Term
What is the definition of drug abuse? |
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Definition
the non-medical use of a substance for any of the following reasons--psychic effect, dependence, or suicide attempt/gesture |
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Term
What is self administration? |
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Definition
the end result of drug-seeking behavior; used in animal models |
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Term
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Definition
can be stated in two ways: 1) the effect of a specific dosage decreases with repeated administration, or 2) a higher dosage is needed to produce the same effect with reapeated administration |
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Term
What is dispositional tolerance? |
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Definition
tolerance due to changes in the pharmacokinetic properties of the drug (absorption, distribution, metabolism and/or elimination) |
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Term
What is pharmacodynamic tolerance? |
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Definition
tolerance due to adaptive changes in teh affected systems |
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Term
Downregulation of receptors is an example of what type of tolerance? |
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Definition
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Term
What is behavioral tolerance? |
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Definition
an individual alters their behavior in order to adapt or compensate for the presence of a drug |
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Term
What word should replace the term "addiction" because it is more useful in understanding the components of drug abuse? |
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Definition
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Term
What is physical dependence? |
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Definition
the presence of "withdrawal" or abstinence syndrome, which is characterized by signs and symptoms usually opposite to those produced by the acute administration of the drug |
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Term
T/F Behavioral/psychological dependence can NOT occur independantly of physical dependence. |
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Definition
false; it can occur independently of physical dependence |
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Term
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Definition
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Term
What kind of drug is diethylpropion? |
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Definition
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Term
What type of drug is phenmetrazine? |
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Definition
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Term
What type of drug is phentemine? |
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Definition
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Term
Name some dissociative anesthetics. |
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Definition
ketamine, PCP (phencyclidine) |
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Term
Name the tryptamine hallucinogens. |
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Definition
dimethyltryptamine, hamine, lysergic acid, psilocin, psilocybin |
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Term
Name the phenalkylamine hallucinogens. |
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Definition
methylenedioxyamphetamine, methylenedioxymethamphetamine |
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Term
Name the phenethylamines hallucinogens. |
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Definition
dimethoxymethylamphetamine (DOM), and mescaline (peyote) |
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Term
Name some anticholinergic hallucinogens. |
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Definition
atropine, scopolamine, ditran |
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Term
What are the different types of hallucinogens? |
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Definition
tryptamines, phenalkylamines, phenethylamines, anticholinergics |
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Term
What kind of drug is alphaprodine? |
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Definition
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Term
What kind of drug is anileridine? |
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Definition
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Term
What type of drug is butorphanol? |
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Definition
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Term
What type of drug is levorphanol? |
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Definition
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Term
What type of drug is methadyl acetate? |
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Definition
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Term
What type of drug is nalbuphine? |
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Definition
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Term
What type of drug is pentazocine? |
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Definition
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Term
What type of drug is chlordiazepoxide? |
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Definition
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Term
What type of drug is chloral hydrate? |
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Definition
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Term
What type of drug is ethinamate? |
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Definition
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Term
What type of drug is gammahydroxybutyrate? |
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Definition
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Term
What type of drug is glutethiamide? |
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Definition
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Term
What type of drug is meprobamate? |
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Definition
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Term
What type of drug is paraldehyde? |
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Definition
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Term
What type of drugs are the aliphatic acelate? |
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Definition
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Term
What type of drugs are carbon tetrachloride? |
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Definition
solvent, volatile intoxicant |
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Term
What types of drugs are freon propellants? |
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Definition
solvents; volatile intoxicants |
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Term
What type of drug is toluene? |
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Definition
volatile intoxicant (solvent) |
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Term
What type of drug is trichloroethane? |
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Definition
volatile intoxicant (solvent) |
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Term
What type of drug is amyl nitrate? |
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Definition
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Term
What is the MOA of canabinoids? |
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Definition
CB1 receptor in the brain, CB2 receptor in the periphery |
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Term
Can you become dependent on canabinoids? |
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Definition
not physically but you can become psychologically dependent |
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Term
Can you become tolerant to canabinoids? |
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Definition
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Term
What is the canabinoid antagonist and what is it used for? |
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Definition
rimonobant; treatment for obesity but causes anhedonia as a side effect |
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Term
Can you become dpedent on CNS stimulants? |
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Definition
mild physical dependence; definite psychological dependence |
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Term
Can you become tolerant to CNS stimulants? |
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Definition
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Term
How should you treat someone who has overdosed on a stimulant? |
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Definition
maybe with an antipsychotic like haloperidol if they need it |
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Term
How do you treat someone for dependence on a CNS stimulant? |
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Definition
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Term
What is the MOA of dissociative anesthetics? |
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Definition
glutamate receptor antagonists |
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Term
Can you have dependence on a dissociative anesthetic? |
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Definition
life-threatening physical dependence as well as psychological dependence |
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Term
Do you develop tolerance to ddissociative antipsychotics? |
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Definition
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Term
How do you treat OD on dissociative anesthetics? |
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Definition
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Term
How would you treat withdrawal from a dissociative anesthetics? |
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Definition
treat seizures with benzodiazepine |
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Term
What is the MOA of hallucinogens? |
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Definition
5-HT2A receptor agonist or anticholinergic |
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Term
Can you have dependence on hallucinogens? |
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Definition
no physical dependence but definate psychological dependence |
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Term
Can you develop tolerance to hallucinogens? |
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Definition
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Term
What is the treatment for hallucinogen overdose? |
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Definition
atypical antipsychotics, preferably 5HT2A antagonists or cholinesterase inhibitor |
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Term
Can you become dependent on opioids? |
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Definition
yes both physically and psychologically; physical withdrawal symptoms= vasoconstriction, chills/goosebumps, cramping |
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Term
How is opioid dependence treated? |
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Definition
methadone maintenence (24 hour t1/2) or buprenorphine (48 hour t1/2) |
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Term
What is the MOA of sedative hypnotics? |
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Definition
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Term
Can patients become dependent on sedative hypnotics? |
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Definition
yes life threatenning physical dependence as well as psychological dependence |
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Term
Can patients become tolerant to the effects of sedative hypnotics? |
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Definition
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Term
How are sedative-hypnotic OD treated? |
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Definition
benzodiazepines like flumazenil |
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Term
How is sedative hypnotic withdrawal treated? |
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Definition
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Term
What is the antabuse used for alcoholism? |
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Definition
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