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4.13 Comprehensive Pain Managment
By Dr. Gould
102
Pharmacology
Professional
04/13/2012

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Cards

Term
What are the psychological comorbidities of pain?
Definition
anger, anxiety, loss of self esteem, sleep disturbances, depression
Term
Name some common types of neuropathic pain?
Definition
trigeminal neuralgia, postherpetic neuralgia, neuropathic low back pain, polyneuropathy (diabetic, HIV)
Term
T/F Diagnosing psychogenic pain is made solely by excluding organic causes of the pain.
Definition
false, you also need emtional conflict or psychosocial problems
Term
What are the different types of free nerve ending fiber types?
Definition
A"beta", A"delta", C-fiber
Term
How big are A"beta" fibers?
Definition
6-12um
Term
How big are A"delta" fibers?
Definition
1-6um
Term
How big are C-fibers?
Definition
<1.5um
Term
Name mediators involved in nociceptive signal initiation?
Definition
nerve growth factor, interleukins, TNF alpha, protons, PAF, PGE2, substance P, glutamine, bradykinin, histamine, serotonin, adenosine
Term
How many isoforms of the voltage gated sodium channel are there?
Definition
9
Term
The different isoforms of the voltage-gated sodium channels are distinguished by...
Definition
resistance or sensitivity to tetrodotoxin (TTX), functional characteristics, distribution, when present
Term
What are the characteristics of sodium channel 1.6?
Definition
predominant isoform in nodes of ranvier; very rapid repriming, produces both persistent, transient and resurgent sodium currents to maintain high frequency firing and rapid conduction of the action potential
Term
What are the characteristics of voltage gated channel 1.7?
Definition
rapid activation, slow inactivation and repriming; associated with early stages of action potential generation; delayed inactivation allows for summation of depolarization
Term
What are the characteristics of VG sodium channels 1.8?
Definition
found predominantly in small peripheral neurons; rapidly repriming; associated with initial stages of depolarization in action potential propagation increasing the likelihood of neuronal firing
Term
How fast are impulses transmitted down A-beta system?
Definition
70 m/sec
Term
How fast are impulses transmitted down A-delta fibers?
Definition
30 m/sec
Term
How fast do C-fibers transmit impulses?
Definition
2 m/sec
Term
Describe the neurons of the dorsal root ganglia?
Definition
pseudounipolar neurons/satellite cells
Term
Are there any synapses in the dorsal root ganglia?
Definition
no primary afferent synapses but potential from cross-excitation and ectopic firing
Term
Name 2 kinds of glutamate receptors?
Definition
AMPA and NMDA
Term
Somatic afferent neurons carrying pain sensation decussate at the _____.
Definition
ventral white commissure of the spinal cord
Term
What are the 2 discrete pathways of the anterolateral funiculus?
Definition
neospinothalamic tract and the paleospinothalamic tract
Term
Where does the neospinothalamic tract project?
Definition
direct projection to the VPN, (topography and modality)
Term
Where does the paleospinothalamic tract project to?
Definition
nucleus raphe magnus, locus ceruleus (spinoreticular tract), periacqueductal grey (spinotectal tract), and posterior and intralaminar thalamic nuclei
Term
At what physical location in the brain does nociceptive stimuli reach consciousness?
Definition
at the level of the thalamus
Term
After the nociceptive stimuli reaches the thalamus, it is projected to...
Definition
cortical projections= allow for comparison with past experience and current status for interpretation
corticofugal projection=modify perception of pain intensity and determine behavior
Term
What happens when nociceptive signals reach the periacqueductal grey?
Definition
site of endorphin/enkephalin peptide and high opioid receptor density, projections inhibit inhibition that suppress descending projections
Term
Which endocannabanoids are most studied?
Definition
anandamide and 2-AG
Term
What is the MOA of endocannabanoids such as anandamide and 2-AG?
Definition
agonists at CB1/CB2 receptors as well as TRPV1 to produce inhibition of descending control; metabolize FAAH and MGL (monoacylglycerol lipase)
Term
Where is CB1 found?
Definition
in the CNS
Term
Where is CB2 found?
Definition
DRG/immunomodulation
Term
Describe the descending pathway of the nucleus raphe magnus?
Definition
site of 5-HT production: reticulospinal projections to dorsal root entry zone
Term
Describe the descending pathway of the locus ceruleus?
Definition
site of NE production: reticulospinal projections to dorsal root entry zone
Term
What are the descending pathways amonth primary and secondary afferents and interneurons?
Definition
inhibit transmitter release from primary afferent directly and via release of dynorphin, enkephalin, glycine or GABA
Term
How does the sympathetic nervous system respond to nocious stimulation?
