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201 MOD A B D
Chemo, Patient Care
219
Nursing
Undergraduate 2
08/28/2012

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Term
Malignant Cell Growth
Definition
Cancer
Term
Mitosis
Definition
cell division
Term
Hypertrophy
Definition
Growth that causes tissue to increase in size by enlarging each cell
Term
Hyperplasia
Definition
Growth that causes tissue to increase in size by increasing the number of cells
Term
Neoplasia
Definition
Any new or continued cell growth not needed for normal development or replacement of dead or damaged tissues
*always abnormal even though it causes no harm
*develop from normal cells (parent cells)
Term
Cells undergo mitosis to (2 reasons)
Definition
develop normal tissue
replace lost or damaged normal tissue
Term
Apoptosis
Definition
programmed cell death
Term
Features of a normal Cell
Definition
Limited Cell Division, Apoptosis, Small nuclear to cytoplasmic ratio, Differentiated Function, Tight Adherence, Non Migratory, Orderly and Well Regulated Growth
Term
Cyclins
Definition
Proteins that promote cells to enter and complete cell division.
Term
Euploidy
Definition
Normal 23 pairs of chromosomes
Term
Benign Cells
Definition
normal cells growing in wrong place or at the wrong time
Term
Benign Tumor Characteristics
Definition
Continuous or Inappropriate Cell Growth, Specific morphology, tight adherence, No migration, Orderly growth, Normal chromosomes (23 pair)
Term
Cancer Cell Characteristics
Definition
Rapid or continuous cell division, Anaplasia, A large nuclear-cytoplasmic ratio, Specific functions are lost, Loose adherence, Migration, Contact inhibition does not occur, Abnormal chromosomes (aneuploidy)
Term
Names for Cancers
Definition
Carcinogenesis
Oncogenesis
Term
Malignant Transformation
Definition
process of changing a normal cell into cancer cell
Term
Steps of Malignant Transformation
Definition
Initiation - oncogenes turne on excessively (overexpressed)
Promotion - develop its own blood supply
Progression - continued change of cancer
Metastasis
Term
Carcinogens
Definition
substances that change the activity of a cells gene so it becomes cancerous. Can be chemical, physical agents or viruses
Term
Promoters
Definition
substances that promote/enhance growth of the initiated cancer cell
Insulin and Estrogen Promote Cancer
Term
Latency Period
Definition
time between cells initiation and the development of an overt tumor
Term
A detectable tumor is
Definition
About 1 cm and has at least a billion cells in it.
Term
A tumor grows & survives by
Definition
making its own blood supply, by makes tumor angiogenesis factor (TAF) that triggers capillaries & other bv in area to grow new branches
Term
Primary Tumor
Definition
original tumor usually identified by tissue came from
Term
Metastasis occurs
Definition
when cancer cells move from the primary location by breaking off from the original group & establishing remote colonies. Additional tumors called metastatic or secondary tumors
Term
Epithelial Gland
Definition
Adenoma/Adenocarcinoma
Term
Cartilage (Tumor & Cancer)
Definition
Chondroma/Chondrosarcoma
Term
Fibrous connective
Definition
Fibroma/Fibrosarcoma
Term
Glial Cells (brain)
Definition
Gloma/Glioblastoma
Term
Blood vessel
Definition
Hemangloma/Hemangiosarcoma
Term
Liver
Definition
Hepatoma/Hepatocarcinoma or Hepatoblastoma
Term
Smooth Muscle
Definition
Leiomyoma/Leiomyosarcoma
Term
Fat/Adipose
Definition
Lipoma/Liposarcoma
Term
Lymphoid tissue
Malignant Lymphomas
Definition
Hodgkin's Lymphoma
Non-Hodgkins Lymphoma
