Term
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Definition
- water balance homeotasis - regulates blood volume, maintaining proper water, salts, and acid/base balance - produces: renin, erythropoietin |
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Term
What is the function of renin? |
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Definition
- increases blood pressure - produced by kidney |
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Term
what is the function of erythropoietin? |
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Definition
- increases RBC production |
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Term
The kidney is in a ____ position in the ___ ___ region. |
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Definition
- retroperitoneal - superior lumbar |
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Term
The kidney extends from the ___ ___ vertebrae to the ____ ___ ___. |
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Definition
- 12th thoracic vertebrae - 3rd lumbar vertebrae |
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Term
The right kidney is close to the ___ and sits ___ than the left kidney. |
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Definition
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Term
The adult kidney weighs ___ grams and is ___ x ___ x ___. The lateral surface is ___, while the medial surface is ___. |
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Definition
- 150 - 5 in x 2.5 in x 1 inch - convex - concave |
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Term
The ___ ___ is found on the medial ___ surface of the kidney and leads to the ___ ___. |
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Definition
- renal hilus - concave - renal sinus |
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Term
Structures entering/leaving the hilus: |
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Definition
- renal veins - renal arteries - ureter and medial part of renal pelvis - lymphatic vessels - nerves
from anterior to posterior: renal vein, renal artery, ureter |
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Term
Supportive tissue of the kidney includes the fibrous ___ __ which adheres directly to the surface of the kidney. ___ fat acts a cushion from external blows. |
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Definition
- renal capsule - perirenal fat |
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Term
The ___ ___ of ___ is the outermost layer of dense, fibrous connective tissue, that anchors the kidneys and adrenal glands to surrounding structures. |
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Definition
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Term
The ____ fat is the outermost layer of fat that adheres to the posterior abdominal wall. Both fat layers give support to the kidneys and keep them in place. |
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Definition
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Term
from outermost to innermost linings of the kidneys: |
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Definition
- peritoneum > pararenal fat > renal fascia of gerota> perirenal fat> fibrous renal capsule> kidney |
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Term
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Definition
- when the kidney falls to a lower than normal position - can cause the ureter to kink, causing urine to back up in the kidney, leading to increased internal pressure = hydronephrosis - hydronephrosis means water in the kidney, can damage the kidney and lead to necrosis - often seen with anorexia b/c loss of supportive fat around the kidneys |
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Term
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Definition
- increased pressure in the kidney due to backed up urine from kinked ureter from ptosis of kidney - seen with anorexia |
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Term
Internal kidney. The __ ___ is the most superficial region. It has parts that dip down into spaces between pyramids to form __ ___. |
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Definition
- adrenal cortex - renal columns |
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Term
The cortex is lighter in color with a granular appearance. The renal medulla is deep to the cortex, with a ___ ____ color. |
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Definition
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Term
cone shaped masses are called: |
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Definition
- renal or medullary pyarmids |
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Term
Renal pyramids have a broad ___ that faces the cortex and a ___ aka ___ that points internally. |
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Definition
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Term
renal pelvis is formed by merging ___ ____. |
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Definition
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Term
___ ___ of ____ are inward extensions of cortical tissue and are found between the pyramids. |
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Definition
- Renal columns of Bertin |
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Term
what constitutes a renal lobe: |
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Definition
- renal pyramid with adjacent cap of cortical tissue and cortical columns |
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Term
papilla > minor calyx> major calyx> renal pelvis> ureter |
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Definition
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Term
walls of the calyces and renal pelvis contain ___ ___ for peristalsis. |
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Definition
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Term
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Definition
- infection of renal pelvis and calyces |
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Term
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Definition
- an infection or inflammatory condition that affects the entire kidney |
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Term
kidney infections in females: |
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Definition
- usually caused by fecal bacteria E.coli - usually spread from anal region to urinary tract |
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Term
sometimes kidney infections can result form ___ ___ bacteria. |
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Definition
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Term
Urinary tract infections are common in hospitals b/c of ____. |
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Definition
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Term
Renal arteries are large and deliver ___ of the total ___ ____ ___ to the kidneys every minute. They branch from the abdominal aorta at right angles and are between the __ and ___ vertebrae. |
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Definition
- 1/4 - systemic cardiac output - L1 and L2 |
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Term
so every 4 minutes the kidneys process the entire volume of your blood. |
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Definition
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Term
The ___ renal artery is longer than the ___ renal artery. |
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Definition
- right renal artery longer than left renal artery |
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Term
renal arteries usually branch into five ___ arteries. |
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Definition
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Term
