Term
|
Definition
| juvenile rheumatoid/idiopathic/chronic arthritis |
|
|
Term
| What are the 3 major subsets of JRA? |
|
Definition
-systemic
-polyarticular
-oligoarticular |
|
|
Term
| What are s/s of systemic JRA? |
|
Definition
-***fever
-rashes
-lymph node enlargement
-weight problems
-inflammation: kidneys, lungs, eyes, GI tract, heart |
|
|
Term
| Polyarticular JRA involves ___?___ or more joints in the 1st ___?____ months. |
|
Definition
|
|
Term
| Polyarticular JRA involves both large and small joints. Inflammation of the low and mid-back is ___?___ while inflammation of the neck/C-spine is ___?___. |
|
Definition
|
|
Term
| What are some systemic s/s of polyarticular JRA? |
|
Definition
-low-grade fever
-wt loss
-decreased appetite
-mild lymph node enlargement
-low-grade anemia
-RARELY heart, lung, kidney involvement |
|
|
Term
| What is another term for oligoarticular JRA? |
|
Definition
|
|
Term
| Oligoarticular JRA involves ___?___ or fewer joints in the 1st ___?___ months. |
|
Definition
|
|
Term
| What are common sites of inflammation in oligoarticular JRA? uncommon sites? |
|
Definition
common:
-hips
-knees
-ankles
-toes
-shoulders
uncommon:
-hands
-wrists
-elbows |
|
|
Term
| What are features of Pauci I? |
|
Definition
-girls
-<5 yo
-knees
-ANA + (antinuclear antibody)
-iritis/iridocyclitis |
|
|
Term
| What are features of Pauci II? |
|
Definition
-boys
-late school age or adolescent
-HLBA-B27 + (human leukocyte antigen) |
|
|
Term
| All forms of JRA are associated with eye inflammation. true/false |
|
Definition
|
|
Term
| What type of JRA most commonly involves eye irritation? |
|
Definition
|
|
Term
| What are classes of medications that treat JRA? |
|
Definition
-NSAIDs
-DMARDs (dz-modifying antirheumatic drugs)
-biologics
-steroids |
|
|
Term
| What are examples of DMARDs? |
|
Definition
-hydroxycholoroquine
-sulfasalazine
-leflunomide
-methotrexate |
|
|
Term
| Which DMARD is NOT used in kids? Why? |
|
Definition
leflunomide
can stay in system for 2 yrs and is teratogenic |
|
|
Term
| Which DMARD is teratogenic but is used in kids? |
|
Definition
|
|
Term
| What is the caution in treating JRA with steroids? |
|
Definition
|
|
Term
| What are the classes of biologics used to treat JRA? |
|
Definition
-TNF-alpha blockers (tumor necrosis factor)
-IL1 Inhibitor
-IL6 Inhibitor |
|
|
Term
| What are examples of TNF-alpha blockers? |
|
Definition
-etancercept (Enbrel)
-adalimumab (Humira)
-infliximab (Remicade) |
|
|
Term
| Which TNF-alpha blocker is also approved to treat Crohn's? |
|
Definition
|
|
Term
| What is an example of an IL1 inhibitor? |
|
Definition
|
|
Term
| What is an example of an IL6 inhibitor? |
|
Definition
|
|
Term
| More than ___?___ % of people with lupus are female. |
|
Definition
|
|
Term
| Lupus usually develops bw ___?___ and ___?___ yo, but can occur at any age. |
|
Definition
|
|
Term
| What are vaccination precautions for children with lupus or whose caregivers have lupus? |
|
Definition
|
|
Term
| What are some medications used to treat lupus? |
|
Definition
-hydroxychloroquine (Plaquenil)
-mycophenolate mofetil (Cellcept)
-cyclophosphamide (Cytoxan)
-rituximab (Rituxan)
-azathiprene (Imuran)
-IVIG
-steroids
-belimaumab (Benlysta) |
|
|
Term
| What are the s/s of MCTD (pediatric mixed connective tissue d/o)? |
|
Definition
-arthritis
-scleroderma
-dermatomyositis
-lupus |
|
|
Term
|
Definition
| presence of antibodies to nuclear proteins (RNP) |
|
|
Term
| Pediatric MCTD occurs in children under ___?___ yo and is more common in boys/girls/ |
|
Definition
|
|
Term
| Pediatric MCTD occurs in children under ___?___ yo and is more common in boys/girls? |
|
Definition
|
|
Term
| What are the 2 most common findings in MCTD? |
|
Definition
-arthritis
-Raynaud's phenomenon |
|
|
Term
| What are classes of medication used to treat MCTD? |
|
Definition
-NSAIDs
-steroids
-immunosuppressives
-Ca channel blockers for Raynaud's |
|
|
