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A&P Exam 3
Neural Pathways, Autonomic Nervous System, Muscles
98
Anatomy
Undergraduate 4
12/09/2013

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Term
special senses
Definition
taste, hearing, equilibrium, vision, smell
Term
general senses
Definition
pressure, touch, temperature, vibration, proprioception, pain
Term
dermatomes
Definition
incorporate multiple receptive fields, but all the receptor cells in one dermatome will ultimately follow into one spinal nerve
Term
nocioceptor
Definition
sensory receptor that detects pain
Term
thermoreceptor
Definition
sensory receptor that detects temperature
Term
mechanoreceptors
Definition
sensory receptor that detects physical distortion
Term
chemoreceptors
Definition
sensory receptor that detects chemical concentrations
Term
proprioreceptors
Definition
sensory receptor that detects position, purely somatic (not visceral)
Term
1ST order neuron
Definition
1st to receive sensory input, contains the sensory receptor
Term
2ND order neuron
Definition
interneuron, located in the spinal cord and/or brainstem, middleman
Term
3rd order neuron
Definition
travels from the opposite side (from the stimulus) of thalmus to cortex. If a neuron travels to the cortex, it reaches our awareness (perception), synapses on primary sensory cortex (post central gyrus)
Term
Decussation
Definition
the crossing of an axon (or entire tract) from the left side to the right side, or vice versa
Term
posterior columns pathway
Definition
senses fine touch, pressure, vibration, proprioception
Term
spinothalamic (anteriolateral) pathway
Definition
senses crude touch, pressure, pain, temperature. Anterior and lateral pathways are often combined.
Term
ipsilateral
Definition
same side
Term
contralateral
Definition
opposite side
Term
Phantom limb pain
Definition
neurons can be activated along the anterolateral pathway (inside the cord...the cord is still intact, the limb is missing) giving the perception of pain
Term
Referred pain
Definition
strong visceral pain sensations enter the spinal cord at a specific spinal segment, activating interneurons associated with the anterolateral pathway
Term
sensory humunculus
Definition
area of sensory cortex devoted to a particular body region, proportional to the number of sensory receptors, (NOT the size of the body region)
Term
Sensory Homunculus: face, jaw, and tongue
Definition
inferior and lateral portion of the primary sensory cortex
Term
Sensory Homunculus: feet
Definition
inferior, medial region
Term
Sensory Homunculus: torso
Definition
superior, medial region
Term
Sensory Homunculus: the hand
Definition
takes up a large portion of the sensory homunculus because we have many sensory receptors in our hand
Term
spinocerebellar pathway
Definition
senses position of skeletal muscles, tendons, joints
Term
+ Romberg's sign
Definition
damage to dorsal side, posterior columns of spinal cord, damage to dorsal medulla
Term
upper motor neuron
Definition
cell body is located in the brain or brainstem, it is the "originator" of conscious movement
Term
Lower motor neuron
Definition
cell body is located in the brain stem or spinal cord, it is the "final" neuron that will carry signals to the muscle to cause movement
Term
Corticobulbar neurons
Definition
neurons that travel from the cortex to the brainstem
Term
Corticospinal neurons
Definition
neurons that travel from the cortex to the spinal cord
Term
corticospinal pathway
Definition
carries signals for voluntary control over the skeletal muscles
Term
Motor Homunculus
Definition
area of primary motor cortex devoted to a particular body region, proportional to the number of motor neurons (NOT the size of the body region)
Term
Motor Homunculus: face and tongue
Definition
inferior, lateral region
Term
Atuonomic Nervous System
Definition
maintains homeostatic adjustments without conscious thought
Term
"brain dead"
Definition
ANS still working, but cortex is not
Term
Sympathetic nervous system
Definition
more active during "fight or flight"
Term
Parasympathetic nervous system
Definition
more active during rest and/or digestion
Term
Hypothalmus
Definition
the integrative center for autonomic activities. Neurons travel from the HT to the brainstem and spinal cord
Term
Preganglionic neurons
Definition
cell bodies live in the brainstem or spinal cord and travel to the ganglia, where they synapse
Term
Ganglia
Definition
a collection of cell bodies OUTSIDE the CNS
Term
Sympathetic nervous system ganglia
Definition
ganglia are located in chain ganglia very close to the vertebral column. The preganglionic neurons of the SNS are very short, since they only have to travel from the brainstem/ spinal cord to the chain
Term
Parasympatheitc nervous system ganglia
Definition
ganglia are located within or near the target organ (much further from the spinal cord). Preganglionic neurons of the PNS are long
Term
Postganglionic neurons
Definition
cell bodies live in the ganglia and the axons travel to the target organ
Term
SNS postganglionic neurons
Definition
long, have to travel from the chain near vertebra to the target organ
Term
PNS postganglionic neurons
Definition
short, ganglia are typically at or near the target organ
Term
Domination of the SNS results in
Definition
increased mental alertness, increased metabolic rate, mobilization of energy reserves, reduced digestion/ urination, increased respiratory rate/ dilation of passageways, increased heart rate and bp, sweat glands activated, elevation of muscle tone, dilated pupils, ejaculation
Term
Cholinergic
Definition
neurons that respond to Ach
Term
NE
Definition
stimulates primary alpha receptors
Term
