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% of cardiac output that goes to major organs? |
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Definition
Kidney 25% Brain 15% Heart 5% |
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Term
How is diastolic filling time determined? How does it affect CO? |
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Definition
-determined by HR -CO increased up to 120-130 HR, then starts to dec due to inadequate filling time |
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Term
What is Preload directly related to? |
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Definition
LV end diastolic pressure (which is related to LV EDVolume) |
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effect of atrial contraction on LV EDV? |
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Definition
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Definition
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Anrep effect = Bowditch effect = |
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Definition
Inc myocardial contractility w/ ...inc afterload ...inc HR |
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Definition
greater the LVEDV, the greater the EF *up to a certain point* |
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Definition
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Definition
= CO x CaO2 x 10 *CaO2 = arterial oxygen content *CaO2 = [Hgb x 1.34 x O2 sat + (pO2 x 0.003)] |
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Definition
= CO x (CaO2-CvO2) CvO2 = venous O2 content |
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Term
what is the normal O2 delivery to consumption ratio? |
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Definition
4:1 (4x more O2 delivered than consumed) *25% utilized* *SvO2 = 75%* |
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Term
O2 Hgb curve -right vs left shift factors |
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Definition
1. right = O2 unloading -INC CO2, temp, ATP, 2-3DPG, H+ (dec pH) -methemoglobinemia 2. left = hang on to O2 -opposite above, fetal Hgb, CO poisoning |
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Definition
O2 at which 50% fo O2 receptors are saturated -27 mmHg |
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Term
most important determinant of myocardial O2 consumption? |
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Definition
Wall tension (next is heart rate) |
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Term
Bronchial blood flow -how does it affect blood pO2? |
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Definition
after supplying bronchus/lung tissue, empties into pulm veins.. -thus LV blood pO2 is 5 mmHg lower than pulm capillaries. |
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Definition
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Coronary sinus blood -what is the venous O2 saturation? |
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Definition
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Term
highest venous O2 saturation in body? |
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Definition
80% *receives 25% of CO but has low O2 extraction* |
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Term
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Definition
nail polish, dark skin, low CO, ambient light, low Hct, hypothermia, carbon monoxide |
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Term
PA cath distances to wedge? |
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Definition
R SVC 45 cm R IJ 50 cm L SVC 55 cm L IJ 60 cm (if much longer...either wrong place or has loop) |
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Term
optimal lung placement for PA cath? |
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Definition
Zone 3 (lower lobes) *less resp influence* |
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Term
when are wedge pressures taken? |
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Definition
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Term
sign that you are PA cath in correct place? |
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Definition
-appearance of dicrotic notch -inc in diastolic pressure |
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Term
absolute C.I. to PA cath placement |
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Definition
-right side endocarditis -right sided thrombus -right mechanical heart valve |
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Term
PEEP effect on wedge pressure? |
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Definition
IF PEEP over 10 -subtract 1/2 PEEP from wedge IF PEEP over 10 |
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Term
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Definition
CO 4-8 L/min CI = 2.5-4 L/min SVR = 8000-1400 (1100) wedge = 7-11 CVP 3-7 SvO2 = 75% +/- 5 |
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Term
Hemorrhagic shock -Dec vs Inc hemydynamic variables |
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Definition
Dec CVP/Wedge, SvO2, CI Inc SVR |
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Term
-Dec vs Inc hemydynamic variables Septis shock |
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Definition
Dec CVP/Wedge, SVR inc CI, SvO2 (hyperdynamic) |
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Term
-Dec vs Inc hemydynamic variables Cardiogenic |
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Definition
Dec CI, SvO2 Inc CVP/wedge, SVR |
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Term
-Dec vs Inc hemydynamic variables tamponade |
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Definition
Dec CI, SvO2 Inc CVP/wedge, SVR |
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Term
-Dec vs Inc hemydynamic variables Neurogenic shock |
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Definition
Dec SVR, CVP/Wedge, CI Inc SvO2 |
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Term
-Dec vs Inc hemydynamic variables Adrenal insuff |
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Definition
Dec: CVP/Wedge, CI, SVR, SVO2 |
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Term
-Dec vs Inc hemydynamic variables PE |
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Definition
Dec CI, SvO2 Inc CVP/Wedge, SVR |
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Term
initial response to hemorrhagic shock? |
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Definition
increased diastolic pressure |
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Term
common early sign just before clinical sepsis? |
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Definition
hyperglycemia early: impaired utilization late: insulin resistance |
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Term
cardiogenic shock w/high MAP -tx? |
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Definition
lasix to dec preload, pulm congestion, over-distension (which worsens contractility) |
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Term
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Definition
HypoTN JVD Muffled heart sounds |
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Term
First ECHO sign of tamponade? |
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Definition
impaired diastolic filling of RA |
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Term
how to be sure pericardiocentesis is pericardial blood? |
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Definition
pericardial blood does NOT clot |
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Term
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Definition
HypoTN, Bradycardia, warm extremities -dec SVR |
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Term
