Term
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Definition
monobactam resistant to b-lactamases
Synergistic with aminoglycosides
Use for gram-negative rods |
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Term
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Definition
Binds ergosterol (same as Ampho B)
swish and swallow for oral candidiasis |
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Term
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Definition
Inhibits squalene epoxidase (like azoles)
SE: LFTs |
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Term
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Definition
Interferes with microtubule function; disrupts mitosis
Deposits in keratin-containing tissues (e.g. nails)
SEs: p450 induction, teratogenic, confusion |
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Term
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Definition
| Goes after p. vivax / ovale hiding in the liver. Prevents relapse (kills merozoites). |
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Term
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Definition
inhibits viral DNA polymerase - does not require activation.
SE: nephrotoxicity
- administer with probenecid |
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Term
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Definition
| NRTI - SE is pancreatitis |
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Term
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Definition
| inhibits HIV genome integration by reversibly inhibiting HIV integrase |
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Term
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Definition
| binds FK protein, inhibiting secretion of IL-2 and other cytokines |
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Term
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Definition
| inhibits mTOR. inhibits T-cell proliferation in re: to IL-2. |
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Term
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Definition
| antibody with high affinity for IL-2 receptor on T-cells |
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Term
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Definition
| precursor of 6-mercaptopurine, interferes with metabolism and synthesis of nucleic acids |
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Term
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Definition
| monoclonal ab to CD3 on surface of T cells |
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Term
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Definition
| recombinant IL-2 used in RCC and metastatic melanoma |
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Term
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Definition
| recombinant IL-11 used in thrombocytopenia |
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Term
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Definition
| Herceptin. Targets erb-B2 in Her-2 breast cancer |
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Term
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Definition
| Antibody to IgE used in severe asthma |
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Term
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Definition
| direct Ach agonist used to activate bladder and bowel |
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Term
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Definition
| (same as stigmines, edrophonium, donepezil) - AChE inhibitor used in glaucoma |
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Term
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Definition
| Muscarinic antagonist (like benztropine) |
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Term
| Oxybutynin, glycopyrrolate |
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Definition
| muscarinic antagonist (GU) |
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Term
| Pirenzepine, propantheline |
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Definition
| muscarinic antagonist (GI) |
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Term
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Definition
non-selective alpha agonist
Used for nasal decongestion, pupillary dilation |
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Term
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Definition
| nonselective beta agonist |
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Term
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Definition
| selective beta-2 agonist used to reduce uterine contractions |
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Term
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Definition
centrally acting alpha-2 agonist
Decreased TPR, decreased contractility
Used to tx HTN in pregx |
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Term
| Dopamine (low, medium, high) |
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Definition
Low dose - renal vasodilation
Med - Beta1 agonist
High - Alpha agonist |
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Term
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Definition
| selective alpha-2 blocker used in depression |
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Term
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Definition
| nonselective, irreversible alpha blocker |
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Term
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Definition
| nonselective, reversible alpha blocker |
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Term
| Which are the beta1 selective beta blockers? |
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Definition
ABEAM
Acebutolol
Betaxolol
Esmolol
Atenolol
Metoprolol |
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Term
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Definition
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Term
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Definition
inhibits monoamine xport in presynaptic n. terminals
allows MAO to chew up NE, 5HT, DA |
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Term
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Definition
| Dopamine D1 agonist to relax renal SM in setting of malignant HTN |
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Term
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Definition
| same as nitroglycerin - predominantly venous dilation to reduce preload |
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Term
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Definition
blocks cholesterol absorption
Decreases LDL, no other effect
Rare LFTs |
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Term
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Definition
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Term
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Definition
Phosphodiesterase 3 inhibitor --> increases cAMP
- increases contractility in heart
- arteriolar and venous dilation! |
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Term
| Tolbutamide, chlorpropamide |
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Definition
1st generation sulfonylureas
- disulfiram-like effect |
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Term
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Definition
| inhibits glucagon, used in DM2 |
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Term
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Definition
GLP-1 analog
- increases insulin, decreases glucagon release |
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Term
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Definition
ADH antagonist
- used in SIADH |
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Term
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Definition
D2 receptor antagonist
- increases resting tone, contractility, LES tone, and motility |
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Term
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Definition
PDE3 inhibtor, increases cAMP in platelets
- inhibits aggregation |
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Term
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Definition
SERMs
- antagonists in breast/uterus
- agonists in bone |
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Term
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Definition
| blocks bcr-abl tyrosine kinase |
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Term
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Definition
| inhibits reabsorption of uric acid in PCT |
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Term
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Definition
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Term
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Definition
| binds and stabilizes tubulin to inhibit polymerization - impairs PMN response to gout attack |
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Term
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Definition
| pegylated humanized monoclonal Ab against TNF-alpha |
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Term
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Definition
| increases outflow of aqueous humor in glaucoma |
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Term
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Definition
partial agonist at opioid mu
Agonist at kappa receptors |
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Term
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Definition
inhibits serotonin, NE uptake
Very weak opioid agonist |
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Term
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Definition
| selective MAO-B inhibitor |
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Term
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Definition
| used with sulfadiazine to tx toxo |
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Term
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Definition
selective alpha-1a inhibtor
Used in BPH, no risk of systemic hypoTN |
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Term
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Definition
Beta-2 agonist
Used to reduce premature uterine contractions |
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