Term
| # of signals required to activate Th0 cells for differentiation Th0 -> Th2 |
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Definition
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Term
| First signal for Th0 cells differentiation? Th0 -> Th2 |
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Definition
| T-cell receptor (TCR) binds [MHC II + displayed peptide] complex |
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Term
| 2nd signal for Th0 cells differentiation? Th0 -> Th2 |
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Definition
| CD28 (TH0) binds B7 (APC) |
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Term
| 3rd signal for Th0 cells differentiation? Th0 -> Th2 |
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Definition
| Cytokines (e.g., interleukin-2 [IL-2]) bind |
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Term
| Overview of the Th0 -> Th2 |
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Definition
| Activating T helper cell. The apc is the presenting the antigen. Naive Th binds MCH2 that is showing a peptide dervided from antigen using the TCR on the Th cell. Occuring at the lymph node. TCR binds MHC 2 and the peptide from antigen. On the Th cell a 2nd protein-protein intrxn of CD28 binds the B7 complex on the APC= antigen presenting cell. This causes the cells to release cytokines= a major one is IL-2. The Th cell binds the cytokine which is the signal to grow up and be a Th2 and help fight the pathogen. Th0 matures to Th2 |
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Term
| # of signals required to activate B cells for differentiation, which is? |
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Definition
| 3 memory vs plasma- antibody production |
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Term
| First signal for B cell differentiation |
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Definition
| B-cell receptor (BCR) binds antigen, B cell processes + displays |
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Term
| Second signal for B cell differentiation |
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Definition
| CD40 (B cell) binds CD154 (TH2) |
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Term
| Third signal for B cell activation |
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Definition
| Cytokines (e.g., interleukins-4,5,6) bind |
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Term
| Overview of B and T cell interaction |
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Definition
| Th cells don’t make AB, B cells need to come in. Activating B cells for differentiation = some memory cells (help next time) + some plasma cells (help asap). BCR might bind to an antigen like a pilli from a microbe. The B cell runs into the Th2 cell another protein- protein intrxn the CD40 binds to Th2 CD152. Once this occurs more cytokines are released and the B cell will bind to them= future differention of B cells to plasma and memory cells. Plasma cells make the antibodies which are related to the original microbe’s antigen. |
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Term
| 3 steps for Th1 Cellular activation: |
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Definition
T-cell receptor (TCR) binds [MHC II + displayed peptide] complex (outside of the APC)
CD28 (TH0) binds B7 (APC) =protein-protein intrxn
Cytokines (e.g., interleukin-2 [IL-2]) bind |
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Term
| What is produced in Th1 activation instead of antibodies? |
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Definition
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Term
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Definition
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Term
| cytotoxic T cell activation step 1 |
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Definition
T-cell receptor (TCR) binds [*MHC I* + displayed peptide] complex
Remember CD8 +Tc only binds MHC1 |
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Term
| cytotoxic T cell activation step 2 |
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Definition
| CD28 (naïve Tc) binds B7 (APC) |
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Term
| cytotoxic T cell activation step 3 |
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Definition
| Cytokines bind (IL-2 typically comes from Th1) |
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Term
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Definition
Cytotoxic T cells now ready to attack
If same antigen encountered on new cell’s MHC1, Tc will kill it. (leave lymph node to site of infection |
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