Term
| Acute inflammation is ------mediated |
|
Definition
IgE mediated (aactivated by allergen)
-Histamine
-Eicosanoids
-ROS(reactive oxygen species)
-macrophage,mast cell activation |
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Term
| Chronic inflammation is ______mediated |
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Definition
-Epithelial cells
-Eosinophils
-Lymphocytes
-mast cells, macrophages,neutrophils |
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Term
| Th1 lymphocytes are responsible for |
|
Definition
|
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Term
| Th2 lymphocytes are responsible for |
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Definition
|
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Term
| chronic inflammation leads to |
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Definition
matrix fibrosis
-inc smooth muscl bronchial hyperresponse
inc mucus gland mass production
-angiogenesis |
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Term
| Normal spirometry tests do not |
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Definition
|
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Term
| Used instrument for ASTHMA DIAGNOSIS |
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Definition
| PEF-Peak Expiratory Flow meter(where spirometry not available) |
|
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Term
|
Definition
|
|
Term
Chronic asthma FEV1/FVC ratio
ADULT NORMAL
CHILD NORMAL |
|
Definition
ADULT NORMAL- >0.75-0.8
CHILD NORMAL- >0.9 |
|
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Term
|
Definition
|
|
Term
Spirometry measures of CHRONIC ASTHMA
ADULT
CHILD |
|
Definition
ADULT >12% and 200mL from baseline
CHILD >12% predicted |
|
|
Term
Asthma exacerbation=
O2 sat
Lung Func Test |
|
Definition
O2 sat= <90-92%
Lung Func Test PEF or FEV1 <80% below baseline |
|
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Term
|
Definition
Sx: wheeze,cough,SOB,Tight chest
Physical: pale/cyanotic skin,accessory muscle use,wheeze,tachycardia |
|
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Term
|
Definition
CHILDHOOD ONSET
FAM HX OF ALLERGIC DISEASE
(EOSINOPHILIC) |
|
|
Term
ALLERGIC ASTHMA RESPONDS WELL TO _______
-NON ALLERGIC ASTHMA DOSE NOT |
|
Definition
|
|
Term
|
Definition
ADULT ONSET
NEUTROPHILIC/EOSINOPHILIC/FEW INFLAMMATORY CELLS |
|
|
Term
|
Definition
ADULT ONSET (MOSTLY WOMEN)
NON ALLERGIC
-NEEDS HI DOSE ICS OR ICS MAY NOT WRK |
|
|
Term
iNHALED DRUGS ARE _____-____% DEPOSITED IN LUNGS
THE REST IS ABSORBED ORALLY |
|
Definition
|
|
Term
| THE DRUG CLASS USED IN BOTH COPD & ASTHMA |
|
Definition
CORTICOSTEROIDS
B-2 AGONISTS
MUSCARINIC RECEPTOR ANTAGONISTS
THEOPHYLLINE |
|
|
Term
| GCs BIND TO GR TO INHIBIT HAT ACTIVITY BY_________ |
|
Definition
| RECRUITING HDAC2(REVERSES HISTONE ACETYLATION & DEC INFLAMMATORY GENE EXPRESSION) |
|
|
Term
CORTICOSTEROIDS CLEARANCE IS ______
ORAL BIOAVAILABILITY IS _____________ |
|
Definition
CORTICOSTEROIDS CLEARANCE IS LOW
ORAL BIOAVAILABILITY IS HIGH |
|
|
Term
| CORTICOSTEROID SIDE EFFEX |
|
Definition
-FLUID DISTRUBANCE/ELECTROLYTE
-OSTEOPOROSIS/GROWTH RETARDATION
-THINNING SKIN BRUISING/SLOW WOUND HEAL
-MOOD/BEHAVIOR
