcutaneous (hypodermis) layer; most skin functions are lost; full-thickness burn |
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Term
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Definition
caused by a constant deficiency of blood flow to tissues; also known as decubitus ulcers or bedsores |
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Term
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Definition
functions:
-supportion framwork
-protection, movement-levers for muscle action
-mineral reservoir-calcium
-hemopoiesis (hematopoiesis)-blood cell formation by red marrow
-energy storage-lipids stored in yellow marrow |
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Term
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Definition
hollow, shaftlike portion of bone; compact bone |
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Term
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Definition
ends of long bone; spongy bone |
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Term
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Definition
region where diaphysis joins epiphysis; includes epiphyseal plate
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Term
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Definition
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Term
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Definition
dense white fibrous membrane covering bone except at joint surfaces; contains blood vessels and bone-forming cells (osteoblasts) |
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Term
Marrow (Medullary) Cavity |
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Definition
filled with yellow (fatty) marrow |
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Term
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Definition
lines marrow (medullary) cavity |
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Term
Short, Flat, and Irregular Bones |
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Definition
spongy (cancellous) bone forms inside and compact bone forms outside; red marrow in spaces of spingy bone inside few irregular and flat bones (vertebrae, sternum, and pelvic bones) |
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Term
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Definition
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Term
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Definition
unspecialized cells, develop into osteoblasts; found in periosteum, endosteum, perforating and central canals |
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Term
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Definition
develop into bone cells but lost ability to divide; secrete collagen and other aorganic components |
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Term
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Definition
mature bone cells; formed as matrix develops around osteoblasts |
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Term
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Definition
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Term
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Definition
organic matrix impregnated with calcium salts and reinforced with collagenous fibers |
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Term
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Definition
concentric layers of matrix |
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Term
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Definition
spaces containing osteocytes |
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Term
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Definition
connect lacunae and Haversian (central) canal; for fluid movement |
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Term
Haversian (Central) Canal |
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Definition
contains blood and lymphatic vessels |
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Term
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Definition
weblike arrangement of marrow-filled spaces; separated by thin processes of bone called trabeculae |
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Term
Intramembranous Ossification |
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Definition
occurs in flat bones of roof of skull, parts of mandibles, and clavicles; osteoprogenitor cells converted to osteoblasts within fibrous membrane at center of ossification; osteoblasts secrete intercellular substances; form matrix of calcim salts (calcification); calcification leads to formation of spongy bone and eventually compact bone |
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Term
Endochondral Ossification |
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Definition
mesenchyme cells converted to chondroblasts; covered by perichondrium; cells in midregion hypertrophy; burst, changing pH of matrix & trigger calcification; leads to death of cartilage cells & empty lacunae; nutrient artery penetrates perichondrium stimulation osteoprogenitor cells begin to enlarge & becone osteoblasts; growth begins in middle of diaphysis & spreads to epiphysis |
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Term
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Definition
cartilage model grows in length by cell division of chondroblasts |
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Term
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Definition
growth in thickness comes by division of chondroblasts in perichondrium |
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Term
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Definition
occurs by continual thickening of epiphyseal cartilage followed by ossification |
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Term
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Definition
medullary cavity enlarged by osteoclasts destroying bone around it while new bone added around circumference by osteoblasts |
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Term
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Definition
consists of four zones: zone of resting cartilage, zone of proliferating cartilage, zone of hypertrophic (maturing) cartilage, and zone of calcified cartilage |
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Term
Zone of Resting Cartilage |
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Definition
near epiphysis; small, scattered chondrocytes; anchor epiphyseal plate to bone of epiphysis |
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Term
Zone of Proliferating Cartilage |
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Definition
