Term
| Why are corticosteroids given to women experiencing preterm labor? |
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Definition
| They assist with fetal lung maturation |
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Term
True or false:
A single course of steroids is the standard of care in women at risk for preterm birth |
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Definition
True
It has been the standard since 1994 |
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Term
| What are some contraindications to antenatal corticosteroids? |
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Definition
Active untreated infection
Traumatic brain injury
Hypersensitivity |
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Term
| Corticosteroid mechanism of action |
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Definition
1. Enhance maturational changes in lung architecture and accelerate morphologic development of fetal alveolar cells
2. Regulate enzymes that stimulate phospholipid synthesis and the release of surfactant
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Term
| What is the correct dosage/route of betamethasone? |
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Definition
12 mg IM
2 doses gievn 24 hrs. apart |
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Term
| What is the correct dosage/route of dexamethasone? |
|
Definition
6 mg IM
4 doses given 12 hrs apart |
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Term
True or false:
Adverse effects are LIKELY with antenatal corticosteroid use |
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Definition
False, adverse effects are rare with such short-term administration
Possible adverse effects include: restlessness, HTN, hyperglycemia, anorexia, n/v, hypokalemia, increased susceptibility to infection |
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Term
| What are some benefits of antenatal corticosteroid use? |
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Definition
Reduced risk of:
1. Neonatal death
2. Resp. distress syndrome
3. Intraventricular hemorrhage
4. Nectrotizing enterocolitis
5. Early sepsis |
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Term
| Is there any association with a single course of steroids and adverse neonatal events? |
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Definition
|
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Term
| What is the effect of corticosteroids on maternal glucose? |
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Definition
1. Increased glucose intolerance
2. Transient hyperglycemia |
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Term
| When corticosteroids are combined with tocolytics, pregnant women may be predisposed to _________ ________ |
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Definition
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Term
| What are the recommendations from ACOG and UpToDate regarding women at risk for preterm delivery? |
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Definition
1. ACOG says all women at risk between 26 and 34 wks should receive a course of steroids
2. UpToDate says all women at risk of delivering in the next 7 days should receive a course of steroids. They also recommend them for women with PPROM between 24 and 32 wks. |
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