Definition
norepinephrine release from post-ganglionic sympathetic neurons produce vasoconstriction, decreased gastrointestinal motility and reduced firing threshold of primary afferents. Increases number, frequency and duration of discharge volleys and sensitizes second order second order afferents
Term
What happens do voltage gated sodium channels of somatic afferent neurons after axotomy?
Definition
1.8, 1.9 and delayed rectifier K+ conductance are down-regulated in DRG following axotomy, but increase distally in CCI proximal to ligation. Nav 1.3 is expressed
Term
Describe the MOA of allodynia?
Definition
loss of C-fiber input to lamina I and IIo. A"beta" afferents in lamina IIi sprout new terminals that extend into the vacated synpases in IIo and allow low threshold afferent stimulation direct access to nociceptive pathways
Term
HOw can allodynia be prevented?
Definition
addition of NGF preserves C-fiber afferents which prevents the sprouting of a"beta" fibers
Term
What mutation is responsible for a congenital insensitivity to pain?
Definition
nonsense mutations in the SCN9A gene (chromosome 2q), cause loss of function of the Nav 1.7 resulting in a congenital insensitivity to pain.
Term
What happens when there is a single mutation in the Nav 1.7 gene?
Definition
can produce hyperexcitability or hypoexcitability depending upon the cell type in which teh mutation occurs; hyper- sensotry neurons, hypo-sympathetic neurons
Term
What is the mutation that causes inherited primary familial erythromelalgia?
Definition
autosomal dominant condition caused by a mutation in teh SCN9A gene resulting in a gain of function
Term
What are the symptoms of inherited primary familial erythromelalgia?
Definition
burning dysesthesia of hands, feet, and ears is debilitating, significantly impairing quality of life
Term
How do you treat inherited primary familial erythromelalgia?
Definition
tends to be refractory to treatment although sodium channel blocking agents and prostagladin analogs have shown promise
Term
What is the mutation that causes paroxysmal extreme pain disorder?
Definition
autosomal dominant condition caused by a mutation in the SCN9A gene encoding Nav 1.7 resulting in a gain of function
Term
What are the symptoms of paroxysmal extreme pain disorder at birth?
Definition
flushing of the skin of the buttocks, posterior thigh, and feet
Term
What are the symptoms of paroxysmal extreme pain disorder in childhood?
Definition
paroxysmal burning dysesthesia of rectum with erythema of pubic region, scrotum, perineum, buttocks, posterior thigh and feet
Term
Besides the perineum, posterior thigh, rectum and feet, where else do patients with paroxysmal extreme pain disorder experience burning dysesthesia and erythema?
Definition
sclera, temporal, ocular, mandibular + rhinorrhea, salivation and lacrimation
Term
What drug has shown some benefit in treating paroxysmal extreme pain disorder?
Definition
carbamazepine
Term
T/F Patients with congenital insensitivity to pain have a normal response to non-noxious sensory stimulation with intact proprioception, vibratory sense, and tactile discrimination between sharp and dull.
Definition
true
Term
Which numbers on the pain scale are considered mild vs. moderate vs. severe?
Definition
1-3=mild; 4-6=moderate; 7-10=severe
Term
The WHO states that mild pain should be treated with...
Definition
nonopiods (NSAIDS, salicylates, acetaminophen)
Term
The WHO states that you should treat moderate pain with...
Definition
weak opiods (codeine and hydrocodone) and adjuvants
Term
How does the WHO state you should treat severe pain?
Definition
strong opiods +/- adjuvants (strong opioids= morphine, oxycodone, hydromorphone, fentanyl transdermal)
Term
What is physical dependence?
Definition
withdrawal syndrome arises if drug discontinued, dose substantially reduced or antagonist administered
Term
What is tolerance?
Definition
greater amount of drug needed to maintain therapeutic effect, or loss of effect over time
Term
What is pseudoaddiction?
Definition
behavior suggestive of addiction; caused by undertreatment of pain
Term
What is addiction?
Definition
(psychological dependence):psychiatric disorder characterized by continued compulsive use of substance despite harm
Term
What is the maximum time frame you can treat pain with ketorolac?
Definition
5 days
Term
What is the prodrug to valdecoxib?
Definition
parecoxib
Term
What is tramidol used for?
Definition
moderate pain
Term
What is the MOA of tramadol?
Definition
acts at opiate receptor and blocks reuptake of NE and serotonin
Term
What are the adverse effects of tramadol?
Definition
similar to opiates, usually milder
Term
What is tapentadol used for?
Definition
unique analgesic for moderate to severe pain
Term
What is the MOA of tapentadol?
Definition
acts at opiate receptors and blocks reuptake of norepinephrine
Term
What are the adverse effects of tapentadol?
Definition
similar to opiates, usually milder
Term
What is propoxyphene?