larger chondrocytes stacked like coins; divide to replace those at diaphyseal surface of epiphyseal plate |
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Term
Zone of Hypertrophic (Maturing) Cartilage |
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Definition
larger chondrocytes arranged in columns; results in lengthwise expansion as cells mature |
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Term
Zone of Calcified Cartilage |
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Definition
few cells thick; lay bone on calcified cartilage cementing diaphyseal borders to diaphysis |
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Term
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Definition
region between diaphysis and epiphysis; can only grow by appositional growth; allows growth in length until early adulthood under control of GH (growth hormone); |
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Term
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Definition
formed when epiphyseal cartilage cells stop dividing and is replaced by bone |
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Term
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Definition
ongoing replacement of old bone tissue by new bone tissue
-formation exceeds resorption during growth years (infancey through adolescence)
-formation and resorption balance during young adulthood
- later (35-40) more bone resorbed at endosteal surface than formed at periosteal surface; net loss weakens bones; fracture easier |
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Term
Vitamins and Minerals Needed for Remodeling |
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Definition
calcium, phosphorus, magnesium, boron, manganese, vitamin D, vitamin C, vitamin A, and vitamin B12 |
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Term
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Definition
setting fracture without surgery |
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Term
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Definition
setting fracture with surgery |
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Term
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Definition
1) fracture hematoma-6 to 8 hrs. after injury
2) procallus-infiltration of capillaries and organization to granulation tissue
3) fibrocartilaginous (soft) callus-fibroblasts produce collagen and chondroblasts produce fibrocartilage (3 wks.)
4) bony (hard) callus-osteogenic cells→osteoblasts→ trabeculae (3-4 months)
5) remodeling of callus-dead portions resorbed by osteoclasts; compact replaced spongy |
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Term
Parathyroid Hormone & Calcitonin |
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Definition
the action through which the bone is involved in calcium homeostasis |
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Term
Developmental Anatomy of Bone |
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Definition
-notochord formed form mesoderm; surrounded by other mesodermal tissue forming vertebral column; only remnant of notochord is nucleus palposus of intervertebral discs
-limb buds appear at 5 weeks consisting of mesodermal tissue covered by extoderm |
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Term
Developmental Anatomy of Skeletal System |
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Definition
-develop constriction by 6 weeks forming hand plates and foot plates; cartilaginous skeleton present
-by 8th week shoulder and hip area evident and endochondral ossification has begun |
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Term
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Definition
the broken ends of the bone protrude through the skin |
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Term
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Definition
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Term
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Definition
the bone is splintered, crushed, or broken into pieces at the site of impact, and smaller bone fragments lie between the two main fragments |
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Term
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Definition
a partial fracture in which one side of the bone is broken and the other side bends; similar to the way a green twig breaks on one side while the other side stays whole, but bends; occurs only in children, whose bones are not fully ossified and cantain more organic material than inorganic material |
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Term
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Definition
one end of the fractured bone is forcefully driven into the interior of the other |
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Term
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Definition
fracture of the distal end of the lateral leg bone (fibula), with serious injury of the distal tibial articulation |
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Term
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Definition
fracture of the distal end of the lateral forearm bone (radius) in which the distal fragment is displaced posteriorly |
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Term
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Definition
an area where skin has been scraped away |
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Term
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Definition
a collection of serous fluid within the epidermis or between the epidermis and dermis, due to short-term but severe friction |
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Term
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Definition
refers to a large blister |
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Term
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Definition
an area of hardened and thickened skin that is usually seen in palms and soles and is due to persistent pressure and friction |
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Term
Cold Sore (Fever Blister) |
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Definition
a lesion, usually in an oral mucous membrane, caused by Type 1 herpes simplex virus (HSV) transmitted by oral or respiratory routes; virus remains dormant until triggered by factors such as ultraviolet light, hormonal changes, and emotional stress |
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Term
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Definition
a collection of sebaceous material and dead cells in the hair follicle and excretory duct of the sebaceous (oil) gland; usually found over the face, chest, and back; more common during asolescence |
