Term
| Pyruvate Dehydrogenase Complex rxn |
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Definition
| Pyruvate + CoA + NAD+ → Acetyl-CoA + CO2 + NADH + 2 H+ |
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Term
| Pyruvate Dehydrogenase Complex usually links - |
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Definition
| sugar breakdown to TCA cycle |
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Term
| Pyruvate Dehydrogenase Complex energy carriers |
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Definition
Reducing power: 1 NADH/pyruvate (2/glucose)
No ATP |
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Term
| pyruvate dehydrogenase useful precursor metabolite |
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Definition
| Acetyl-CoA for lipid biosynthesis |
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Term
| Under low O2, facultative anaerobes turn off PDH/PDC (why?) |
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Definition
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Term
| Tricarboxylic Acid (TCA) Cycle Only in organisms with |
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Definition
an electron transport system/chain
Aerobic and anaerobic respires
NO oblligate fermenters |
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Term
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Definition
Oxidize acetyl-CoA to 2 CO2 (2C; typically from pyruvate dehydrogenase to 2CO2 (2X1 C)
Remember TCA occurs twice per glucose |
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Term
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Definition
9 steps
Some intermediates can be precursor metabolite for aa biosynthesis-reduces energy carrier yeild
Overall(1 cycle-double for 1 glucose
Acetyl-CoA + 3 NAD+ + FAD + ADP + Pi → 2 CO2 + 3 NADH + 3 H+ + FADH2 + ATP |
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Term
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Definition
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Term
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Definition
Oxaloacetate + acetyl-CoA + H2O → citrate + CoA
4C +2C ->6C
Citrate synthase |
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Term
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Definition
Citrate → cis-aconitate + H2O
6C-> 6C
aconitase |
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Term
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Definition
Cis-aconitate + H2O → isocitrate
6C-> 6C
aconitase
Steps 2 and 3: overall isomerization by aconitase |
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Term
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Definition
Isocitrate + NAD+ → α-ketoglutarate (α-KG) + CO2 + NADH + H+
6C ->5C+1C
Isocitrate dehydrogenase
EC:1 NADH formed |
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Term
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Definition
α-KG + NAD+ + CoA → succinyl-CoA + CO2 + NADH + H+
5C -> 4C+1C
2-oxoglutarate dehydrogenase
EC: 1 NADH formed |
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Term
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Definition
Succinyl-CoA + ADP (or GDP) + Pi → succinate + ATP (or GDP) + CoA
4C-> 4C
Succinate dehydrogenase (ETC)
EC: ATP (or GDP) formed |
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Term
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Definition
Succinate + FAD → fumarate + FADH2
EC: 1 FADH2 formed –immediately consumed/recycled by ETC
Succinate dehydrogenase (ETC)
ECL 1 FADH2 formed- immediately consumed/recycled by ETc |
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Term
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Definition
Fumarate + H2O → malate
4C-> 4C
Fumarase |
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Term
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Definition
Malate + NAD+ → oxaloacetate + NADH + H+
4C-> 4C
Malate dehydrogenase
Energy carrier: 1 NADH formed |
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Term
Net of:
-Entner-Doudoroff
-Pentose Phosphate
-Glycolysis
Pyruvate dehydrogenase
-TCA cycle |
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Definition
Entner-Doudoroff
1 ATP 1 NADH 1 NADPH
Pentose Phosphate
2 nADPH, 2 majr precursor metabolites (ribose-5-phosphate and erythrose-4-phosphate)
Glycolysis
2 ATP, 2 NADH
Pyruvate dehydrogenase
2 NADH per glucose, 1 precursor metabolite
TCA Cycle
2 ATP, 6 NADH, 2 FADH2 per glucose |
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