-CUSHHING SYNDROME(SUPRESSED HPA AXIS--CORTISOL SUPPRESSION) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| MOMETASONE FUROATE (75%ORAL BIO) |
|
|
Term
|
Definition
| METHYLPREDNISOLONE (99% ORAL BIO) |
|
|
Term
|
Definition
| RADIORECEPTOR ASSAY= DRUGS AFFINITY FOR GC RECEPTOR |
|
|
Term
| CORTICOSTEROIDS ARE METABOLIZED THRU |
|
Definition
CYP3A4
(KETOCAONAZOLE-->>POTENT INHIBITOR OF CYP3A4.INC PLASMA CONC OF ICS) |
|
|
Term
|
Definition
INCREASE IN
-GLUCONEOGENESIS
-HR
-RELAXATION IN LUNGS/UTERUS
-SKEL MUSC POTASSIUM UPTAKE/CONTRACTABILITY |
|
|
Term
| SHORT ACTING BETA 2 ADRENERGIC RXs |
|
Definition
EPINEPHRINE (SELECTIVITY low)
ISOPROTERENOL (SELECTIVITY low)
TERBUTALINE (SELECTIVITY high)
ALBUTEROL |
|
|
Term
| LONG ACTING BETA 2 AGONISTS |
|
Definition
-SALMETEROL
-FORMOTEROL
-OLODATEROL
-INDACATEROL
-VILANTEROL |
|
|
Term
|
Definition
-ALBUTEROL
-LEVALBUTEROL
-TERBUTALINE |
|
|
Term
|
Definition
TREMOR
TACHYCARDIA
HYPERGLYCEMIA
HA,PAIN,DIZZINESS |
|
|
Term
|
Definition
CYP3A4(KETOCONAZOLE/RITONAVIR)
MOAs
BETA BLOCKERS (PRODUCE SEVERE BRONCHOSPASM BY BLOCKING BETA AGONIST EFFECTS)
DIGOXIN (MAY DEC DIGOXIN LEVELS)
DIURETICS(POTENTIATES HYPOKALEMIA) |
|
|
Term
| THEOPHYLLINE(METHYLXANTHINES) BRONCHODILATION DUE TO |
|
Definition
|
|
Term
| iNC CL OF THEOPHYLLINE BY |
|
Definition
-SMOKING
-INDUCING CYP1A2
-CHILDHOOD
-HI PROTEIN,LOW CARB DIET
-BARBECUED MEAT |
|
|
Term
|
Definition
| CYP1A2 INHIBITON(CIMETIDINE,ERYTHROMYCIN,ALLOPUR, ZAFRILUKAST) |
|
|
Term
| THEOPHYLLINE SIDE EFFECTS |
|
Definition
NV
HA
DIURESIS
CARDIAC ARRYTHMIAS
BEHAVIOR DISTURBANCE/SEIZURES |
|
|
Term
|
Definition
| TX OF PT WITH SEVERE COPD AND HX OF EXACERBATION |
|
|
Term
|
Definition
-INC cAMP
-SMOOTH MUSCLE RELAX
-DEC INFLAMM
-DEC BRONCHOCONSTR
-DEC NEUROPEPTIDE RELEASEIN PULM SENS NERVES |
|
|
Term
| ROFLUMILAST SIDE EFFECTS & PK |
|
Definition
ND
HA
WEIGHT LOSS
PK:CYP1A2 & CYP3A4 CONTRA IN MOD-SEVERE HEPATIC IMPRMENT |
|
|
Term
|
Definition
ACT AT LTD2,LTE4,LTC4 TO HALT PROD OF BRONCHOCONSTRCT,MUCUS SECRET,PLASMA EXUD,EOSINOPHIL RECRUITMENT
ZAFRILUKAST
MONTELUKAST
ZILEUTON |
|
|
Term
| ANTI CHOLINERGICS(MUSCARINIC RECEPTOR ANTAGONISTS) |
|
Definition
TIOTROPIUM,IPATROPIUM,ACLIDINIUM,GLYCOPYRROLATE
(IPATROPIUM HAS A BAD TASTE)
NEBULIZED CAUSES GLAUCOMA
CAN CAUSE DRY MOUTH
-URINARY RETENTION
-BRONCHOCONSTRCTION WHEN USED WITH BENZALKONIUM |
|
|
Term
|
Definition
OMALIZUMAB,MEPOLIZUMAB,DUPILUMAB
-DONT USE IN ASTHMA
-DONT STOP CORTICOSTEROIDS ABRUPTLY
-STOP IF FEVER,RASH,JOINT PAIN DEVELOPS |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| GLY16GLY GENE IN ADRB2 SHOWS |
|
Definition
| BETTER RESPONSE THAN ARG16ARG GENE TO SABA |
|
|
Term
| ADRB2 DOES NOT SHOW DIF BETWEEN GLYGLY AND ARGARG FOR _________ |
|
Definition
|
|
Term
| CRHR1 SHOWS BETTER LUNG FUNC IN ADULTS AND PEDS W/ HOMOZYGOUS |
|
Definition
T/T & A/A (RS242941 & RS1876828)
WITH INHALED CORTICOSTEROIDS |
|
|
Term
| SNPs IN CRHR1 DECREAS ______________ |
|
Definition
| ENDOGENOUS CORTISOL AND IMPROVES PT SENSITIVITY TO ICS |
|
|
Term
| GUIDELINES AND LABEL UPDATES FOUND WHERE???? |
|
Definition
PHARMGKB
CPIC
DUTCH GUIDELINES
FDA |
|
|
Term
| TRANSLATE LAB GENOTYPE RESULTS |
|
Definition
GENETIC TESTING REGISTRY
PHARMGKB
CLINVAR
PUBMED |
|
|
