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6C respiratory disease
Kims lecture
89
Nursing
Undergraduate 1
03/09/2010

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Term
Hypoxemia
Definition
decrease in arterial oxygen
Term
SA02
Definition
Saturation of oxygen on hemoglobin
--Normal = 95% to 100%
--Below 90% pt needs supplemental H20
Term
PA02
Definition
Partial pressure of oxygen in arterial blood.
--Mild Hypoxemia PA02 < 80mmHg
Term
Moderate Hypoxemia
Definition
< 60 mmHG
Term
Sever Hypoxemia
Definition
PA02 < 40 mmHg
Term
early Signs and Symptoms of Hypoxemia
Definition
Restless, Tachycardia, increased BP, anxiety, change in respiratory pattern.
Term
Lates signs & symptoms for Hypoxemia
Definition
Decrease in BP, cyanosis, lethargy, confusion, dyspnea, dysrhythmias, cool extremities, coma
Term
Chronic or Long-standing hypoxemia
Definition
Lethargy, inattention, apathy, delayed reaction time.
Term
Normal PaCAO2 (Partial pressure of carbon dioxiode)
Definition
35-45 mmHg
Term
Hypercapnia (hypercarbia)
Definition
PaCO2 > 45 mmgh
Term
S/Sx of Hypercapnia
Definition
Dilates blood vessels in the brain - felling of fullness in the brain.
-- inc. HR, inc RR, inc BP, headache, confusion, drowsiness, mental cloudiness, ventricular fibrillation, weaknes, dull headache.
Term
Hyposcapnia
Definition
Hyperventilation PaCO2 < 35 mmHg
Term
S/Sx of Hypocapnia/ Hyperventilation
Definition
-- Light headedness d/t vasoconstriction of cerebral blood vessels.
-- Inability to concentrate, numbenss and tingling in the extremities, tinnitus, and at times loss of consciousness
Term
Cyanosis
Definition
--caused by desaturation of the hemoglobin
--very late indicator of hypoxia
-- 5 or more grams per deciliter of desaturated hemoglobin.
Term
Bronchoscopy
Definition
Visualization of the tracheobronchial tree via a scope sent through the mouth/nose into the bronchi.
-- Therapeutic or diagnostic purposes.
-- remove foreign bodies, secretions, determine location of pathologic process, diagnose bleeding site, obtain tissue samples, excise or destroy lesions.
Term
Chest X-Rays
Definition
Provide info about chest that other assessment means cannot offer.
- as part of routine screening procedure
-when pulmonary diesease is suspected
-for confirmation of ET or trach tube placement.
-To monitor status of repiratory disorder and abnormalities
Term
Diagnostic Tests
Definition
MRI CT SCAN Pulomonary Angiography
Floursocpy
- use of x-rays to observe deep structures in motion.
Ultrasonogrpahy
- Especially useful for detecting 50ml or less of pleural fluid.
Term
Pulmonary Function test
Definition
-Spirometer is used to measure amounts of gas exchanged between the patient and the atmosphere.
-Used to detect abnormalities in the respiration and the extent of those abnormalities.
- Measures lung volumes, lung mechanics, and the diffusion capabilities of the lungs.
Term
4 types of lung scans
Definition
Perfusion, Ventilation, Inhalation Gallium.
-- used to detect normal lung functioning, pulmonary vascular supply and gas exchange
Term
Thoracentesis
Definition
-Aspiration of pleural fluid for therapeutic of diagnostic purposes.
- The fluid collected is sent to the laboratory and assessed for:
- specific gravity, glucose, protein, ph, culture, and sensitivity, and cytology
Term
Endoscopic Thoracoscopy
Definition
-Exploration of the pleural cavity by an endoscope
Term
DT - Sputum Collection
Definition
Goblet cells produce 100ml of mucus daily. Infection can inc. production.
- analysis of sputum for bacteria or tumor cells
- Culture and Sensitivity
-- Determine bacteria drug sensitivity
-- Start antibiotics only after the C&S is obtained
-Cytology: Examine Cells for malignancy
Term
TB Skin test
Definition
indicates exposure and antibody development to cmycobacterium tuberculosis; screening tool only, does not mean active disease is present.