Epi
Definition
stimulates alpha and beta receptors
Term
alpha-1 receptor
Definition
activation constricts blood vessels, increases bp
Term
beta-1 receptor
Definition
activation increases heart rate
Term
beta-2 receptor
Definition
activation dilates respiratory passages, relaxes smooth muscle
Term
beta-3 receptors
Definition
activation mobilizes adipose tissue via lypolysis (burning fat)
Term
G-protein
Definition
the membrane receptor is coupled to an enzyme complex. When the receptor is activated, the G-protein then increases or decreases enzyme production within the cell
Term
Preganglionic axons
Definition
leave the CNS from cranial nerves: occulomotor, facial, glossopharyngeal, and vagus. Vagus is most important, 75% travels through
Term
DOmination of the PNS results in
Definition
constriction of pupils, digestive secretions, liver secretions, blood flow changes associated with digestion and sexual arousal, increased smooth muscle activity to colon, intestines, coordinaiton of defecation, contraction of bladder for urination (micturition), constriciton of respiratory passages, decreases HR, sexual arousal (erection)
Term
ACh
Definition
acetylcholine, released by both the pre and post-ganglionic neurons in the PNS
Term
AChe
Definition
Acetylcholinesterase, degrades ACh very quickly, so ACh is short lasting
Term
nicotinic receptors
Definition
always excititory by Ach
Term
muscarinic resceptors
Definition
GZ-protein activated, excititory or inhibitory
Term
Autonomic tone
Definition
the levels of both PNS and SNS outflow make up autonomic tone
Term
"background level"
Definition
some PNS and some SNS. This allows for greater range to alter autonomic outflow
Term
multinucleate
Definition
multiple nuclei along the entire muscle fiber
Term
sarcolemma
Definition
cell membrane of a muscle fiber
Term
sarcoplasm
Definition
cytoplasm of a muscle fiber
Term
sarcoplasm reticulum
Definition
forms tubular complex around each myofibril, holds calcium for muscle contraction
Term
transverse tubules
Definition
narrow tubes that are continuous with the sacrolemma and extend into the sarcoplasm at right angles to the cell surface
Term
myofibrils
Definition
cylindrical structures that run the length of a muscle fiber (>100/cell), allow a muscle to contract
Term
thin filaments
Definition
composed mainly of actin
Term
thick filaments
Definition
composed mainly of myosin
Term
sarcomere
Definition
repeating units of myosin/actin (thin/thick filaments), smallest functional unit of muscle cell, ~10,000 sarcomeres per myofibril
Term
sliding filament theory
Definition
thin filaments slide toward thick filament and muscle contracts
Term
epimysium
Definition
entire muscle surrounded by this layer, separates muscle from surrounding tissue and organs
Term
perimysium
Definition
divides skeletal muscle into fascicles
Term
fascicles
Definition
a bundle of muscle fibers
Term
endomysium
Definition
surround individual muscle cells, or muscle fibers
Term
nerves
Definition
axons enter the endomysium to innervate muscle fibers
Term
motor unit
Definition
motorneuron and all the fibers it innervates
Term
fine control
Definition
(eye muscle) 4-6 muscle fibers innervated by one motor neuron
Term
gross control
Definition
(quadriceps) >1000 muscle fibers innervated by one motor neuron. When one motorneuron is stimulated, one big muscle contracts
Term
muscle spindles
Definition
stretch
Term
golgi tendon organs
Definition
tension
Term
overall functions of skeletal muscle
Definition
produce movement, maintain posture and body position, support soft tissues, guard entrances/exits, maintain body temperature, store nutrient reserves
Term
atrophy
Definition
loss of muscle mass
Term
cschexia
Definition
tissue wasting occurs within chronic disease, especially cancer, extreme muscle wasting
Term
sarcopenia
Definition
muscle atrophy that occurs with aging
Term
rhabdomyolosis
Definition
rapid skeletal muscle breakdown; can cause kidney damage, lead to renal failure. treatable if you know
Term
neuromuscular junction
Definition
intercellular connection between motorneuron or muscle fiber
Term
synaptic cleft
Definition
space between the motorneuron and the muscle fiber
Term
motor end plate
Definition
region on the sarcolemma of the muscle fiber that receives neurotransmitter
Term
excitation concentration coupling
Definition
link between generation of an action potential in the sarcolemma and the start of the muscle contraction
Term
rigor mortis
Definition
ATP no longer available after death to re-pivot myosin, stays contracted, Ca released into sarcoplasm and stays (bc ATP no longer available to pump Ca back into SR), causing continuous contraction
Term
twitch summation
Definition
repeating twitches, occurs when full relaxation does not occur
Term
incomplete tetanus
Definition
a muscle producing almost peak tension during rapid cycles of contraction and relaxation
Term
complete tension
Definition
occurs when a higher stimulation frequency eliminates the relaxation phase
Term
recruitment
Definition
smooth, steady increase in muscle tension produced by increasing the number of active motor units
Term
fast fibers
aka Type II-B
Definition
large diameter, densely packed myofibrils, few mitochondria, large glycogen reserves. Easily fatigued, white in color, glycolytic, sprinters
Term
slow fibers
aka Type I
Definition
smaller diameter, longer to reach peak tension, more capillaries. Slow to fatigue, red in color, oxidative, marathon
Term
intermediate fibers
aka Type II-A
Definition
fibers can switch to more slow or more fast, but typically do not completely transform from one type to another.
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