more than 90% of the blood supply entering the kidney profuses the ___. |
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Definition
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Term
The ___ contains the bulk of nephrons. |
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Definition
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Term
renal veins follow the arterial pathway in reverse. |
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Definition
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Term
trace blood supply in kidney: |
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Definition
- renal artery> segmental arteries> interlobar arteries> arcuate arteries> interlobular arteries |
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Term
what three arteries contribute to afferent arterioles, trace the blood flow: |
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Definition
- interolobar, arcuate, and interlobular arteries>> afferent arterioles>>glomerulus> efferent arterioles> peritubular capillary network |
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Term
___ arterioles feed the glomerulus. |
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Definition
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Term
nerve supply to the kidneys and ureter: |
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Definition
Renal plexus and ganglion (branch off of celiac plexus and ganglion) |
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Term
Renal plexus is supplied by sympathetic fibers from: |
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Definition
- least thoracic nerve - first lumbar splanchic nerve |
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Term
Sympathetic fibers to the kidneys and ureters are ___ fibers that regulate ___ ___ ___ by adjusting the diameter of ___ ___. |
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Definition
- vasomotor - renal blood flow - renal arterioles |
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Term
Parasympathetic fibers from the posterior and anterior __ __ contribute to the ___ plexus. |
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Definition
- vagal trunk - celiac plexus |
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Term
structural and functional unit of the kidney: |
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Definition
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Term
The __ is responsible for urine formation. |
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Definition
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Term
over 1 million nephrons per kidney |
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Definition
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Term
majority of nephrons reside in the renal ___. |
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Definition
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Term
components of the nephron: |
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Definition
- a dilated renal corpuscle- Bowman's capsule - proximal convoluted tubule - loop of Henle - distal convoluted tubule
All of these structures together are called the renal tubule. So you could say the nephron is made up of renal tubule. |
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Term
Urine from several renal tubules drain into __ ___. |
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Definition
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Term
nephrons are supplied directly by the ___ ___. |
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Definition
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Term
The renal corpuscle is formed by the : |
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Definition
- glomerulus - Bowman's capsule |
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Term
A ___ is a tuft of capillaries found inside of Bowman's capsule. These two structures together are called a ___ ___. |
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Definition
- glomerulus - renal corpuscle |
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Term
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Definition
- end of the renal tubule - blind-ended, enlarged, and cup shaped tube - completely surrounds the glomerulus |
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Term
look at slide 34 of this lecture and understand. |
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Definition
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Term
Bowman's capsule is connected to the ___ ___ ___. |
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Definition
proximal convoluted tubule |
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Term
___ ___ feed the capillary bed aka ___ of the nephron. ___ ___ drain this capillary bed. |
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Definition
- Afferent arterioles - glomerulus - Efferent arterioles |
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Term
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Definition
- arise from efferent arterioles - are adapted for absorption of solutes and water - are found close to renal tubules - empty into interlobular veins of the renal venous system |
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Term
peritubular capillaries empty into: |
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Definition
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Term
not until the collecting duct is it considered urine, before then in PCT, loop of Henle, and DCT, it is filtrate. |
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Definition
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Term
Renal corpuslces are found only in the ___. |
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Definition
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Term
renal corpuscles represent the initial epanded part of the ____. |
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Definition
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Term
Renal corpuscles have a ___ pole and a ___ pole. |
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Definition
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Term
Each renal corpuscle consists of : |
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Definition
- epithelial part= Bowman's capsule - vascular part= glomerulus |
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Term
Bowman's capsule is a ___ ___ __that forms the corpuslce's ___ ___. |
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Definition
- double epithelial layer - external covering |
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Term
List the two epithelial layers of Bowman's capsule: |
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Definition
- Parietal layer: outer layer of simple squamous epithelium resting on a basal lamina - Visceral layer: inner layer of capsule consists of specialized cells called podocytes |
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Term
____ cover the capillary loops of the glomerulus and are in direct contact with the basal lamina of the glomerular capillaries. |
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Definition
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Term
___ ___ is between the parietal layer and visceral layer of Bowman's capsule. |
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Definition
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Term
look at slides 38 and 39 of this lecture for histology |
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Definition
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Term
Filtrate passes from the __ in ___ ___ to ___ ___. |
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Definition
- blood in glomerular capillaries - urinary space |