Term
Arterial Blood Gas
Definition
precise measurment of acid-base balance and of the lungs ability to oxygenate the blood and remove excess CO2.
Term
ABG interpretation
Definition
PA02 80-100 mmHG. 02 delievered by the lungs to the blood
pH 7.35-7.45 Measures acidity or alkalinity of blood
PC02 35-45 mmHg. Amount of carbon dioxide in blood
HC03 22-26 mEq/L. Ion solution - regulated by the kidney. The metabolic parameter.
Term
Acid/Base Parameters pH
Definition
Acidic <7.35
Neutral 7.35-7.45
Alkaline >7.45
Term
Acid/Base Parameters PaCO2
Definition
Acidic >45
Neutral 35-45
Alkaline <35
Term
Acid/Base parameters HCO3
Definition
acidic <22
Neutral 22-26
Alkaline >26
Term
Interpreting ABG's
Definition
1st - assess the PaO2 first - hypoxic?
2nd - pH. acid or alkaline?
3rd - PCO2. acid or alkaline?
4th - HCO3. acid or alkaline?
Term
ABG's - Totally compensated
Definition
the pH will be within normal parameters
Term
ABG - Partially Compensated
Definition
the other system will be altered
Term
ABG's - Uncompensated
Definition
other system will be normal. (not trying to help.)
Term
What systems are responsible for ABG's and how do they respond?
Definition
Respiratory sytem is able to compensate quickly - minutes to an hour
The renal system is SLOW - Hours to days.
Term
Atelectasis
Definition
-Collapse or closure of alveoli
-Can be acute or chronic and have a broad range of pathophysiologic changes.
--Occurs most frequently postop. or with patients who have a shallow monotonous breathing pattern
Term
Atelectasis - Pathophys
Definition
-Absorptive atelectasis -Reduced alveolar ventilation or any type of blockage that impedes passage of air to and from alveoli
Term
Adhesive Atelectasis
Definition
Decreased surfactant production or loss of surfactant integrity
- Surfactant decreased surface tension, which allows the alvioli to stay open.
-Has short half-life and must be constantly replenished with normal ventilation.
Term
Atelectasis S&S
Definition
Cough, sputum production, and low grade fever. - Decreased breath sounds, crackles over affected area - CXR-"patchy or consolidated areas" - SaO2 - may be <90%, PaO2 may be low. - large area of lung tissue is involved may have marked respiratory distress - May also have dyspnea, tachycardia, tachypnea, pleural pain, and central cyanosis, anxiety
Term
Influenza
Definition
Acute viral respiratory infection
-Three types of virus -A,B, and C
Term
Influenza type A
Definition
responsible for the epidemics of repiratory illness that occur almost every winter and are associated with increase rates of hospitalization and death
Term
Influenza Type B
Definition
Frequently causes milder disease outbreaks
Term
Influenza Type C
Definition
infection usually causes either very mild respiratory illness or no symptoms at all.
Term
Influenza Pathophysiology
Definition
-aerosolized mucus droplets are shed from infected persons by caughing, talking or sneezing.
- Droplets penetrate the surface of the upper respiratory tract mucosal cells (eyes, nose, and mouth) and destroy cilliated epithelium and cause cell lysis
Term
SARS
Definition
Severe Acute Respiratory Syndrome
Term
SARS - Etiology
Definition
Spread by person to person contact through the air and possibly other ways which are not known yet.
- incubation period: 2-8 days
Term
SARS S&S
Definition
Elevated temp. >100.4
-Chills, headache, malaise, body pain, mild respiratory symptoms including caugh, SOB, dyspnea
3-7 days may develop: dry non-productive cough, dyspnea which may progress to hypoxemia.