Burkitts Lymphoma
Cutaneous T-Cell
Term
Pigment producing skin
Definition
Melanoma
Term
Meninges
Definition
Meningioma
Malignant Meningioma or Meningiblastoma
Term
Nerve Tissue
Definition
Neuroma or Neurofibroma (benign)
Neurosarcoma or Neuroblastoma
Term
Bone
Definition
Osteoma
Osteosarcoma
Term
Kidney
Definition
Renal Cell Carcinoma
Term
Skeletal Muscle
Definition
Rhabdomyoma
Rhabdomyosarcoma
Term
Blood vessel
Definition
Hemangloma/Hemangiosarcoma
Term
Liver
Definition
Hepatoma/Hepatocarcinoma or Hepatoblastoma
Term
Smooth Muscle
Definition
Leiomyoma/Leiomyosarcoma
Term
Fat/Adipose
Definition
Lipoma/Liposarcoma
Term
Lymphoid tissue
Malignant Lymphomas
Definition
Hodgkin's Lymphoma
Non-Hodgkins Lymphoma
Burkitts Lymphoma
Cutaneous T-Cell
Term
Pigment producing skin
Definition
Melanoma
Term
Meninges
Definition
Meningioma
Malignant Meningioma or Meningiblastoma
Term
Nerve Tissue
Definition
Neuroma or Neurofibroma (benign)
Neurosarcoma or Neuroblastoma
Term
Bone
Definition
Osteoma
Osteosarcoma
Term
Kidney
Definition
Renal Cell Carcinoma
Term
Skeletal Muscle
Definition
Rhabdomyoma
Rhabdomyosarcoma
Term
Epithelial layer of skin, mucous membranes and organ linings
Definition
Papilloma
Squamous cell carcinoma of skin, bladder, lungs and cervix
Term
Common sites of Metastasis of Breast Cancer
Definition
Bone, Lung, Liver, Brain
Term
Common sites of Metastasis of Lung Cancer
Definition
Brain, bone, liver, lymph nodes, pancreas
Term
Common Sites of Metastasis of Colorectal Cancer
Definition
Liver, Lymph Nodes, Adjacent Structures
Term
Grading of Tumor
Definition
cellular aspects
how it looks
Term
Ploidying of a Tumor
Definition
Cellular Aspects
Term
Staging
Definition
clinical aspects of cancer. What it is doing
Determines the exact location of the cancer & its degree of metastasis at diagnosis.
Term
Gx
Definition
Grade cannot be determined
Term
G1
Definition
well differentiated and closely resemble normal cells
low grade of malignant change
malignant but slow growing
Term
G2
Definition
moderately differentiated
retain some characteristics of normal cells but more malignant than G2
Term
G3
Definition
poorly differentiated, retain no normal cell characteristics
Term
G4
Definition
poorly differentiated, no normal cell characteristics
Determination of tissue of origin is difficult & perhaps impossible
Term
Tx
Definition
Primary tumor cannot be assessed
Term
T0
Definition
No evidence of primary tumor
Term
Tis
Definition
Carcinoma in situ
Term
T1, T2, T3, T4
Definition
increasing size and/or local extent of the primary tumor
Term
Nx
Definition
Regional Lymph Nodes cannot be assessed
Term
N0
Definition
no regional lymph nodes metastasis
Term
N1, N2, N3
Definition
increasing involvement of regional lymph nodes
Term
Distant Metastasis
Mx
M0
M1
Definition
Mx - presence of distant metastasis cannot be assessed
M0 - No distant Metastasis
M1 - Distant Metastasis
Term
Aneuploidy
Definition
gain or lose whole chromosomes & have structural abnormalities of remaining chromosomes
Term
Pathologic Staging
Definition
determining tumor size, number, sites and spread by pathologic exam of tissues obtained at surgery
Term
TNM
Definition
Tumor, Node, Metastasis. Describes anatomic extent of cancer.
American Joint Committee on Cancer developed.
Term
Doubling Time
Definition
the amt of time to double in size
Term
Mitotic Index
Definition
percentage of actively dividing cells within a tumor
1 cm tumor has to undergo about 30 doubling times to reach about a billion cells. Mitotic Index of Less than 10% is slow. 85% is fast.
