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| what disease is a lack of nerve impulses and muscle responses at the myoneural (nerves in muscle endings) junction, causes fatigue and muscular weakness of the respiratory system, facial muscles, and extremities. |
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| neuromuscular disorder that attacks the myelin sheath of nerve fibers, causing lesions known as plaques. |
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| Myasthenia gravis is an autoimmune disorder that results from a lack of |
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Definition
| acetylcholine (ACh) receptor sites |
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| The group of drugs used to control MG is |
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| AChE inhibitors, also called cholinesterase inhibitors and anticholinesterase, |
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| AChE inhibitors are classified as |
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1. When the nurse explains the pathophysiology of myasthenia gravis to a client, which is the best explanation?
a. Degeneration of cholinergic neurons and a deficit in acetylcholine leads to neuritic plaques and neurofibrillary tangles.
b. Decreased amount of acetylcholine to cholinergic receptors produces weak muscles and reduced nerve impulses.
c. Myelin sheaths of nerve fibers in brain and spinal cord develop lesions or plaques.
d. Imbalance of dopamine and acetylcholine leads to degeneration of neurons in midbrain and extrapyramidal motor tracts. |
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2. For the client receiving pyridostigmine administration, the nurse should monitor for which adverse reaction?
a. Hypertension
b. Bronchospasm
c. Thrombocytopenia
d. Stevens-Johnson syndrome |
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4. A client with multiple sclerosis is in the chronic progressive phase. The nurse should expect which drug to be most helpful at this time?
a. Interferon β-1a (Avonex, Rebif)
b. Glucocorticoids
c. Azathioprine (Imuran)
d. Cyclophosphamide (Cytoxan) |
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