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Types of Learning & Memory |
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1. conditioning -classic & operant 2. spatial -working &reference 3. declarative (explicit) -semantic & episodic 4. procedural |
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-bilateral medial temporal lobectomy (hippocampus, amygdala, adjacent cortex) -no STM -total anterograde amnesia, mild retrograde amnesia, global amnesia -procedural memory intact -explicit (declarative) memory GONE |
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=amnesia for information presented in all sensory modalities |
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-Medial temporal lobe amnesia -caused by cerebral ischemia during surgery |
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-SPATIAL memory -location of place cells ex. morris water maze ex2. radial arm maze ex3. food caching birds have larger hippocampus |
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=memory needed to complete the task on which the subject is currently working |
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=memory of general principles & skills required to perform a task -RULES |
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OBJECT RECOGNITION memory ex. delayed non-matching to sample test with monkeys ex2. MUMBY box |
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-SENSORY MOTOR memories ex. eye blink reflex |
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-RESPONSE learning ex. T-maze |
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=memory for experiences with EMOTIONAL significance |
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prefrontal cortex & memory |
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=EPISODIC MEMORY -temporal order of events -deficits in working memory ex. can't cook |
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1. Circadian Rhythm (24 hrs) 2. Ultradian Rhythm (<24 hrs, 1-12 hrs) 3. Infradian Rhythm (>24 hrs & <1 yr) 4. Circannual Rhythm (about 1 yr) |
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=time giver ex. light-dark cycle, sun, etc |
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Most humans have a natural BR of ___ hrs |
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-biological clock, SCN (suprachlasmatic nucleus) -entrained by zeitgeber |
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=still display activity but NO RHYTHM |
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RHT (and previous tracts) & SCN intact |
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optic nerve & optic tract |
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1. beta (awake, sm amplitude) 2. alpha (awake but resting, larger amp) 3. delta (sleeping, largest amp) |
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anterior hypothalamus (promote sleep) posterior hypothalamus (promote wakefulness) |
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Neural control of arousal & wakefulness |
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reticular formation reticular activating system (RAS) |
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Neural control of REM sleep |
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caudal reticular formation |
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1. termination insomnia 2. onset insomnia 3. maintenance insomnia |
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in narcolepsy =loss of muscle activity or tone while awake & conscious -most common |
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in narc =inability to move when waking up or falling asleep |
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1. steroid hormones 2. peptide hormones 3. amino acid derivatives |
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-strings of aa -bind to membrane-bound receptors bc they cant make it into cell on their own) -cAMP (2nd messenger) activates enzymes in cytoplasm that cause alteration -top endocrine glands |
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-moves into NUCLEUS -cholesterol based, 4 ring structure 1. androgens (=male like) -made in gonads ex. testosterone (t), dihydrotestosterone (DHT) (via reductase) 2. estrogens -made in gonads/ovaries ex. Estrodiol (E2) 3. Progestins -made in ovaries, acts on uterus ex. progesterone (P) 4. Glucocorticoids -made in adrenal cortex ex. cortisol (humans) & corticosterone (rats) |
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Posterior Pituitary Hormones |
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-made in HYPOTHALAMUS -extension of axons from PVN & SON -PEPTIDES 1. oxytocin 2. vassopressin aka ADH |
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Post. Pit. Hormone made in hypothalamus associated with love/trust/breastfeeding |
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Post. Pit. Hormone peptide AKA ADH (anti-diuretic hormone) -increase bl pressure, absorbs fluid -alcohol inhibits ADH |
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2nd messengers are found? |
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in the cytoplasm of the neuron |
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HYPOTHALAMUS (not pituitary which is controlled by the hypothalamus) |
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-hormones made in the anterior pituitary -RH travels down blood portal, binds to receptor, releases corresponding hormone |
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=targets gonads ex. LH (leteinizing hormone) & FSH (follicle stimulating hormone) -same RH works on both (GnRH/LHRH) -negative feedback: E2 & P |
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Once a month, ___ is released to mature and egg to be released by ___. |
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FSH= sperm LH= Testosterone |
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(adrenocortiotrophi hormone) -made in anterior pituitary -peptide -released by: CRH (corticotrophin) or ACTH-RH -target: adrenal cortex to release cortisol -neg. feedback: cortisol goes to hypothalamus & inhibits CRH production |
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in adrenal cortex produces EPINEPHRINE |
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Peptide ant pit hormone hypothalamus release Prolactin RH target: breast tissue, produces milk (oxytocin pushed milk out) inhibited by: dopamine |
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-metabolism -TRH in Hypothalamus -TSH in Pituitary (thyrotropin) -target: thyroid gland to release T3 & T4 |
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GHRH in Hypothalamus GH in ant. pit. target: Lots neg. feedback: GHR-IH aka somatostatin |
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=normal size, but growing in random places |
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=testicular feminization -lacking ANDROGEN RECEPTORS -Testes but NO int or ext male structures -At puberty, NO PERIODS |
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Congenital Andrenal Hyperplasia (CAH) |
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=problems with ADRENAL GLANDS too much T, not enough cortisol -int female structures -extra T--> small penis on clitoris -tomboys |
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NO REDUCTASE, so no DHT -int male structures -NO ext male structures - at puberty, extra T--> ext male structures develop |
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XO -only 1 sex chromosome -45 chromosomes -webbing on neck -short -no breasts |
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XXY -tall, long limbs -not much pubic hair -lower IQ -mostly male |
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Males: larger Females: smaller
but similar at prenatal, females decrease from lack of T |
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VMH-->PAG--> SC--> muscles -abolished by: VMHX, PAGX -increased by: VMH stimulation or injections of E2 & P to VMH |
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sexual motivation in males |
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sexual behavior in males (mounting) |
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MPOA (medial preoptic area) |
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