Term
Factors that influence cancer development
Definition
exposure to carcinogens, genetic predisposition, and immune function
Term
2 physical carcinogenesis
Definition
radiation and chronic irritation
Term
Viruses associated with Cancers
Definition
Epstein Bar - Burkitts Lymphoma, B-Cell Lymphoma, Napsopharyngeal carcinoma
Hep B - liver
Hep C - liver, B Cell lymphoma
HPV - cervical, vulvar, other genital carcinomas
Term
7 warning signs of cancer
Definition
C - Changes in bowel or bladder habits
A - A sore that does not heal
U - Unusual Bleeding
T - Thickening or lump in breast/elsewhere
I - Indigestion or difficulty swallowing
O - Obvious change in wart or mole
N - Nagging cough or hoarseness
Term
Nursing Assessments for Colorectal Cancer
Definition
changes in bowel habits, blood in stool - test one stool for elder pt in hospital, encourage baseline colonoscopy, reduce fat, red meat and smoked meats, increase fiber, bran, veg & fruit
Term
Nursing Assessments for Bladder Cancer
Definition
pain on urination, blood in urine, cloudy urine, increase frequency or urgency
Term
Nursing Assessment for Prostate Cancer
Definition
Hesitancy, change in size of urine stream, pain in back or legs, hx of urinary tract infx
Term
Nursing Assessment for Skin Cancer
Definition
examine & changes in skin, moles, warts
Term
Nursing Assessment for Leukemia
Definition
Fatigue, Bruising, Bleeding tendency, hx of infection/illnesses, night sweats, unexplained fever
Term
Nursing Assessment for Lung Cancer
Definition
Cough, hoarseness, smoking hx, exposure to inhalation irritants, SOB, Activity intolerance, frothy/bloody sputum, pain in arms/chest, difficulty swallowing
Term
What drugs reduce risk of colon cancer
Definition
aspirin & celecoxib (Celebrex)
Term
What reduces the risk for Breast Cancer
Definition
Vitamin D & tamoxifen
Term
What reduces the risk of prostate cancer
Definition
lycopene
Term
A vaccination that is a primary cancer prevention is
Definition
Gardasil prevents the HPV virus
Term
Cachexia
Definition
Extreme body wasting & malnutrition
Term
General disease related consequences of cancer are
Definition
reduced immunity & blood producing functions, altered GI structures & function, motor sensory deficits, decreased respiratory function
Term
Prophylactic Surgery
Definition
removal of at risk tissue to prevent cancer development
Term
Exposure
Definition
amount of radiation delivered to tissue
Term
Radiation Dose
Definition
amount absorbed by tissue
Term
Teletherapy
Definition
distant treatment, radiation source is external to the patient, ***patient is not radioactive and is not a hazard to others
Term
Brachytherapy
Definition
short or close therapy. the radiation source comes into direct, continuous contact with the tumor tissues for a specific period of time. **The source is within the patient emits radiation for a period of time and is a hazard to others
Term
When radioactive isotopes are given as Brachytherapy, what is the precaution
Definition
body wastes, and should not be directly touched by other people. Once the isotope is eliminated, neither the pt nor wastes are radioactive, most isotopes are eliminated within 48 hrs
Term
Solid or sealed radiation sources are
Definition
implanted within or near tumor, can be temp or permanent, the patient emits radiation while in place but excreta are not radioactive ***does not impose a hazard
Term
Side effects to radiation
Definition
skin changes, local hair loss (likely permanent), altered taste sensation, (some report aversion to red meat), fatigue (debilitating /can last for wks to months), tissue fibrosis & scarring
Term
Women who receive HDR therapy for uterine cancer may develop radiation induced changes in
Definition
colon years later resulting in constipation & obstruction
Term
Radiation nursing care
Definition
becomes dry & may break down - THIS IS PRIORITY NURSING INTERVENTION
No lotions/ointments unless Rx
no direct skin exposure to sun during treatment & for 1 year
Term
Skin Education for Radiation Tx
Definition
wash area gently daily w/water/mild soap, use hand no clothe, rinse thoroughly, DONT REMOVE INK MARKINGS, dry by patting, no powders/ointments/lotions or creams unless Rx, wear soft clothing, avoid restrictive clothing/belts/buckles/straps/bindings, avoid sun, protect with clothing BUT NOT SUNSCREEN, outdoors early in mornings & late evenings, stay in shade, avoid heat exposure
Term
chemotherapy
Definition
treatment with chemicals. has some selectivity for killing cancer over normal cells. it is most effective with rapid growth cancer
Term
Adjuvant Therapy
Definition
Chemo used along with surgery or radiation
Term
cytotoxic
Definition
cell damaging
Term
Normal Cells most affected by chemo are
Definition
those that divide rapidly skin, hair, nails, intestinal tissues, spermatocytes, and bloodforming cells
Term
