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17 Nerve Cells and Synapses
powerpoint lecture
20
Biology
Undergraduate 1
03/07/2011

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Cards

Term
After a neurotransmitter is released, what three things can happen to it?
Definition

if it is in a hurry, it will diffuse out of the cleft

An active transport mechanism may suck it up into surrounding cells

Enzymes in the synaptic cleft may degrade it very quickly

Term
Schizophrenia
Definition
A nervous system disorder, 1% of the population suffers from it... have hallucinations and delusions...treatments for schizophrenia work by blocking receptors
Term
Alzheimer's Disease
Definition

not the same as dementia, it is a nervous system disorder

 

neurofibrillay tangles and amyloid plaques, you get a mutant form of Tau protein which causes unusual cytoskeleton structure building so axons don't go where they are supposed to 

Term
Parkinson's Disease
Definition

tremor of the limbs, nervous system disorder, dopamine dies prematurely

 

Can be treated by using L-DOPA which gets converted into dopamine... can't straight up use dopamine because it can't get across the blood-brain barrier 

Term
Out of the peripheral nervous system and the central nervous system, which one has the ability to repair itself?
Definition
the PNS
Term
How many times can cells divide?
Definition
an unlimited amount of times, except for cancer cells
Term

animals must defend themselves from many pathogens in the environment. What are the 3 R's that help them do this?

Definition

Reconnaissance

Recognition (difference between foreign things and things that belong there)

Response (ignoring the good stuff, killing the bad)

Term
What happens if innate immunity is not strong enough to fend off the pathogens?
Definition
the acquired immunity kicks in (it is slower and more specific)
Term
Pathogen
Definition
a disease causing organism, some are sophisticated and can get past the defences and reach acquired immunity
Term
Why is skin a barrier to viruses?
Definition

the outside of skin is dead cells and viruses can't survive in those cells. acidic enough to prevent colonization of many microbes

Skin includes proteins such as lysozyme which digests the cell walls of many bacteria

Term
Phagocytes
Definition

white blood cells!

They ingest invading microorganisms and stimulate the inflammatory response

Term
What happens when inflammatory response is stimulated?
Definition
Neutrophils and macrophages attach to their prey via the surface, engulf them, form a vacuole that fuses with a lysosome and then the phago-lysosome digests its contents
Term
What is a neutrophil
Definition
the only non-sex cell you can look at and see the sex of the person
Term
What is a macrophage?
Definition
a phagocytic cell that has protein receptors on its surface that recognize foreign things, they exist in tissues... when they are in blood they are called monocytes
Term
The complement system
Definition
has about 30 proteins involved in cascades that attach to the surface of foreign substances and punch holes in the their membranes. this makes foreign things more obvious to the immune system which helps to trigger inflammation
Term
Interferons
Definition

a family of proteins that cells make in response to viral infection, they turn off neighboring cells to make them unattractive to viruses,

involved in cancer defense

Term
Inflammatory response
Definition

injured cells release histamine 

o   Inflammation is a response to cell damage when blood vessels dilate and become leaky so they allow more fluid, phagocytes etc to beat them up            

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