10-20% pts require intubation and mechanical ventilation
Term
SARS Mortality
Definition
Approximately 13%
13% for patients <60 years old
43% for patients >60 years old
DX - CDC developing serum antibody tests
- Right now, diagnosis based on symptoms and exposures
Term
SARS Treatment
Definition
Maintain oxygenation and hydration
Prevent secondary infections
Meds:
-Corticosteroids and antibiotics
Term
Pneumonia
Definition
Inflammation of the lung parenchyma that is caused by a microbial agent... Bacteria, mycobacteria, chlamydiae, mycoplasm, fungi, parasites and viruses
Term
Pneumonia Pathophysiology
Definition
infectious particles reach the normally sterile lower respiratory tract -Affects both ventilation and diffusion. -Inflammatory reaction may occur in the alveoli and produces exudate that interferes with oxygen/carbon dioxide diffusion. - Neutrophils migrate to area and fill air containing spaces - Inadequate ventilation due to bronchial edema and secretion buildup.
Term
Lobar pneumonia
Definition
one or more lobes involved
Term
Lobar pneumonia
Definition
one or more lobes involved
Term
Bronchial pneumonia
Definition
distributed in a patch fashion
Term
Alveolar pneumonia
Definition
typically caused by a virus. Diffuse, bilateral involving the alveoli and interstitial spaces
Term
Tuberculosis
Definition
disease caused by mycobacterium tuberculosis. can affect any part of the body but usually attacks the lungs.
Term
TB pathophysiology
Definition
once inhaled the organisms implant themselves in the lung and begin dividing slowly.
-This causes inflammation, and development of primary tubercle, and eventual caseation and fibrosis
-Pulmonary macrophages and white cells migrate to infected areas, surrounding and isolating the bacilli and producing a lesion called a Ghon tubercle
-Scar tissue grows around the tubercle preventing further multiplicaiton, the bacilli become inactive forming a substance called caseation necrosis.
- isolated bacilli can remain dormant for life.
-if the pts immune system becomes impaired, live bacilli will escape into the bronchial tree and cause the patient to become contagious. this is called active TB disease.
Term
Tuberculosis DX
Definition
PPD skin test = determines antibody response to TB
Term
Pleurisy
Definition
Inflammation of the visceral and parietal membranes which rub together during respiration and cause pain.
Term
Pleurisy is caused by
Definition
Chest trauma, TB, Pneumonia, Chest surgery
Term
Pleurisy Signs & Systems
Definition
Knife like pain on inspiration.
Localized and radiates to shoulder or abdomen.
Term
Pleurisy TX
Definition
Treat cause and underlying condition.
Analgesics
Hot and cold application
anti inflammatory meds.
Splint chest wall when coughing
Intercostal nerve block for sever pain.
Term
Pleural effusion
Definition
Colleciton of fluid in the pleural space, resulting in decreased lung volume on the affected side.
-Pleural space normally has 15ml of fluid to keep surfaces lubricated an moving without friction.
Term
Pleural Effusion S&S
Definition
pleuritic pain that is sharp and increases on inspiration. Dyspnea. Tachycardia. Cough - productive or non-productive. Decreased breath sounds. impaired chest wall excursion. Chest xray can confirm but needs 200-300mls to be visualized.
Term
Pleural effusion TX
Definition
Thoracentesis (might be with) pleurodesis -- medicated shot. change position q 15 min to achieve uniform distribution
-May need chest tube. High fowlers position to promote ventilation. ABG, pulse oximetry.
Term
Pulmonary Embolism
Definition
Obstruction of the pulmonary artery or one of its branches by an emolus
Term
PE pathophys
Definition
When a thrombus occludes or partially occludes a pulmonary artery, the alveolar dead space is increased.
-Substances released from the clot cause blood vessels and bronchioles in the area to constrict. Can lead to right Ventricular failure due to increased workload.
Term
PE S%S
Definition
Dyspnea, Chest pain, Fever, Tachycardic, apprehension, Cough, Diaphoresis, sycope
Term
PE DX
Definition
Ventilation/Perfusion scan
Pulmonary angiography
Spiral/electron-beam cantrast CT or MRI
Peripheral Vascular studies
ABG's D-dimer lab assay
Term
PE TX
Definition
Anticoagulation therapy, Surgery-embolectomy. maintenance of blood pressure, 02, ABG's, oximetry, maybe ventrilator. IV meds -- DIG, antiarrythmics, diauretics, morphine, elevate HOB
Term
Chronic Obstructive Pulmonary Disease
COPD
Definition
air flow is obstructed by emphysema, chronic bronchitis or both.