Nursing Care for Patients with Sealed Implants or Radioactive Sources -
Definition
private room/bath, "Caution: Radioactive Material" on door, portable lead shields (if used) placed between pt and door, door to room closed, dosimeter film badge at all times, lead apron when providing care keeping front of apron facing source, no pregnant nurses/visitors, limit each visitor to 1/2 hour per day & they stay 6 ft from pt, no one under 16, never touch source with bare hands, if dislodged pick up with forceps and put in lead container that is in room, save all dressing & linens until after source is removed and then dispose of normally
Term
Antimetabolites
Definition
closely resemble metabolites impairs cell division
Term
Antitumor antibiotics
Definition
damages cells DNA & interrupt DNA/RNA synthesis
Term
Antimitotic Agents
Definition
interfere with formation of microtubules so can't complete mitosis during division
Term
Alkylating agents
Definition
cross link DNA making the 2 DNA strands bind closely prevents proper DNA/RNA synthesis
Term
Topoisomerase Inhibitors
Definition
disruptics an enzyme that is needed to copy DNA
Term
Nadir
Definition
time when bone marrow activity & abc counts are at their lowest levels after chemo
Term
A major complication of IV infusion
Definition
extravasation - movement of the IV needle so the drug leaks into surrounding tissues a/k/a infiltration
Term
vesicants
Definition
chemicals that damager tissue on direct contact
Term
Most important nursing intervention for infiltration
Definition
PREVENTION. (small 0.5ml resolve without treatment). if larger surgical intervention may be needed. CLOSE MONITORING, Antidotes or chemoprotective agents may be injected to the site
Term
Nursing Interventions for Infiltration
Definition
document date/time when identified/suspected, when infusion was started, exact contents of infusion fluid & volume of fluid infused, diagram the exact insertion site & indicate if venous access device/implanted port/tunneled cath, method of adminstration, needle type/size, indicate on diagram location & # needle attempts, record time between extravasation & last documented full blood return, ID all agents administered in last 24 hrs (listing agent administered, dosage & volume, & order of administration), take/record vitals, ask/record subjective sensations/symptoms, record observation of site (size, color, texture), photo site, document administration of neutralizing or antidote agents, document application of compresses & their temperature, doc nursing interventions, record pt's responses, document dr. notification (including time), document written/oral instructions given to pt about follow up care, document any consultation request, sign the document
Term
anemia
Definition
decreased rbc and hemoglobin
Term
NEUTROPENIA
Definition
decreased WBC leading to immunosuppression
Term
THROMBOCYTOPENIA
Definition
Decreased number of platelets
Term
ALOPECIA
Definition
hair loss
Term
Mucositis
Definition
open sores on mucous membranes
Term
Priority Nursing Care for Chemotherapy
Definition
protecting the pt from the life threatening side effects & managing the distressing symptoms
Term
Side Effects of Chemotherapy
Definition
Bone Marrow Suppression, N & V, Mucositis, Alopecia, Changes in Cognitive Function, Peripheral Neuropathy
Term
Neutropenia Risks
Definition
Infection, extreme risk for sepsis. most infx result from overgrowth of pt's norma flora. infx risk can be managed with use of biological response modifiers (BRMs) to stimulate bone marrow production. not covered by insurance.
Term
Neutropenia Nursing Interventions
Definition
protect from infxs, teach how to reduce risk, total pt assessment (skin & mucous membranes, lung, mouth assess, venous access device performed q8hrs by RN, aseptic technique, private room, clean rooms once a day, no use of public supplies, limit health care entering, vitals q4hrs, inspect mouth q8hrs & skin mucous membranes, IV & open areas inspect q4hrs, change wound dressing daily, culture any suspected area, assist pt in cough/deep breathing, change IV tubing daily, keep b/p stethoscope & thermometer in room, limit visitors to healthy adults, aseptic tech on invasive procedures, monitor WBC daily (especially ANC absolute neutrophil count), avoid use of indwelling catheters, no plants fruits vegetables undercooked meats, etc no use of pepper/paprika as seasoning on food
Term
If Neutropenia patient is tired and doesn't want personal hygiene what does nurse do
Definition
certain aspects of personal hygiene cannot be deferred, stress the importance & Importance of mouth care and washing of the axillary & perianal regions q12hrs
Term
Any elevation in temperature in Neutropenia pt
Definition
is significant & considered sign of infection & should be reported to dr immediately usually you would order a culture immediately
Term
Thrombocytopenia risk
Definition
