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407 exam4
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98
Biology
Undergraduate 4
05/04/2014

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Term
Exclusively breastfed infants <6 consume on average ---milk
Definition
26 ounces (3 1/2 c) milk/day during the first 6 mo postpartum = 572 kcal/day
Term
Older infants (> 6 mo) consume --milk
Definition
20 oz (2 1/2 c) milk/day in the second 6 mo postpartum = ~ 440 kcal/day
Term
Appropriate positioning on are important:
Definition
Latch, suck, swallow
Term
Poor technique can lead to
Definition
sore nipples
milk not removed= engorgement= decrease production
Mastitis
fussy baby
Term
engorgement
Definition
diff for baby to latch and suck
Term
mastitis
Definition
infection caused by engorg. or plug duct
Term
fussy baby
Definition
less likely to continue nursing/formula
Term
resources for women w/nursing probs
Definition
La lecha legaue- encouragement, info, personal help
certified lactation consultants- health care prof cert. in lactation
Term
amount of milk vs breast size
Definition
not connected-size is determined by fat not functional alveoli
Term
breast reduction probs
Definition
cant just remove fat, meses w/nerves milk ejection reflex damage
Term
breast implants and nursing
Definition
implants under or above pec muscle no disruption
Term
milk nutr
Definition
come from diet, composition is consistent independent of mom diet
amount of Ca in mom diet does not influence Ca level in milk
Term
bm caffeine
Definition
Cause some babies to be wakeful, hyperactive, and fussy
< 5 cups/day considered OK
Term
Alcohol maternal blood enters HBM
Definition
Takes 2-3 hours after a drink to have “nonalcoholic” milk
Recommendation - drink alcohol after nursing, not before.
Term
Nicotine
Definition
Better to smoke and breastfeed than to smoke and not breastfeed.
Term
vit k
Definition
low in bm, given shot at birth
Term
vit d
Definition
supps @2m
deficiency leads to rickets
Term
breast pumping=
Definition
expressing
Term
bm fridge/froze
Definition
fridge 48h
frozen 3-6m
Term
wet nurse
Definition
hired breast fed, making come back
Term
why would some1 not want to buy from breast milk bank
Definition
strict guidelines, pasteruized
300-1200$
Term
American Academy of Pediatrics Recommends
Definition
exclusively first 6m
throughout first year and as long as mutually desired
Term
BF rates
initiate
continued at 6m
12m
Definition
77
47
26
Term
why pppl stop bf?
Definition
46% mom have probelms
baby no satisfied
not enough milk
baby wouldnt nurse
uncomfortable
Term
women expectation of BF
Definition
easy and simple, not prepared for challenges and discomfort
Term
working and BF
Definition
doesn't affect initiation but does duration
after 3m 1/3 w return to work
Term
lactational/postpartum amenorrhea
Definition
delay of return of menstration /fertility= natural contraception + iron levels
helps lose weight
protect from breast/ovarian/endometrial cancer
Term
onset of breast dev=
Definition
thelarche,
Term
thelarche coincides w/
Definition
rise in estrogen and progesterone (promotes dev. and fat), first noticed as breast bud on either side
Term
what inhibits breast dev in males
Definition
testosterone.
can get brest bud tho
Term
at end of puberty breasts
Definition
fully mature but inactive state
Term
breast density
Definition
fibrous, glandular tissue ratio to fat
more dense in young
Term
breast are more dense-
Definition
prior to onset of menses
during breast feeding
hormone replacement therapy
Term
sag=
Definition
ptosis
easier to detect cancer bc less dense more fat
Term
breast neoplasm
Definition
abnormal mass of tissue
benign- cells still grow but self contained and wont spread
Term
w 20-50y most common benign breast disorder
Definition
fibrocystic changes- related to menstrual hormone changes. fluid filled cysts w/out sharply defined edges
Term
fibroadenoma
Definition
benign
hard lumps 1-2in fibrous/glandular tissue
move under skin when touched
Term
metastatic breast cancer rates
Definition
tripled in last 40y
Term
breast cancer occurs
Definition
30% all w cancers
1 in 8 w
Term
signs of breast cancer
Definition
red pitting skin, like an orange
changed areola color
change in breast contours
discharge/bleeding
most common: lump/thickening often painless
Term
inflammatory breast cancer
Definition
rare, fast growing, no lump
skin= thick, red, pitted orange, rash
Term
most common type of breast cancer
Definition
ductal, lining of milk duct
Term
noninvaisive (in situ) cancer
Definition
cancer cells hasvent invaded surrounding tissue
Term
invasive breast cancer
Definition
cells spread outside duct or lubule into tissue
Term
metastatic breast cancer
Definition
spread to other body parts: bone(most common), lung, liver, brain
Term
is a lump cancer?
Definition
must do biopsy: tissue sample
Term
lumpectomy
Definition
lump and area around removed, breast conserved
Term
mastectomy
Definition
entire breast removed
Term
heridary rate of breast cancer
Definition
5-10%
Term
genes inherited
Definition
from mom or dad
Term
BRCA
Definition
tumor supresser genes, repair DNA
Term
risk of getting breast cancer
Definition
99% not inherited
female
age
high breast density
not having child/bf
Term
breat canc. increases w/lifetime exposure to estrogen
Definition
eary puberty, late menopause, hormone replacement therapy, DES
Term
trend in thelarchy
Definition
occurs 1-2y sooner than 40 yr ago
Term
precocious puberty
Definition
early thelarche (7y) first sign
Term
HRT
Definition
never tested to provide disease protection
Term
womens health initiative
Definition
test menopausal hormones
2 groups
1- hysterectomy- estrogen, placebo
2- estrogen progesterone placebo
Term
w w/ no hysterectomy got estrogen and progesterone
Definition
bc estrogen alone increase uterine cancer
Term
Women who took estrogen alone (prescribed to women who do not have a uterus) compared with women taking a placebo.
