Term
| These agents are primarly what type of blockers? |
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Definition
| Dopamine blockers - excess DA can cause psychosis. |
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Term
| First Generation Antipsychotics are Dopamine Blockers. |
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Definition
| Statement. Not a question. |
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Term
| What is the black box warning for all first generation antipsychotics |
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Definition
increase mortality in elderly patients with dementia - related psychosis, primarily due to increased risk of stroke |
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Term
| Describe, generally, EPS for 1st generation antipsychotics |
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Definition
all are sedating and all cause EPS, however the lower - potency agents have increased sedation and decreased incidence EPS (e.g. chlorpromazine), and the higher - potency agents have decreased sedation (but still sedating) with increased EPS (e.g. haloperidol). |
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Term
| Name the 1st generation antipyschotics |
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Definition
Chlorpromazine
Thioridazine
Loxapine
Perphenazine
Fluphenazine
Haloperidol
Trifluoperazine
Thiothixene
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Term
| Describe the movement disorders that first generations can cause. |
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Definition
Tardive dyskinesia (TD): facial movements. Higher risk in elderly.
Dystonias: prolonged contraction of muscles (including painful muscle spasms). Higher risk with younger males.
Dyskinesias: abnormal movements
Akathesia: restlessness with anxiety and an inability to remain still. |
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Term
| Cardiovascular Effects of first generation antipsychotics? |
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Definition
| Orthostasis, tachycardia, Qt prolongation. |
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Term
| What is the IM formulation of haloperidol used for? |
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Definition
| Decanoate (monthly): IM only, for conversion from PO, use 10 - 20x the oral dose. |
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