excessive bleeding. when platelet count is less than 50,000 mm3, Pts with fewer than 20,000 platelets/mm3 may have spontaneous & uncontrolled bleeding requiring transfusion therapy
Term
ESA
Definition
Erythropoiesis-stimulating agents (example - Aranesp, Epogen, Procrit) = increases risk for HTN, clots, strokes, & MI especially older, MONITOR HEMOGLOBIN LEVELS
Term
Neumega (oprelvekin)
Definition
BRM therapy for thrombocytopenia. increases production of platelets, SE - fluid retention, increases risk for CHF & PE, conjunctival bleeding, Hypotension, tachycardia. TEACH TO WEIGH DAILY, KEEP RECORD OF WT, REPORT ANY DYSPNEA IMMEDIATELY
Term
Prevention care for Thrombocytopenia
Definition
gentle handling, lift sheet, avoid IM & venipunctures (when necessary use smallest gauge needle & apply firm pressure to stick area for 10 minutes - or til no longer oozing blood), apply ice to trauma areas, test all urine & stool for blood, observe IV site q4hrs, no enemas, no rectal temps, if suppositories Rx lubricate liberally, measure abdominal girth daily, no razors, soft bristol toothbrush no floss, no water pressure cleaners, make certain dentures fit - don't rub, no blow nose, instruct UAP & pt to wear firm soles when ambulating, keep pathways clear
Term
Emetogenic
Definition
vomiting inducing
Term
cisplatin
Definition
chemo drug
induces vomiting 5 to 7 days later
Term
Mucositis practice
Definition
examine mouth/under tongue/roof/between cheeks & teeth q4hrs, document location/size/character of fissures/blisters/sores/drainage, get an order to obtain specimens of sores/drainage, brush teeth/tongue with soft bristled brush or sponge q8hrs, rinse with 1/2 peroxide & 1/2 NS q12hrs, avoid alcohol or glycerin based mouthwashes, encourage 3 liters of water per day, administer antimicrobial drugs as Rx, administer topical analgesic drugs as Rx, swish and spit room temp tap water or NS as needed, apply petroleum jelly to pts lips after each mouth care, assist pt using artificial saliva as needed if Rx, no tobacco/alcohol, avoid spicy/salty/acidic beverages, cool liquids, use dentures only during meals, soak dentures in microbial solution and rinse thoroughly before using, complete mouth care before/after meals, clean toothbrush daily,
Term
Alopecia
Nursing Care
Definition
hair loss with chemo, hair starts to grow 1 mo after chemo,
teach to prevent injury to scalp & cope with body image, sunscreen on head or coverings, suggest purchase of wig before therapy starts
Term
Chemobrain
Definition
term used by breast cancer its for loss of cognitive function, priority nursing intervention is to support pt
Term
Peripheral Neuropathy
Definition
PN - loss of sensory or motor function of peripheral nerves, often rapid onset, orthostatic hypotension, efrectile dysfunction, neuropathic pain, loss of taste, discrimination & severe constipation, PRIORITY NURSING CARE IS TO PREVENT INJURY TEACHING, risk for falls,
Term
teaching priorities for pts with chemotherapy induced peripheral neuropathy
Definition
protect feet/other body areas - no bare feet/stocking - always wear shoes long enough & wide to prevent sores/blisters, long break in periods for new shoes (not longer than 2 hrs), avoid pointed toe shoes/high heels, inspect feet daily with mirror for open sores/redness, avoid extreme temps, test water with thermometer, use potholders
Term
anastrozole (Arimidex)
Definition
aromatase inhibitor prevents production of Estrogen in adrenal glands & reduces blood levels of estrogens
Term
Side effects of Adrogens & the antiestrogen receptor drugs
Definition
masculinizing effects in women, fluid retention, acne, hypercalcemia, liver dysfunction
Term
Estrogen & Progestins SE
Definition
Women - irregular/heavy period, fluid retention, breast tenderness, INCREASED RISK FOR THROMBOSIS for men & women
Term
Photodynamic Therapy Education
Definition
bring protective clothing & UV sunglasses when you come to be injected, have someone else drive while Pt places light sheet over them, no light for 1 to 3 mo, cover all windows, replace high watt bulbs, effects last from 1 to 3 mo, drink plenty of water, no new Rx/OTC drugs, re-exposure 1 inch at at time with 10 minutes & increase time by 5 minutes, sunscreen will no prevent severe sunburn during this time, notify photodynamic therapy healthcare team if pain/blistering, continue dark glasses until no pain, see ophthalmologist with no longer sensitive to check retina damage TEACH PT BEFORE THEY COME FOR INJECTION!!!
Term
BRMs (Biological Response Modifiers)
Definition
modify pts responses to tumor cells.
Term
cytokines
Definition
BRMs made by macrophages, neutrophils, eosinophils & monocytes are monotones; produced by lymphocyte, make the immune system stronger
Term
How do BRMs & Cytokines work as cancer treatment
Definition
by stimulating the immune system to recognize cancer cells & take action to eliminate them.
