Term
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Definition
| General Recombination Enzyme, does initial base pairing then acts as an SSB |
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Term
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Definition
| Human equivalents to RecA, General Recombination |
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Term
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Definition
| Process by which DNA regions at site of crossing over recognize each other |
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Term
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Definition
| Single strand binding proteins, keep DNA open for recombination |
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Term
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Definition
branched intermediate structure that results from DNA strand exchange
between DNA helices. A Chi structure is a Holliday structure intermediate that looks,
microscopically, like the Greek letter chi. |
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Term
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Definition
| – location where strands from two different DNA helices have basepaired |
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Term
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Definition
| Accesory proteins that interact with RAD51, disrupting proper function is associated with breast and ovarian cancer |
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Term
| Transposition and Site-specific recombination |
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Definition
genetic exchange that occurs at short
nucleotide stretches and requires little or no homology. Here, mobile genetic elements
("jumping genes") are used |
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Term
| Transpositional recombination |
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Definition
- carried out by transposons (transposable elements),
mobile genetic elements that usually encode a transposase which insert into target DNA
without any homology requirement. |
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Term
| Conservative site-specific recombination |
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Definition
– involves a short heteroduplex joint and
therefore short DNA sequence homology for recombination. A classic example is the
integration and exit of bacteriaphage lambda into and out of its target E. coli genome |
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Term
| V(D)J (site-specific) recombination |
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Definition
– The combinatorial diversification of antibodies
resulting from the rearrangement of different combinations of antibody V, J, and D gene
segments in B-cells. This is mediated by an enzyme complex called the V(D)J
recombinase composed of RAG proteins. V(D)J recombination is also used to generate Tcell receptor diversity in T-cells |
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