Term
| What immunoglobulin classes are capable of fixing complement? |
|
Definition
|
|
Term
| How does normal circulating IgG not persistently activate complement? |
|
Definition
| Classical pathway is only activated by antibodies bound to antigen |
|
|
Term
| Steps in activation of alternative complement pathway |
|
Definition
* C3 undergoes spontaneous cleavage to C3b
* C3b coats bacterial surfaces
* Protein B binds C3b, forming C3bB complex
* Protein D cleaves C3bB complex, forming C3bBb
* C3bBb can cleave C3 to form C3b in a positive feedback loop
* C3b activates complement effectors |
|
|
Term
| How is the mannose-binding lectin complement pathway activated? |
|
Definition
* MBL, which resembles C1 component, binds bacterial sugars
* MBL triggers C4 and C2 activation
* C3 is cleaved to C3b, which activates complement effectors |
|
|
Term
| Components of the complement system that are species-specific |
|
Definition
|
|
Term
| Are complement deficiencies normally related to consumption or production issues? |
|
Definition
| Consumption (eg, immune complexes, opsonization, etc.) |
|
|
Term
| Complement deficiencies result in susceptibility to infections by what organism? |
|
Definition
|
|
Term
| Interferon is produced in response to what? |
|
Definition
|
|
Term
|
Definition
* Inhibit viral spread
* Activation of antigen-presenting cells
* Activation of NK cells |
|
|
Term
| Which interferon provides the most resistance to viral infection? |
|
Definition
|
|
Term
| Which interferon generates the greatest immune response? |
|
Definition
|
|
Term
| What type of interferon is used to treat heptatitis B and C viral infections? |
|
Definition
|
|
Term
|
Definition
| Activate complement (mannan-binding lectin is an example of a collectin) |
|
|
Term
| Function of C-reactive protein |
|
Definition
* Activate complement
* Opsonization |
|
|
Term
| Protection against encapsulated bacteria (eg, S. pneumoniae) infections is mainly provided by antibodies or complement? |
|
Definition
|
|