Term
2 types of BRMs
Definition
Interleukins & Interferons
Term
Interleukins
Definition
help regulate inflammation & immune protection
Term
Interferons
Definition
cell produced proteins that can protect noninfected cells from viral infections & replication slows tumor cell division, stimuate the growth & activation of NK cells, help cancer cell resume a more normal appearance & function, inhibit the expression of oncogenes. Effective in melanoma, hairy cell leukemia, renal cell carcinoma, ovarian cancer & cutaneous T cell lymphoma
Term
BRMs Side Effects
Definition
inflammatory Reactions, fluid shifts & capillary leak with edema, patients receiving high doses should be in ICU, effects resolve when complete treatment, fever chills rigor DEMEROL IS TREATMENT FOR SEVERE RIGORs - severe shaking chills,
Term
Interferon SE
Definition
peripheral neuropathy - decreased sensory perception, visual disturbances, decreased hearing, unsteady balance & gait & OH, skin rashes, dryness, itching peeling
Term
trastuzumab (Herceptin)
Definition
targeted therapy
Term
Side Effects of Targeted Therapy
Definition
allergic reactions
Term
Sepsis or septicemia
Definition
organism enters bloodstream can result in septic shock
SE - DIC - disseminated IV coagulation - most often in leukemia & adenocarcinomas of lung, pancreas, stomach & prostate - extensive small bloodvessel clotting of factors & platelets - PREVENTION IS BEST PLAN OF CARE - practice aseptic technique, teach early S & S, IV antibiotics, anticoagulants (heparin) & cryoprecipitated clotting factors when DIC has progressed & hemorrhage is primary problem
Term
SIADH - Inappropriate Antidiuretic Hormone
Definition
side effect of cancer usually in lung/brain cancers. Tumors secrete ADH (or be a side effect of morphine sulfate, cyclophosphamide), water is reabsorbed to excess by kidney put in circulation, SE - hyponatremia - low sodium levels (115 to 120 - normal is 135 to 145) weight gain, nervous system changes, personality changes, confusion, extreme muscle weakness
TREATMENT - managing & treat cause, restore normal fluid balance, provide supportive care, restrict fluids to 1 Lday increase sodium intake, and drug therapy - demeclocycline - antibiotic works in opposition of ADH, prevent fluid fluid overload that would result in PE & heart failure, monitor for increased fluid overload q2hrs
Term
normal sodium levels
Definition
135 to 145
Term
Indicators of Increased fluid overload
Definition
increase pulse quality, increased neck vein distention, crackles in lungs, peripheral edema, reduced urine output
Term
Spinal Cord Compression
Definition
Assess neuro changes - S & S are back pain, muscle weakness, sensation of heaviness in arms/legs, numbness/tingling in hands or feet, loss of hot/cold sensation, unsteady gait, constipation, incontenience, difficulty start/stop urine. TEACH manifestation, seek help, MRI usually ordered, treatment often palliative, high dose corticosteroids to reduce swelling & relieve symptoms, high dose radiation may be given to reduce tumor
Term
Hypercalcemia
Definition
occurs mostly with bone metastasis
S & S early - fatigue, loss of appetite, N & V, constipation, polyuria. Other S & S - severe muscle weakness, loss of DTR, paralytic ileus, dehydration, ECG changes. TREATMENT - oral hydration of NS, drugs oral glucocorticoids, calcitonin, diphosphonate, gallium nitrate & mithramycin lower serum calcium. Also dia;usos
Term
Superior Vena Cava Syndrome
Definition
SVC is compressed or obstructed by rumor. (lymphomas & lung cancer). blocks venous flow to head, neck & upper trunk, edema in face (especially around eyes), tighteness of shirt collar (STOKE'S SIGN), S & S gets worse - edema in hads & arms, dyspnea, erythema of upper body & epistaxis. Late manifestations are hemorrhage, cyanosis, mental status changes from lack of blood to brain, decreased cardiac output, hypoTN. Treatment - high dose radiation to mediastinal area for temp relief, stent in VC, angioplasty
Term
TUMOR LYSIS SYNDROME
Definition
large # of tumors destroyed rapidly. (TLS IS a positive sign that cancer treatment is effective). can cause severe tissue damage/death. Increased Potassium causes cardiac dysfunction, large amts of purines cause hyperuricemia, sludge in kidneys -blocking causes renal failure (most often seen in leukemias, lymphomas, small cell lung, multiple myeloma. TREATMENT - Hydration, drink 3 to 5 L of water a day on day before, of, and for 3 days after treatment, some fluids should be alkaline (sodium bicarbonate) to prevent uric acid precipitation, keep fluid consistant throughout 24 hours a day, draw up a schedule for fluid intake, antiemetic regimen for N&V, give drugs that reduce the excretion of purines,
Term
