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19. The Cardiac Cycle
Clay Goodman
14
Biology
Graduate
09/26/2011

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Term
Phases of the Cardiac Cycle
Definition
1. Ventricular Filling
2. Ventricular Contraction
3. Ventricular Relaxation
Term
Active Ventricular Relaxation
Definition
Ventricular relaxation during diastole creates a suction effect that draws more blood into ventricle. Major contributor during exercise. Heart disease, hypertension, and pericardial disease may inhibit active ventricular relaxation. Atrial contraction may increase to compensate.
Term
Diastasis
Definition
Decrease of rate of flow from atria to ventricles in later stages of ventricular filling. This happens when the atrial and ventricular pressure are similar.
Term
Atrial contraction
Definition
Acts as a booster pump to augment ventricular filling, happens due to P wave.
Term
Valve Stenosis
Definition
Opening of valve creates an audible noise, should normally be silent.
Term
S3
Definition
Rapid flow of blood from atria to ventricles during ventricular filling may cause turbulent flow that is audible to auscultation. Physiologic, mostly seen in trained athletes, not pathological.
Term
S4
Definition
Pathological heart sound. Occurs when blood from the atria goes down the AV valves and hit an abnormally stiff ventricular wall. Sign of heart failure.
Term
Phases of Ventricular Contraction
Definition
1. Isovolumetric Contraction
2. Maximal Ejection
Term
Split S2
Definition
Caused by aortic and pulmonary valves closing at different times. Pulmonary valve closes later since it is in a lower pressure system. Have A2 sound first followed by P2 sound.
Term
Reason for aortic valve opening and closing at different pressures
Definition
When pulmonary valve opens, the CV system is at diastole (lower pressure). When aortic valve closes, system is at systole (high pressure).
Term
Factors affecting rapidity of ventricular ejection
Definition
1. Pressure gradient across aortic valve.
2. Elasticity of aorta.
Term
Symptoms of stiff aorta
Definition
1. Decreased systolic expansion and diastolic recoil.
2. Increased systolic blood pressure and decreased diastolic blood pressure.

A stiff aorta has less elasticity, which creates more pressure of aortic valve and causes it to open slower.
Term
Reduced ejection phase.
Definition
Sarcoplastic Reticulum actively takes up cytosolic Ca which causes myofibers in the ventricle to relax, reducing the rate of blood ejection. Signals beginning of ventricular relaxation.
Term
Regurgitant Valve
Definition
Blood flows back from aorta to the ventricle through a defective semilunar valve, causes regurgitant flow, resulting in a murmur (turbulent flow in heart).
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