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Term
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Definition
inflammation of the skin characterized by redness, itching, and swelling and caused by exposure of the skin to chemicals that bring about an allergic reaction, such as poison ivy toxin |
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Term
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Definition
condition in which tissue deep to the skin is damaged, but the epidermis is not broken |
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Term
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Definition
a painful conical thickening of the stratum corneum of the epidermis found principally over toe joints and between the toes, often caused by friction or pressure; may be hard or soft, depending on their location; hard are found over toe joints while soft are usually found between the 4th and 5th toe |
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Term
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Definition
a sac with a distinct connective tissue wall, containing a fluid or other material |
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Term
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Definition
an inflammation of the skin characterized by patches of red, blistering, dry, extremely itchy skin; occurs mostly in skin creases in the wrists, backs of the knees, and fronts of the elbows; typically begins in infancy and many children outgrow the condition; cause is unknown but is linked to genetics and allergies |
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Term
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Definition
local destruction of skin and subcutaneous tissue on exposed surfaces as a result of extreme cold; in mild cases, the skin is blue and swollen and there is slight pain; in severe cases, there is considerable swelling, some bleeding, no pain, and blistering; if untreated, gangrene may develop; treated by rapid rewarming |
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Term
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Definition
localized benign tumor of the skin and subcutaneous layer that results from an abnormal increase in blood vessels; one type is a portwine stain, a flat, pink, red, or purple lesion present at birth, usually at the nape of the neck |
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Term
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Definition
reddened elevated patched of skin that are often itchy; nost commonly caused by infections, physical trauma, medications, emotional stress, food additives, and certain food allergies |
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Term
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Definition
an elevated, irregular darkened area of excess scar tissue caused by collagen formation during healing; it extends beyond the original injury and is tender and frequently painful; occurs in the dermis and underlying subcutaneous tissue, usually after trauma, surgery, a burn, or severe acne; more common in people of African descent |
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formation of a hardened growth of epidermis tissue, such as a permalignant lesion of the sun-exposed skin of the face and hands |
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an irregular tear of the skin |
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are tiny, jumping arthropods that suck blood from the scalp; they lay eggs, called nits, and their saliva causes itching that may lead to complications |
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are tiny arthropods that do not jump; they look like miniature crabs |
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a small, round skin elevation less than 1 cm in diameter [ex: a pimple] |
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itching, one of the most common dermatological disorders; may be caused by skin disorders (infections), systemic disorders (cancer, kidney failure), psychogenic factors (emotional stress), or allergic reactions |
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a common and chronic skin disorder in which keratinocytes divide and move more quickly than normal form the stratum basale to the stratum corneum; as a result, the surface cells never get a chance to cycle into the later keratinizing stages; the surface cells are shed immaturely on the scalp are called dandruff |
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Tinea Corporis (Ringworm) |
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a fungal infection characterized by scaling, itching, and sometimes painful lesions that may appear on any part of the body; called tinea cruris (jock itch) in the groin and tinea pedis (athlete's foot) in between the toes |
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in reference to a medication, applied to the skin surface rather than ingested or injected |
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mass produced by uncontrolled growth of epithelial skin cells; caused by a papillomavirus; most are noncancerous |
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a condition of porous bones; resorption (breakdown) outpaces deposition (formation) of the bone |
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two forms fo the same disease that result from inadequate calcification of the extracellular bone matrix; usually caused by a vitamin D definciency |
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the degeneration of articular cartilage such that the bony ends touch; the resulting friction of bone against bone worsens the condition; usually associated with the elderly |
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an infection of bone characterized by high fever, sweating, chills, pain, nausea, pus firmation, edema, and warmth over the affected bone and rigid overlying muscles; often caused by bacteria that may reach the bone form outside the body; form other sites of infection in the body via the blood; and from adjacent soft tissue infections |
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reduced bone mass due to a decrease in the rate of bone synthesis to a level too low to compensate for normal bone resorption; any decrease in bone mass below normal [ex: osteoporosis] |
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bone cancer that primarily affexts osteoblasts and occurs most often in teenagers during their growth spurt; the most common sites are the metaphyses of the thigh bone (femur), shin bone (tibia), and arm bone (humerus); metastases occur most often in of the malignant growth, or amputation of the limb |
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