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305 exam4 lec. 3
Immunity
21
Biochemistry
Undergraduate 3
12/02/2013

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Term
Two divisions of Immunity:
Definition
innate and acquired
Term
Innate immunity:
Definition
Natural/ “non-adaptive” / “first line defence”
“Always the same”
Term
Acquired/Adaptive Immunity
Definition
First exposure- “slow” rxn
“Memory” results in improvement upon subsequent exposures.
Term
Why vaccinations work:
Definition
Acquired immunity- Get sick enough to get adaptive response kick in but not the innate response.
Term
Interaction between the two types of immunity:
Definition
innate and adaptive systems POSTIVE intrxns
They have to interact with each other- exist together.
Term
Innate immunity speed:
Definition
immediate
Initially present
May appear shortly (hours) after
Term
Innate immunity recognizes:
Definition
“danger”
Much more general compared to adaptive
Term
innate immunity after response-
Definition
“goes away”/normalizes
Term
Does innate immunity ever improve?
Definition
NO
Term
Innate immunity barriers:
Definition
some physical and some chemicals
Term
Acquired immunity speed:
Definition
Short term response- slow; improves the next time to much faster
Term
Acquired immunity memory speed:
Definition
Takes 1-2 weeks to build up to a memory response
Term
Acquired immunity recognizes:
Definition
Recognize “antigens”- recognized by antibody
Term
Acquired immunity barriers:
Definition
antibodies, Memory B cells, WBC
Term
Lymphatic system runs -- with --
removes-- from --
uses -- cells
Definition
parallel with blood vessels
removes wastes from tissues
WBC
Term
Lyphatic system uses a White blood cells, esp: --.
Definition
lymphocytes primarily adaptive IS
Term
What is critical for WBC to mature?
Definition
thymus
bone marrow
Term
Lymphocytes:
Definition
Travel through
Monitor waste for infection
Lymph nodes = filters +meeting places (cell to cell intrxns)
filter antigen
Term
Where do Cells of the Immune System come from?
Where do the differentiate?
Definition
Come from hematopoietic (blood) stem cells
Differentiate in bone marrow and thymus
Term
most IS cells are innate and come from --. The bridge between innate and adaptive it:
Definition
innate Myeloid stem cell . natural killer cell bridge
Term
adaptive IS cells come from --
Definition
lymphoid stem cell.
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