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O2 delivery = blood flow (CO) x [O2]
O2 delivery = CO x (dissolved O2 + Hb-O2) |
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2% transported as dissolved
98% transported via reversible binding to hemoglobin |
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| MetHb: disease state that has more ferric (Fe 3+) iron, hard time carrying O2…usually only about 1.5% because of methemoglobin reductase |
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Definition
| O2 carrying capacity = (1.34 ml 02 / gm Hb x 15 gm of Hb / 100ml) = 20 ml 02 / 100m |
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| O2 content= (capacity x % saturation) + dissolved O2 |
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| When blood leaves lungs, it is almost 100% saturated, a little admixture from cardiac veins and other sources. Comes back 75% saturated, only drop off 25% of O2. Called preloading, most Hb has 3 O2 already, very easy for 4th O2 to hop on. Also is reserve supply for strenuous activity. |
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Definition
Effect of CO on the curve (flat @ 50% in example)
Decreases O2 bound to Hb and decreases O2 carrying capacity
Left shift for O2 XX
Heme groups with higher affinity for O2 (does not release) |
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Term
| Factors affecting total CO2 carriage |
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Definition
Depends on:
PCO2
Plasma pH
PO2 |
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Term
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Definition
At any PCO2, CO2 content increases with decreasing PO2—uplifting of the curve
As O2 leaves at the tissue level-----increase ability to carry CO2
“Flip-side” of the Bohr pH and CO2 effect at the alveolar level----where increasing CO2/pH result in increased affinity for O2
Haldane effect of O2 on CO2 (As PO2 increases, CO2 carrying capacity decreases---release CO2) |
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