- Progressive and irreversible and may associate with airway hyperactivity.
- Asthma may be part of COPD or its own disorder
Term
COPD Causes
Definition
Genetics- Lack of alpha 1 antitrypsin
Occupational exposure - Coal, cotton, grain
-Cigarette smoking -- PRIMARY CAUSE 80-90% of cases.
Term
Cystic Fibrosis
Definition
The lack of CFTR (a protein) causes improper regulation of the chloride channel and chloride is prevented from leaving the cells. Affects a wide reange of organs in the body
Term
Cystic Fibrosis effects on the body
Definition
NaCl concentration 5x normal
-Reproductive organs - 98% of men are infertile due to improper transport of sperm to semen.
GI- clogging of pancreatic ducts leads to enzyme deficiency in intestines
-Liver -- Billary obstruction, malnutrition, portal hypertension
Pancreas - Becomes fibrotic with decreased production of enzymes.
Term
Cystic Fibrosis S&S
Definition
failure to regain 10% of weight loss at birth
-failure to thrive
-protruding abdomen with atrophy of extremeties.
- Cardiac enlargement
-Presence of cough or wheezing during first 6 months of age
-decreased ability to absorb fat soluble vitamins
-clotting problems
-Retarded bone growth
-clubbing of fingers
Term
Cystic Fibrosis TX for pulmonary
Definition
Prevent infections
chest phiotherapy, CP, PD, humidification
Bronchodillators
Antibiotics
Expectorants
Term
GI problems: Cystic Fibrosis
Definition
Pancreatic enzymes
balanced nutrition, increased salt, increased calcium, double dose vitamins.
Term
Croup
Definition
Inflammation of the Larynx, trachea, and bronchi; usually preceeded by a 1-3 day cold.
Term
Croup
Pathophysiology
Definition
narrowing of air passages produced by edema. Usually viral
Term
Croup S&S
Definition
restlessness
"barking" cough
respiratory distress
hoarseness
inspiratory stridor (take a breath high pitched weezing)
High fever
nasal flaring
worse at night.
Term
Croup mild case TX
Definition
-can be treated at home
careful observation for symptoms of res. obstruction
-cool, humidified environment
-encourage fluid intake
-temperature reduction
-bedrest
Term
croup
severe TX
Definition
as previously listed
-oxygen
-iv fluids
-epinephrine for temp. relief
have endotracheal intubation equipment available
Term
Croup recovery
Definition
-usually 3-7 days
antibiotic for bacterial origin
Complications
-pneumonia
-Laryngospasm
Term
Epiglottitis
Definition
inflammation of the epiglottis and aryepiglottic folds usually resulting from Hemophilus influenza B
Term
Epiglottitis S&S
Definition
Abrupt onset
elevated temp.
Toxic appearance
Tachycardia, tachypnea
Thick muffled voice
sore throte
retractions
posture --> sitting up, leaning forward, open mouth and drooling
-red inflamed throat with distinctive cherry-red, edematous epiglottis.
2-5 yrs
Term
Epiglottitis
Definition
Therapeutic management
- Throat examine with extreme care.
- Antibiotics
- Respiratory isolation for 24hrs
- oxygen
- Vaccination. if child is > 24months disease should cause natural immunity
Term
Epiglottitis complications
Definition
OM, adenitis, meningitis, pericarditis, pneumonia
--Mortality 5-10%--
Term
Bronchiolitis
Definition
often caused by RSV (respiratory syncytial virus)
Term
Bronchiolitis S&S
Definition
first symptoms are like a cold
-Cough, tachypnea, and wheezing
-retractions
-fever
-dehydration
Term
Bronchiolitis
Therapeutic management
Definition
Cool mist
clear liquids
nasal saline drops and bubl syringe
Elevate HOB
Tylenol for fever
avoid Smoke
Careful observation of breathing
Term
Bronchiolitis
Hospital Management
Definition
IV, Antipyretics, Respiratory isolation, Epinephrine for sever stridor, Ribaviroan via aerosol (antiviral medication) to high risk groups
-intubation equipment on hand
-RSV immunoglobulin
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