Definition
Concluded – neutral risk
Term
Women given combination of estrogen and progestin (prescribed to women with a uterus) compared with women taking a placebo
Definition
Concluded – risk was one of harm
Term
HRT recommendations
Definition
only be given to women in menopause transition, the smallest amount for the shortest period of time.
Term
Trends since 1950 in age-standardized death rates comparing breast and selected other types of cancer, among women in the USA.
Definition
1. Early detection 2. Better screening 3. Improved treatments 4. With mass, routine screenings, detecting and treating breast cancers that are not clinically significant (grow slowly (or not at all), shrink or disappear on their own, and do not require treatment)
Term
What are the requirements for a good screening test
Definition
Simple, safe, cost-effective
Be able to detect a condition when treatment can affect outcome (reduction in the death rate from the disease)
The rate of false-positives must be low in order to prevent unnecessary procedures and treatments.
Term
Potential Methods of Early Breast Cancer Detection
Definition
Self breast examination (BSE)
Clinical breast examination (CBE) – no data
Breast imaging - Mammography
Term
Breast Self Examination – Shanghai Screening Breast Self Examination Study
Definition
Women BSE group had more biopsies, but there was no impact on breast cancer mortality.
Term
Breast cancer rates are increasing, while
Definition
breast cancer mortality rates are declining.
Term
universal mass screening of women in their 40s
Definition
Recommend no routine, individual chooses based on risk
Term
Routine mass screening begin
Definition
at age 50 for women at average risk, and that the time between mammograms in women 50 and over be extended to two years instead of one.
Insufficient evidence screening recommendations in those > 75 (y)
Term
Compression of morbidity
Definition
shortening the amount of time people live with functional decline.
Term
Iatrogenic
Definition
illness that is caused by a medication or physician. women have been more medicalized than men
Term
Live Expectancy
Definition
Determined as the age at which 50% of those born are still alive.
Term
today, women live-- their lives post menopausal
Definition
1/3rd (20-30)
Term
two stages of menopause transition
Definition
early (42)- high FSH, cycle regular but short
late (46)- skipped cycles, FSH increased, irradict hormones
Term
late stage is when women experience
Definition
Women often experience hot flashes, vaginal dryness, and mental/psychological symptoms during the late menopausal transition.
Term
hot flashes
Definition
most common symptom
begins 2y before FMP
rush of heat 1-5m, sweating vasodilation
Term
suspected cause of hot flashes
Definition
estrogen withdrawl or rapid fluctuation
Term
Menopause
Definition
1y after FMP
Term
decrease in estrogen -- bone loss
Definition
accelerates.
Term
osteoporosis
Definition
bones that have become increasingly porous, brittle, and subject to fracture.
Term
Osteoclasts
Definition
remove bone by dissolving the mineral and breaking down the matrix by a process called bone resorption.
Term
osteoblast
Definition
lay down bone in orderly layers that add strength to bone matrix.
Term
estrogen causes:
Definition
Thought that estrogen protects osteoblasts by stopping the action of an enzyme that triggers programmed death (apoptosis).
Term
bone structure
Definition
a honeycomb-like structure called trabecular bone and an outer dense layer of bone called cortical bone.
Term
thinning of -- bone makes bones weaker
Definition
cortical bone
fragility fractures associated w/low impact
Term
the loss of -- bone makes bone mechanically weaker
Definition
trabecular
compression fracture
Term
fragility fracture
Definition
any fall from standing height or less that results in a fracture
Term
trabecular bone less causes
Definition
compression fractures: kyphosis, hunched
Term
DEXA t-score
Definition
T-score is a comparison of a person’s bone density to that of average, young healthy adults of the same sex.
std deviations
Term
DEXA z-score
Definition
Z-score is the number of standard deviations above or below what is normally expected for someone your age, sex, weight, and ethnic/racial origin.
Term
Z-score lower than -2 suggests that
Definition
something other than aging is causing abnormal bone loss.
Term
The definition of osteoporosis changed from
Definition
an elderly person with a fracture to anyone with a T-score of -2.5 or more below
Term
Osteopenia
Definition
refers to low BMD, but not low enough to be considered osteoporosis.
Term
fosamax
Definition
first non hormonal drug to stop progressive bone loss
bisphosphonate
Term
fosamax leads to
Definition
jaw diesase- osteonecrosis
femoral fractures
taking 5y+ causes more brittle bones
Term
bisphosphonates-
Definition
inhibit osteoclast activity, but do not stimulate the production of new bone (osteoblasts).
Disruption of normal bone remodeling activity may cause over mineralization of bones that makes bones more brittle and prone to spontaneous breaks.
Term
Bisphosphonates (Fosamax) should be used only if
Definition
the risk of fracture within the next ten years is high enough to justify the potential risks.
Term
risk factors for osteoporosis are not in our control
Definition
Sex (female)
Age (menopause)
Race (Caucasian)
Family history
Frame size
Certain medications (some antidepressants, chemotherapy, and cortisone)
Term
Many things that can improve bone health and prevent bone loss are in our control:
Definition
Diet rich in calcium and vitamin D
Engage in weight-bearing exercise (minimum 150 min/wk)
Healthy lifestyle with no smoking or excessive alcohol intake
Smoking associated with early menopause
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