Term
|
Definition
| Prostaglandin E1 analogue |
|
|
Term
Misoprostol
mechanism of action |
|
Definition
Produces uterine contractions
Decreases gastric acid secretion |
|
|
Term
|
Definition
1. Cervical ripening for induction of labor
2. Medical abortion with mifepristone
3. Prevention of gastric ulcers secondary to NSAID use
4. Treatment of duodenal ulcers (off-label)
5. Treatment of acute PPH (off-label) |
|
|
Term
| Contraindications to misoprostol use |
|
Definition
1. Hypersensitivity
2. Do not use during pregnancy for GI indications
3. Cervical ripening with prior c-section or other uterine surgery
4. Caution in pt. with CV disease or IBD |
|
|
Term
Misoprostol
dosage and route |
|
Definition
PO, rectally, sublingually, vaginally, or IM
Dosage range 400 to 1000 mcg |
|
|
Term
|
Definition
Diarrhea
Abdominal pain
Fever/chills
Nausea/vomiting
Tachycardia
Headache |
|
|
Term
| Advantages of misoprostol |
|
Definition
1. Very cost-effective
2. No significant contraindications
3. Fewer side effects than Hemabate
4. Not contraindicated in pt. with hypertension |
|
|
Term
ACOG Recommended
dosage of misoprostol |
|
Definition
*1st choice is always oxytocin
800 - 1000 mcg per rectum once |
|
|
Term
Recommended sublingual and oral doses
of misoprostol |
|
Definition
400 to 600 mcg PO
or
400 to 600 mcg sublingual |
|
|