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Definition
1. give volume (CVP 8-12, wedge 16-18) 2. phenyl to raise SVR |
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Term
interp of ACTH stim test? |
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Definition
+ve cosyntropin test = 1. cortisol < 15 OR 2. change < 9 |
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Term
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Definition
-Dexamethasone + fludrocortisone *give these BEFORE stim test, as they don't interfere w/results* -Volume |
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Term
Relative potency of different steroids? |
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Definition
1x = cortisone, hydrocortisone 5x = prednisone, prednisolone, Me-pred 30x = dexamethasone |
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Definition
dexamethasone 30x cortisone |
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Definition
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possible sign of PE in intubated pt? |
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Definition
sudden dec in ET-CO2 -resp alkalosis due to tachypnea |
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Term
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Definition
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Term
% pts with PE that have negative LE duplex? |
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Definition
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Term
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Definition
80 u/kg bolus 18 u/kg/hr gtt |
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Term
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Definition
vasoconstrict gluconeogen, glycogenolysis (phospholipase medatied) |
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Term
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Definition
venous vasoconstrictor (dec cAMP = dec Ca) |
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Term
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Definition
inc contractility inc HR (inc cAMP mediated) |
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Term
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Definition
vaso/bronchodilat inc glucagon, renin (cAMP mediated) |
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Term
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Definition
inc renal blood flow ?inc splanchnic flow? |
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Term
Vasopressin receptor location/effects? |
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Definition
V1 = vascular smooth muscle, constriction V2 = collecting ducts, water resporption V3 = endothelium, F8 and vWF release |
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Term
Nitric oxide precursor? -mech? |
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Definition
Arginine (nitric oxide synthetase) NO acts on guanylate cyclase to in cGMP ==>dilation of BV |
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Term
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Definition
1. blocks angiotensin 2 formation --> dec BP, dec aldost, dec Vaso release |
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Term
prostacyclin vs endothelin receptor on pulm function? |
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Definition
prostacyclin = pulm vasodilation
Endothelin = pulm vasoconstriction |
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Term
inotropes that direclty inc cAMP |
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Definition
Dopamine Dobutamine Epi Isoproterenol |
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Term
Dopamine effect based on dose (mcg/kg/min) |
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Definition
Low = 1-5 = DA receptors mid = 6-10 = beta 1+2 (contractility, HR) high = >10 = alpha-1 vasoconstrict |
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Term
Dobutamine -receptor target? |
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Definition
Beta-1 (contractility) *some beta 2 (dilation) at high dose >15* |
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Term
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Definition
-PDE inhibitor (inc cAMP = inc Ca) *also vasodilator* |
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Term
good inotrope for long-term use? |
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Definition
Milrinone -not subject to beta-receptor down-reg |
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Term
isoproterenol -receptor targets -SE? |
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Definition
Beta 1+2: inc HR, contractility + V.dilate
SE = Arrhythmogenic, inc heart metabolic demand. might actually dec BP via B2 |
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Term
which pressors are also inotropes? |
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Definition
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Term
phenylephrine receptor target |
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Definition
alpha 1 (vasoconstriction) |
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Term
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Definition
alpha 1 + 2 some beta 1 *potent splanchnic vasocosntrictor* |
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Term
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Definition
low dose (1-5 mcg/min) = Beta 1+2 high = >5 = alpha 1+2 *at low doses..beta 2>1 = lowers BP* |
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Term
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Definition
arrhythmogenic high O2 demand low doses: Beta 2>1 = hypotension |
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Term
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Definition
V1 receptors -0.01-0.1 U.min = vasoconstriction |
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Term
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Definition
-NO mediated vasodilation (arterial>>>venous) |
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Term
nipride cyanide toxicity risk factors? -what labs to get/characteristic results? -pphys |
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Definition
-nipride > 3 ug/kg/min x 72 hrs -get gas (met acid), thiocyanate level -Inc SVO2 (L->R shunt) due to ETC disruption (cyanide binds cytochrome C) |
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Term
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Definition
Amytl nitrite f/b sodium nitrite |
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Term
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Definition
NO mediated venodilation (minimal arterial) -dec myocardial wall tension 2/2 dec preload |
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Term
benefits of ACE-I post MI? |
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Definition
dec mortality dec CHF development |
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Term
ACE-I absolute contraindications |
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Definition
hx angioedema renal artery stenosis |
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Term
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Definition
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Term
fenoldopam -receptor target -effect |
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Definition
DA-1A receptor -art vasodilator (w/reflex tachy) |
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Term
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Definition
1st = alpha 1 blk 2nd = beta 1 block, beta-2 agonist *dec MAP w/out altering HR/CO* |
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Term
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Definition
pulm vasodilation -blocks endothelin |