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Term
3 closely apposed structures of the renal corpuscle: |
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Definition
- glomerular capillary endothelium - basal lamina - visceral layer of Bowman' capsule with podocytes |
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Term
The lining of the glomerular capillaries is an ____ ____ with numerous ____. |
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Definition
- attenuated endothelium - fenestrae |
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Term
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Definition
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Term
External to the capillary endothelium is a continuous ___ ___ and ___ cover the outer endothelium. |
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Definition
- basal lamina - podocytes |
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Term
The filtration barrier of the renal corpuscle is formed by: |
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Definition
- fenestrated endothelial cells of glomerular capillaries - basal lamina- prevents passage of large cells - filtration slits b/w pedicels of podocytes (visceral layer of bowman's capsule) |
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Term
podocytes are highly specialized cells that form the ___ ___of ___ ___. |
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Definition
- visceral layer of Bowman's capsule |
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Term
Each podocyte has several ___ ___ called ____ that give rise to ___ ___ that terminate as ____. Adjacent ____ interdigitate and form a series of ___ __. A thin non-membranous diaphragm termed the slit membrane spans each filtration slit. |
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Definition
- primary processes called trabeculae - secondary processes - pedicels - pedicels - filtration slits |
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Term
look at slides 41-51 for histology |
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Definition
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Term
The proximal convoluted tubule is mainly in the ___ and is made of ___ ___ or ___ epithelium. Its apical border is a ___ ___ containing many ____. |
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Definition
- cortex - simple cuboidal or columnar - brush border - microvilli |
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Term
The cytoplasm of the proximal convoluted tubule contains many ____. The PCT is important for ___ and ___. |
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Definition
- mitochondria - absorption - transport |
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Term
The PCT absorbs macromolecules via ___ and uses ___ ___ __ out of cells. It absorbs all the ___ and ___ ___ and 85% of the ___ ___. Water ___ ___ following the ___ ___. |
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Definition
- pinocytosis - active sodium transport - glucose - amino acids - sodium chloride - diffuses passively - osmotic gradient |
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Term
90% of malignant kidney tumors are found where? |
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Definition
- proximal convoluted tubule |
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Term
The distal convoluted tubule is made of ___ ___ epithelium and does not have a ___ ___. It is located in the ___ of the kidney. |
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Definition
- simple cuboidal - no brush border - cortex |
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Term
The ___ __ is a modified portion of the distal convoluted tubule where it lies adjacent with the ___ __ of the renal corpuscle. |
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Definition
- macula densa - vascular pole |
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Term
___ acts on cells of the distal convoluted tubule to absorb more ___ and ___ ions. |
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Definition
- Aldosterone - sodium - chloride |
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Term
The juxtaglomerular complex is located near the ____ ___ of the ___ ___. |
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Definition
- vascular pole - renal corpuscle |
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Term
The ___ ___ limb of the ___ ___ __ contacts the vacular pole between the ___ and ____ arterioles. |
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Definition
- ascending thick - distal convoluted tubule - afferent and efferent arterioles |
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Term
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Definition
cluster of tightly packed cells in the DCT |
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Term
___ ___ of the afferent arteriole are modified smooth muscle cells that secrete ___. |
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Definition
- Juxtaglomerular cells - renin |
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Term
The DCT has the ___ __, while the afferent arteriole has the ___ ___ that secrete ___. |
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Definition
- macula densa - juxtaglomerular cells - renin |
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Term
Juxtaglomerular cells of the ___ ___ are modified ___ ___ cells that secrete ___. |
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Definition
- afferent arteriole - smooth muscle - renin |
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Term
Regulation of Blood pressure: - Renin acts on ___ ____ ___ producing ___ __. - A converting enzyme makes ___ __ from angiotension I. - ___ _ increases blood pressure by ___ ___ and stimulating ___ ___ from the ___ ___. - ___ acts on cells of the distal convoluted tubule to increase absorption of sodium and chloride ions. This expands fluid volume and blood pressure. |
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Definition
- plasma protein angiotension - Angiotension I - Angiotension II - Angiotension II - contricting arterioles - aldosterone secretion - adrenal glands - Aldosterone |
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Term
what interaction produces angiotension I? |
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Definition
- renin (from the juxtaglomerular complex in the afferent arteriole) acting on plasma protein angiotension |
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Term
converting enzyme converts what to what? |
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Definition
- angiotension I to angiotension II |
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Term
How does angiotension II increase blood pressure? |
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Definition
- constricts arterioles - stimulated aldosterone secretion of adrenal glands |
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Term
what does aldosterone do? |
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Definition
- acts on cells of distal convoluted tubule to absorb sodium and chloride ions - water follows> increased blood volume> increase blood pressure |
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Term
Loop of Henle: - thick descending loop is similar in structure to the ___. - thin descending loop is ___ ___ epithlium, in the ___ of the kidney - thin ascending loop is ___ ___ epithelium in the ___ of the kidney. - thick ascending loop is similar in structure to __. |
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Definition
- PCT - simple squamous, medulla - simple squamous, medulla - DCT |
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Term
The loop of Henle is permeable to ___ ___. |
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Definition