Definition
weak opiate preparation with poor efficacy and opiate adverse effects
Term
Which weak opiates are often used in combo with acetaminophen for synergistic effect?
Definition
codeine, hydrocodone, oxycodone
Term
What are the different preparations of morphine sulfate?
Definition
immediate release for breakthrough pain, sustained release=12 hour preparation, sustained release 24 hour preparation
Term
What is Embeda?
Definition
a sustained release morphine preparation that, when crushed/chewed/dissolved releases the mu-antagonist naltrexone, thereby blocking morphine's effect
Term
Name the strong opiates.
Definition
methadone (delayed toxicity), hydromorphone (parenteral formulation), meperidine (not preferred for chronic pain), oxymorphone (oral, rectal, and injectable forms available), levorphanol (long half-life), buprenorphine (combination with naloxone)
Term
What is "Opana"?
Definition
immediate and extended release oxymorphone that is 5-10x more potent that morphine
Term
What are the indications for "Opana"?
Definition
persistent moderate to severe pain
Term
How is Opana administered?
Definition
1 hr prior to or 2 hours after eating; can give immediate release every 6 hours or extended release twice daily
Term
What are the various ways in which fentanyl can be administered?
Definition
transdermal patches, oral "lollipop", buccal disc, buccal film
Term
Name the anticonvulsants that can be used to treat neuropathic pain?
Definition
gabapentin, oxcarbazine, topiramate, levetiracetam, zonisamide, lamotrigine, carbamazepine, phenytoin, clonazepam
Term
What is the MOA of pregabalin?
Definition
blocks alpha-2-delta voltage-gated calcium channels thereby reducing release of excitatory neurotransmitters
Term
What are the pharmocokinetics of pregabalin?
Definition
like gabapentin is not protein bound, is not subject to hepatic metabolism, is cleared unchanged by the kidney
Term
What is the t1/2 of pregabalin?
Definition
6.3 hours
Term
What are the adverse effects of pregabalin?
Definition
dizziness and somnolence
Term
What is the t1/2 of lacosamide?
Definition
13 hours
Term
What is the MOA of lacosamide?
Definition
enhances Nav slow inactivation, lower repetitive firing. May offer disease modifying benefit by binding to collapsin-response mediator protein 2 (CRMP-2) that is involved in neuronal differentiation and axonal outgrowth
Term
What are the adverse effects of lacosamide?
Definition
dizziness, diplopia, headache, and somnolence
Term
Name some tricyclic antidepressants that can be used for neuropathic pain?
Definition
amitriptyline, nortriptyline, doxepine, imipramine, desipramine
Term
Name some antidepressants that are potentially beneficial in treating neuropathic pain although there has been limited testing.
Definition
venlafaxine, trazadone, bupropion, mirtazapine
Term
Which is more effective in the management of pain, TCAs or SSRIs?
Definition
TCAs
Term
What is the MOA of duloxetine?
Definition
blocks serotonin and NE reuptake
Term
How is duloxetine metabolized?
Definition
metabolized in the liver by CYP2D6 and CYP1A2
Term
What is the half life of duloxetine?
Definition
10.3
Term
What are the adverse effects of duloxetine?
Definition
insomnia, somnolence, fatigue, dizziness, nausea, dry mouth, constipation
Term
What is the MOA of milnacipran?
Definition
selectively block 5-HT and NE reuptake
Term
What are the adverse effects of milnacipran?
Definition
insomnia, somnolence, fatigue, dry mouth, headache, nausea, dizziness
Term
What antispasmodic agents can be used for neuropathic pain?
Definition
baclofen, tizanidine
Term
What is the MOA of baclofen?
Definition
GABA(B) agonist
Term
What are the side effects of baclofen?
Definition
drowsiness, lightheadedness, dizziness
Term
What are the MOA of tizanidine?
Definition
alpha-2-agonist
Term
What are the adverse effects of tizanidine?
Definition
drowsiness, orthostatic hypotension
Term
How does mexiletine treat neuropathic pain?
Definition
sodium channel blocker
Term
How does clonidine treat neuropathic pain?
Definition
by being an alpha-2 agonist
Term
T/F Lidocaine can be used to treat neuropathic pain.
Definition
transdermal patch
Term
What is the MOA of capsaicin for treating neuropathic pain?
Definition
depletes substance P
Term
What is the MOA of delta-9-tetrahydrocannabinol/cannabidiol?
Definition
CB1 receptor agonist
Term
How is delta-9-tetrahydrocannabinol/cannabidiol administered?
Definition
sublingual/oral mucosal spray
Term
T/F Most patients become tolerant to delta-9-tetrahydrocannabinol/cannabidiol.
Definition
false; not shown to produce tolerance
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