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Term
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Definition
NO mediated pulm vasodilation (soluble guanylate cyclase) |
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Term
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Definition
inflation on T wave (diastole) deflation on P wave/start of Q wave (systole) |
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Term
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Definition
just distal to left Subclav artery |
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Term
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Definition
1. inc MAP (inflates during ventric diast) 2. inc coronary perfusion (Coronarys fill in diastole) 3. dec afterload (deflates during sys) |
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Term
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Definition
1. cardiogenic shock s/p MI 2. vent septal ruptuer 3. acute MR (ex rupt. pap m) 4. USAngina 5. pre-op cardiac surg w/low EF |
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Term
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Definition
aortic regurg aortic dissection severe AI occlusive DZ (relative CI = aortic graft, aneurysm) |
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Term
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Definition
-meds: amio, fluoroquinolones, others -lytes: hypoMG |
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Term
cardiac sugery post-op a-fib -% in sinus by 6 week? |
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Definition
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Term
Afib -AC and cardioversion rec? |
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Definition
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Term
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Definition
epi 1 mg vaso 40 units amio 300 mg (150 mg 2nd dose) ----- atropine 1 mg |
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Term
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Definition
Hypovolemia, hypoxia, H+, Hypo/HyperK, Hypothermia
Tension ptx, Tamponade, Toxins, Thrombosis (PE), Thrombosis (coronary) |
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Term
Good initial step vs PEA? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
Epicardial pacer nomenclature->what each letter means |
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Definition
1st letter = which chamber is paced 2nd = which chamber is sensed 3rd = response to sensed beat |
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Term
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Definition
D = dual senses both, paces both, inhibits/triggers * i = just inhibits* |
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Term
epicardial pacers -myopotential inhibition = |
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Definition
-sensitivity too high (picking up background noise) -->turn sensitivity down **pacing too much = sensitivity too low = turn it up*** |
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Term
Which renal limb controls GFR? |
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Definition
efferent (leaving glomerulus) |
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Term
what causes renin release? |
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Definition
-dec pressure (sensed by JGA) -inc Na (sensed by macula densa) *others: beta 2 stim, hyperK* |
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Term
inhibition of renin release? |
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Definition
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Term
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Definition
convert angiotension to angiontensin 1 *angiotensin synth in liver* |
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Term
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Definition
-lung -convert ang I-->ang II *also breaksdown bradyK* |
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Term
angiotensin II -primary vs secondary effects |
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Definition
-primary: aldost release from adrnl cortex -2ndry: vasocontrict, inc symp tone, ADH release |
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Term
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Definition
1. activate Na/K ATPase @ DCT = Na/water reab + K excretion 2. activate Na/He xchanger->H+ excretion -->met alkalosis |
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Term
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Definition
collecting ducts (water reab) |
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Term
ANP -mech of release -effects |
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Definition
atrial distension (vol overload) = release from atrial wall -inhib Na/water reab @ CD -vasodilate -inhib renin/aldosterone production |
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Term
mech of kidney injury from.. 1.NSAID 2.Aminoglycosides 3.dye 4.myoglobin |
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Definition
1. --|prostaglandin = arteriole v.constrict 2-4. direct tubule injury |
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Term
mech of kidney injury from.. 1.NSAID 2.Aminoglycosides 3.dye 4.myoglobin |
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Definition
1. --|prostaglandin = arteriole v.constrict 2-4. direct tubule injury |
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Term
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Definition
hct inc 5-8 per liter taken off |
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Term
Contrast dye prep protocol |
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Definition
1. HYDRATE (most protective measure) 2. N acetylcysteine (600 PO BID day before) 3. bicarb gtt (1 hr before-->6 hr after) 4. Hold ACE/ARB/NSAIDs/diuretics 5. minimize contrast vol, use isosmolar soln |
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Term
cause of MRI induced renal fail? |
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Definition
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Term
mech of myoglobin toxicity? tx |
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Definition
1. converted to renal toxic metab ferrihemate in acidic env *tx bicarb gtt (alkalinize urine) + IVF* |
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Term
IVF to avoid in chronic renal failure? |
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Definition
LR (has too much K) *use NS* |
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Term
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Definition
= Urine Na/Cr / plasma Na/Cr (ratio of urine to plasma Na/Cr) |
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Term
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Definition
Pre-renal = < 1 %
Renal = > 2% |
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Term
labs suggesting pre-renal etiology/ |
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Definition
FeNa<1% Urine Na < 20 BUN/Cr > 20 Urine osm > 500 mOsm (concentrated) |
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Term
MCC renal ATN in peri-op settings? |
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Definition
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Term
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Definition
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Term
MCC.. -poor post-op UOP -post-op ARF |
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Definition
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Term
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Definition
total lung capacity = FVC + RV |
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Term
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Definition