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Term
Ureters are long slender tubes that convey urine from the kidney to the urinary bladder. They begin at level of __ as a continuation of the ___ ___. They descend behind the ___to the base of the bladder, turn medial and then run oblique through posterior wall of bladder. Path prevents backflow of urine into ureters during bladder filling. |
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Definition
- L2 - renal pelvis - peritoneum |
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Term
3 sites of constriction of the ureter: |
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Definition
- uretopelvic junction- near hilus - where they cross the iliac vessels- pelvic brim - where they join the bladder |
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Term
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Definition
- mucosa - muscularis - adventitia |
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Term
describe the ureter mucosa: |
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Definition
- highly convoluted - thick transitional epithelium - continous with that of the kidney, pelvis, and urinary bladder |
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Term
describe ureter muscularis: |
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Definition
- two sheets: inner longitudinal , outer ciruclar, upper part is 2 sheets, lower part near bladder is 3 sheets |
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Term
describe ureter adventitia: |
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Definition
fibrous connective tissue covering |
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Term
Distention of the ureter by incoming urine stimulates: |
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Definition
- the muscularis of the ureter to contract> peristalsis, propells urine into bladder |
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Term
The vigor and frequency of the peristaltic waves are controlled by the rate of __ ___. |
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Definition
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Term
ureter has an inner ___ muscle layer and an outer ___ muscle layer. |
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Definition
- inner longitudinal - outer circular |
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Term
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Definition
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Term
Kidney stones are crystals of ___, ___, or __ __ ___. These are called ___ ___. They precipitate in the ___ __. Most are small, less than 5 mm, and pass undetected. Larger calculi can block a ureter and prevent urine passage. Causes pain in __ wall of __ from increased pressure in the kidney. |
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Definition
- calcium, magnesium, uric acid salts - renal calculi - renal pelvis - posterior wall of the abdomen |
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Term
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Definition
- frequent urinary tract infections (bacteria) and holding of urine - high blood calcium and alkaline urine |
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Term
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Definition
shock wave that shatters kidney stones |
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Term
prevention of kidney stones: |
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Definition
- acidifying the urine by drinking cranberry juice - ingesting lots of water to dilute urine |
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Term
The bladder is a smooth collapsible muscular sac that temporarily stores urine it is located ___ on the ___ ___, just posterior to the ___ ___. |
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Definition
- retroperitoneally - pelvic floor - pubic symphysis |
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Term
urinary bladder: Females - lies anterior to the vagina and uterus Males - lies anterior to the rectum and superior to the prostate gland that surrounds its inferior neck |
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Definition
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Term
three layers in bladder wall: |
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Definition
- mucosa - muscularis - adventitia |
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Term
describe mucosa of the bladder wall: |
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Definition
- transitional epithelium |
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Term
describe muscularis of bladder wall: |
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Definition
thick, muscular layer called the detrusor muscle consisting of intermediate smooth muscle fibers arranged in inner and outer longitudinal layers and a middle circular layer |
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Term
describe adventitia of bladder: |
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Definition
fibrous layer covers the bladder except on its superior surface superior surface covered by the parietal peritoneum |
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Term
Interior part of the bladder has three openings for: |
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Definition
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Term
smooth triangular region on base of bladder between the three openings is called the: |
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Definition
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Term
Between the two openings of the ureters is the: |
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Definition
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Term
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Definition
it collapses into its basic pyramidal shape |
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Term
Thick walls of urinary bladder form: |
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Definition
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Term
as urine accumulates the bladder: |
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Definition
- becomes pear shaped and rises superiorly - muscle wall stretches and rugae disappear - stretching triggers micturition/voiding |
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Term
normal capacity of bladder is 300-500 mL, cut can hold twice this. |
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Definition
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Term
The urethra is a thin walled muscular tube. Near the bladder it is ___ epithelium, then its mostly ___ ___ epithelium, then near its opening it becomes ___ __ ___ epithelium. |
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Definition
- transitional - pseudostratifed columnar - simple squamous non-keratinized |
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Term
in females the urethra is 1.5 inches long and bound to the vagina by fibrous connective tissue. |
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Definition
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Term
External urethral orifice aka meatus: |
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Definition
- external opening of urethra - anterior to vagina, posterior to clitoris |
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Term
In males urethra is 8 inches long and has three regions, list them: |
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Definition
- prostatic urethra - membranous urethra- goes through urogenital diaphragm(sphincter urethra muscle) - spongy (penile) urethra- passes through penis and opens at tip via external urethral orficice
MALE URETHRA CARRIES SEMEN AND URINE OUT OF BODY |
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