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4) Ch 32 - antitubulars,antifungals,peptides
FSCJ Nursing program
22
Nursing
Undergraduate 3
10/27/2011

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Term
INH contraindications
Definition
Severe renal or hepatic disease, alcoholism, diabetic retinopathy
Term
While taking INH, you need to take a supplement for which vitamin since INH destroys it in the body?
Definition
B6
Term
INH side adverse reactions
Definition
Psychotic behavior, peripheral neuropathy, vitamin B6 deficiency
Term
antitubercular drugs are always used in ______ therapy, not by themselves
Definition
multidrug
Term
When isoniazid (INH) is prescribed, ______ (b6 supplement name) may also be prescribed to avoid deficiency and possible occurrence of peripheral neuropathy.
Definition
pyridoxine
Term
 First-line antitubercular drugs-Multidrug treatment is the most effective so its theTREATMENT REGIMEN OF CHOICE because its MORE_______AND LESS _____ THAN THE SECOND-LINE DRUGS.
Definition
effective, toxic
Term
Antifungal drugs, also called ______ drugs, are used to treat fungal infections.
Definition
antimycotic
Term
The antifungal drugs are classified into the following groups
Definition
Polyenes (e.g., amphotericin B, nystatin)

• Azoles (e.g., ketoconazole)

• Antimetabolites (e.g., flucytosine)

• Echinocandins (e.g., caspofungin)

• Antiprotozoals (e.g., atovaquone)
Term
Polyenes drug example
Definition
Amphotericin B
Term
antifungal drug of choice for treating severe systemic infection is
Definition
amphotericin B
Term
Side effects for amphotericin B
Definition
flush, fever, chills, nausea, vomiting, hypotension, paresthesias, and thrombophlebitis
Term
adverse reactions for amphotericin B include
Definition
nephrotoxicity and electrolyte imbalance,
Term
amphotericin B serum tests
Definition
Urinary output, blood urea nitrogen, and serum creatinine levels need to be closely monitored.
Term
what are peptides?
Definition
Peptides are derived from cultures of Bacillus subtilis, and this group appears to interfere with bacterial cell membrane function.
Term
peptide adverse reactions
Definition
nephrotoxicity and neurotoxicity.
paresthesias (abnormal sensations such as numbness, tingling, burning, and prickling) and dizziness.
Term
A Nurse teaching plan for peptides would include:
Definition
Have a patient report GI upset, diareah, numb/tingling sensations, decreased U output, IV site tenderness
Term
1. A client is beginning isoniazid and rifampin treatment for tuberculosis. The nurse gives the client which instruction?

a. Do not skip doses.

b. Take the drugs t.i.d. with food.

c. Take an antacid with the drugs to decrease GI distress.

d. Take rifampin initially, and then begin isoniazid after 2 months.
Definition
A
Term
2. A client taking isoniazid is worried about the side effects/adverse reactions. The nurse realizes that which is a common adverse reaction of isoniazid?

a. Ototoxicity

b. Hepatotoxicity

c. Nephrotoxicity

d. Optic nerve toxicity
Definition
B
Term
3. The nurse teaches the client taking amphotericin B to report which signs and symptoms to the health care provider?

a. Blindness

b. Loss of hearing

c. Nephrotoxicity

d. Stevens-Johnson syndrome
Definition
A
Term
4. A client with a diagnosis of intestinal amebiasis develops severe nausea, vomiting, fever, facial flushing, slurred speech, tachycardia, hypotension, and palpitations. A beginning assessment reveals that the client has just had several alcoholic beverages. The nurse should obtain a drug history for which drug?

a. bacitracin (Baci-IM)

b. fluconazole (Diflucan)

c. metronidazole (Flagyl)

d. ethambutol (Myambutol)
Definition
C
Term
5. A client has developed vaginal candidiasis. The nurse knows that which medication is appropriate treatment for this condition?

a. terconazole (Terazol-3)

b. haloprogin (Halotex)

c. terbinafine (Lamisil)

d. tolnaftate (Aftate)
Definition
A
Term
6. A client has been diagnosed with tuberculosis and is to begin the antitubercular medications isoniazid, rifampin, and ethambutol. What should the nurse do? (Select all that apply.)

a. Encourage periodic eye examinations.

b. Instruct client to take medications with meals.

c. Suggest that client take antacids with medications to prevent GI distress.

d. Advise client to report numbness and tingling of hands or feet.

e. Alert client that body fluids may develop a red-orange color.

f. Teach client to avoid direct sunlight and to use sunblock.
Definition
A,D,E,F
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