Drugs that increase the excretion of purines
Definition
allopurinol (Aloprim, Zyloprim) or rasburicase (Elitek)
Term
sodium polystyrene sulfonate can be given orally or as a retention enema to
Definition
reduce serum potassium levels for mild to moderate hyperkalemia
Term
Severe Hyperkalemia should be treated by
Definition
IV of glucose & insulin
Term
Severe Hyperkalemia & Hyperuricemia can be treated by
Definition
Dialysis
Term
Como chemo N&V drug given before therapy
Definition
ondansetron (Zofran) - blocks 5-HT3 receptors in brain (chemotrigger zone) & in intestines, prevents serotonin from binding to receptors & activating N & V center
Term
Acute & Delayed N & V for Chemo
Definition
ondansetron (Zofran), aprepitant (Emend) and dexamethasone (Decadron) = blocks substand P neurokinin receptor. serotonin antagonist & corticosteroid
Term
If receiving chemo taking anti nausea what meds are impacted
Definition
warfarin (Coumadin) needs INRs checked (needs to be increased) before and after the 3 days of therapy. Use additional forms of birth control
Term
Neutropenia risk
Definition
life threatening sepsis & septic shock, immunosuppressed, first nursing intervention should be to do blood & urine cultures
Term
Neumega (oprelvekin) risk
Definition
pulmonary edema (assess respiratory rate), breath sounds and oxygen saturation and then notify dr., it is used to treat thrombocytopenia - low platelet count
Term
Administration of chemotherapy by the nurse requires
Definition
double gloves (required by OSHA) & Oncology Nursing Society
Term
BRMs stimulate
Definition
the immune system
Term
A cancer pt oncologic emergency
Definition
low WBC - risk for sepsis, nonintact skin of the neutropenic client, tumor lysis syndrome - can cause K+ to increase & large amts of purines in the liver converted to uric acid in blood leading to acute renal failure
Term
Oncologic Emergency that requires client to call dr immediately
Definition
edema in arms & hands - indicates compression of SVC - Superior Vena Cava Syndrome
Term
Pain in back of legs indicator of what cancer
Definition
prostate in older man
Term
Genetic testing requires
Definition
3 generation pedigree
Term
Single most important risk factor for Cancer is
Definition
Advancing Age, resulting in immune protection decreasing
Term
What allows oncogenes to be overexpressed
Definition
initiation by carcinogens damages the DNA of a cell. Oncogenes are overexpressed when initiated
Term
Insulin & Estrogen enghance the division of an initated cell during the
Definition
Promotional Phase
Term
Progression phase is
Definition
when the blood supply changes from diffusion to TAF
Term
Lung cancer tends to metastasis to
Definition
brain, lymph nodes, liver, bone
Term
Altered oncogenes are passed on
Definition
from one generation to another which increases the risk of cancer development.
Term
Patient education is the responsibility of
Definition
the nurse (via all state nurse practice acts)
Term
Learning
Definition
purposeful acquisition of a new knowledge, attitude, behavior or skill
Term
learning objective
Definition
describes what the patient will be able to do after successful instruction
Term
Referent
Definition
idea that initiates reason for communication
Term
Sender
Definition
person conveys message to another
Term
INTRAPERSONAL VARIABLES
Definition
Knowledge, values, emotions & sociocultural influences that affect sender's thoughts
Term
Cognitive Learning
Definition
what the patient actually knows and understands. Including intellectual behaviors. Includes: Acquisition of knowledge; comprehension; application; analysis; synthesis; evaluation
Term
Affective learning
Definition
includes pt's feelings, attitudes, opinions, and values. (determined by patients education)
Term
Psychomotor learning
Definition
occurs when patient acquire skills that require the integration of knowledge & physical skills
Term
Motivation
Definition
internal impulse that causes the person to take action & addresses the person's desire to learn
Term
attentional set
Definition
mental state that allows the learner to focus on and understand the material
Term
Basic Learning Principles
Definition
motivation to learn; ability to learn; learning environment;
Term
Ability to learn depends on
Definition
Developmental capability, age, physical n
Term
DENIAL OR DISBELIEF (Pt's behavior, learning implications and rational)
Definition
Patient avoids discussions of illness. Learning Implications - provide support, empath & careful explanation of all procedure while they are being done. Rational - patient is not prepared to deal with problem. An attempt convince or tell pt about illness will result in further anger or withdrawal. Provide only information pt pursues or absolutely requires.
