Term
| Tumor Lysis Syndrome (TLS) |
|
Definition
| Rapid release of intracellular contents into bloodstream |
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Term
|
Definition
High-grade lymphomas
Leukemia
High leukocyte count |
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Term
|
Definition
Baseline Uric acid >7.5mg/dL
Preexisting Renal impairment
Chemosensitivity
Tumor burden large |
|
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Term
|
Definition
Burkitt's lymphoma
Lymphoblastic Lymphoma
Acute Leukemia (ALL>AML)
[WBC >50-100thous] |
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Term
|
Definition
NV
Lethargy
HYPERuricemia
HYPERphosphatemia
HTN HYPOcalcemia
HYPERkalemia |
|
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Term
|
Definition
2 days before Tx & continues 2-3 days after completion
3-5L/m^2/day Saline |
|
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Term
|
Definition
Rash
NV
Bone marrow Suppress |
|
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Term
|
Definition
Takes 14 days to have max effect
(dose 100-300mg/day) |
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Term
|
Definition
| Converts Uric acid to allantoin (allantoin 5-10x more soluble in urine) |
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Term
| Rasburicase is only FDA labeled in |
|
Definition
| Labeled only for Pediatrics |
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Term
|
Definition
NVD
Fever HA
Rash Hemolysis
Methemoglobinemia |
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|
Term
| What is Methemoglobinema? |
|
Definition
SFX of Rasburicase
-Pt turns blue
-Methemoglobin=Form of hemoglobin |
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|
Term
Rasburicase toxicity can be expected with
[Hemolytic Anemia] |
|
Definition
G6PD Genotype deficiency
(CONTRAINDICATED in these pts) |
|
|
Term
| Strongly associated with ALLOPURINOL induced severe cutaneous adverse reactions |
|
Definition
|
|
Term
|
Definition
Mild: 10.5-11.9
Mod: 12-13.9
Severe: >/=14 |
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Term
| Corrected Calcium (mg/dL) = |
|
Definition
| total Serum Ca (mg/dL) + 0.8(4-measured albumin in G/L) |
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|
Term
| Normal Serum Calcium Levels |
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Definition
|
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Term
| Medications Causing HYPERcalcemia |
|
Definition
Thiazides
lithium VitD
Anatacids Tamoxifen
Ganciclovir |
|
|
Term
|
Definition
Neuro: COnfus,letharg, seize, depress
Renal: Polyuria,polydipsia
GI:NV,anorexia
Cardiac: Shortened QT,Prolonged PR |
|
|
Term
| First Line Tx for HYPERcalcemia |
|
Definition
Bisphosphonates
Zolendronic Acid 4mg IV or Pamidronate 90mg IV |
|
|
Term
| How long to give Bisphosphonates to see if it works |
|
Definition
|
|
Term
|
Definition
HYPOcalcemia
Fatigue
Emesis Fever
Osteonecrosis of the Jaw (aftr 1 yr using) |
|
|
Term
| Osteonecrosis of the Jaw happens when? |
|
Definition
| after 1 year of constant Bisphosphonate use |
|
|
Term
Manage SPinal cord Compression with
[usually thoracic] |
|
Definition
Dexamehtasone 10-16mg IV bolus
Radiation Tx
or Surgery |
|
|
Term
| Malignant Causes of Superior Vena Cava Syndrome |
|
Definition
(~85%)
Lung Cancer
Lymphomas
Solid Tumors that metastasize to mediastinum |
|
|
Term
| NON-Malignant Causes of Superior Vena Cava Syndrome |
|
Definition
(~35%)
Thrombosis
Cystic hygroma
Substernal thyoid Goiter
TB Radiation Tx
Sarcoidosis |
|
|
Term
| S/Sx Superior Vena Cava Syndrome |
|
Definition
FACE edema
Dyspnea
Cough Orthopnea(SOB)
Arm/neck edema |
|
|
Term
| Superior Vena Cava Syndrome develops how long in most pts |
|
Definition
Develops over 2 weeks
[Tx:reduce tumor w/ radiotx/chemo] |
|
|
Term
| Dx of Superior Vena Cava Syndrome |
|
Definition
Clinical exam MAINLY***
Also Chest radiograph
Bronchoscopy |
|
|
Term
| Rasburicase Contraindicated in pt with.... |
|
Definition
G6PD Genotype deficiency
[Can cause toxicity of rasburicase causing Hemolytic anemia] |
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