Term
What do you do if the pt is angry?
Definition
Do not argue with patient, but listen to concerns. Patient needs opportunity to express feelings and anger. Patient is still not prepared to face future
Term
Bargaining
Definition
Pt offers to live better life in exchange for promise of better health. Continue to introduce only reality. Teach only in present tense. Patient is still unwilling to accept limitations
Term
Resolution
Definition
Patient begins to express emotions openly, realizes that illness has created changes and begins to ask questions. Encourage expression of feelings. Begin to share information needed for future and set aside formal times for discussion
Term
Acceptance
Definition
Patient recognizes reality of condition, actively pursues information and strives for independence. Focus teaching on future skills & knowledge required. Continue to teach about present occurrences. Involve family in teaching information for discharge. Pt begins to perceiver need for assistance and is ready to accept responsibility for learning. Pt is more easily motivated to learn.
Term
Teaching methods for Infants
Definition
keep routine, hold firm while smiling & speaking softly to convey trust; have them touch different textures
Term
Teaching methods for toddlers
Definition
Use play to teach procedure or activity, picture books that describe children in hospital or clinic, simple words
Term
Teaching methods for Preschooler
Definition
use role playing, imitation & play to make it fun, encourage questions & offer explanations. use simple explanations & demos, encourage children to learn together thru pics & short stories about how to perform hygiene
Term
Teaching methods for School Age Children
Definition
Teach psychomotor skills needed to maintain health, offer opportunities to discuss health problems & answer questions
Term
Adolescent
Definition
Help learn about feelings and need for self expression, use teaching as collaborative activity; allow to make decisions about health & health promotion (safety, sex ed, substance abuse)
Term
Young/Middle Adult
Definition
Encourage participation in teaching plan by setting mutual goals, encourage independent learning, offer information so that adult understands effects of health problem
Term
Teaching methods for Older Adult
Definition
Teach when alert & rested; involve adult in discussion or activity; focus on wellness & person's strength; use approaches that enhance reception of stimuli for pts with sensory alterations; keep sessions short
Term
Nursing Process
Definition
Assessment - Nursing Diagnosis - Planning - Implementation - Evaluation ANPIE anpie
Term
In the teaching process what areas are needed to assess?
Definition
Patient Expectations, motivation to learn, ability to learn, teaching environment, resources for learning, cultural considerations, health literacy
Term
Health Literacy
Definition
pt's reading & math skills, comprehension, ability to make health related decisions, & successful functioning as a consumer of health care
Term
Functional illiteracy
Definition
the inability to read about 5th grade level
Term
Nursing Diagnoses related to inability to learn
Definition
Ineffective health maintenance; deficient knowledge (affective, cognitive, psychomotor); Noncompliance (with medication); Ineffective self-health management; Impaired home maintenance; Ineffective family therapeutic regimen management
Term
Teaching approaches
Definition
Telling - useful when teaching limited info.
Participating - you & pt set objectives & participate together
Entrusting - provides the pt the opportunity to manage self care
Reinforcing - using a stimulus that increases the probability of a response
Term
Feedback is a common form of
Definition
Reinforcement
Term
Teaching Methods
Definition
1 on 1 discussion; group instruction; preparatory instruction; documentation; analogies; role playing; simulation
Term
Guidelines for Preparatory Instructions
Definition
1. Describe physical sensations during procedure, but don't evaluate them. 2. Describe the cause of the sensation, preventing false impressions of the experience 3. prepare pt only for aspects of the experience that have commonly been noticed by other pt.
Term
Analogies
Definition
add to verbal instructions by providing familiar images that make complex information more real & understandable. Know the concept, keep it simple & clear, & be aware of patients background, experience & culture
Term
Return Demonstration
Definition
the patient completes the procedure independently to show competence
Term
Effective teaching strategies for the older adult
Definition
individualized info based on what pt needs to know; present slowly in frequent sessions; include family; repeat frequently; reinforce with audiovisual, written exercises & practice; emphasize their concerns & past positive coping strategies; allow time to express themselves, demonstrate learning, & ask questions; establish measurable & realistic short term goals; establish follow up sessions; base new info on pts previous level of learning
Term
What do you document on patient education
Definition
1. assessment data & related nursing dx; 2. intervention planned & used; 3. Evaluation of Learning - "return demonstration of coughing" 4. ability of pt &/or family to manage care - identify need for outpatient or homecare follow up after discharge.
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