Forced vital capacity -vol of air w/max exhalation after max inhalation |
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Term
Residual volume = what % of lung volume does it account for? |
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Definition
vol after max expiration = 20% of lung volume |
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Term
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Definition
functional residual capacity = lung vol after normal exhale = ERV + RV |
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Term
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Definition
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Term
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Definition
exp reserve vol = volume of air expired AFTER normal expiration |
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Term
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Definition
vol of air inhaled after normal exhale |
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Term
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Definition
forced exp vol in 1 second after max inhale |
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Term
minute ventilation equation = |
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Definition
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Term
lung compliance equation = |
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Definition
change in lung vol/change in lung pressure |
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Term
area of highest V/q ratio? |
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Definition
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Term
dead space definition -normal vol? |
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Definition
lung that is ventilated but not perfused -150 cc |
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Term
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Definition
-dec Cardiac output = capillary collapse -PE, pulm HTN, ARDS (cap compression) -Excessive PEEP (cap compessed) |
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Term
reflection of inc dead space on labs? |
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Definition
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Term
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Definition
poor ventilation but GOOD perfusion |
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Term
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Definition
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Term
Lung volumes -restrictive vs obstructive pattern |
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Definition
Restrictive: dec TLC, RV, FVC
Obstructive: Inc TLC, RV. Dec FEV1 |
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Term
Lung volumes Changes w/obesity? |
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Definition
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Term
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Definition
hypoxia acidosis histamine, serotonin, thromboxane epi, NE |
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Term
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Definition
nipride, nitroglycerin, nifedipine -->manifests as hypoxia |
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Term
Normal IE ratio? -vent changes w/ARDS? |
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Definition
1:3 inc I time with ARDS to improve oxygenation |
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Term
pphys of fever w/atelectasis? |
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Definition
IL-1 release from pulm macrophages |
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Term
how does inc PEEP increase oxygenation? |
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Definition
by improving FUNCTIONAL RESIDUAL CAPACITY *better at improving pO2 than inf FiO2* |
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Term
FiO2 goal to dec O2 radical tox?> |
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Definition
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Term
hemodynamic effects of inc PEEP? |
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Definition
dec CO 2/2.. dec RA filling inc pulm vascular resistance ->dec LA filling |
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Term
how does pressure support work? |
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Definition
dec work of breathing -inspiratory pressure held constant until minimum tidal volume met |
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Term
how to prevent barotrauma? |
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Definition
keep plateau pressure < 30 (most impt) keep peak pressure < 50 |
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Term
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Definition
1. neg insp force > 20 2. FiO2 < 40, PEEP 5, PS 5 3. Rapid shallow breathing index < 105 *RR/TV* *>105 -->95% fail* |
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Term
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Definition
MePred 20 mg IV q 12 before ext -check for airleak |
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Term
preload changes with mechanical ventilation? |
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Definition
inspiratoin = dec BP 2/2 dec venous return -SVC + IVC compression (dec RA return) -pulm cap compression (dec LV preload) **OPPOSITE OF NORMAL PHYSIO** |
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Term
common scenario for use of high freq ventilation? |
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Definition
in peds.. TE fistula, BP fistula |
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Term
|
Definition
1. parenchymal damage/small airway collapse -->air trapping 2. chronic bronchitis |
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Term
tx found to inc COPD survival long term? |
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Definition
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Term
|
Definition
interruption of expiration before alveolar pressure falls to pATM |
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Term
|
Definition
RV hypertrophy/dysfunction -cor pulmonale |
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Term
normal % of VO2 accounted for by work of breathing? |
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Definition
|
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Term
|
Definition
-O2, nebs, inhaled steroids +/- PO/IV -amoxicillin -NIPPV |
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|
Term
best esophagectomy approach in pt with bad COPD? |
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Definition
trans-hiatal -avoid thoracotomy |
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Term
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Definition
direct: pna 40%, asp 15% indirect: MCC sepsis |
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Term
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Definition
1. acute 2. bilateral diffuse patchy CXR 3. Wedge < 18 4. PO2/FiO2 < 300 |
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Term
|
Definition
-proteinaceous exudate (not diagnostic) |
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Term
|
Definition
increase I time -increases oxygenation at expense of PERMISSIVE HYPERCAPNEA |
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Term
|
Definition
pH>7.3 PO2 > 60, Sat > 92 permissive hypercapnea tidal vol 6-8 cc/kg P plateau < 30 |
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Term
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Definition
new infiltate, Fever, purulent sputum *>48 hrs on vent* |
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|
Term
-Mediators of SIRS? -most potent SIRS stimulator? |
|
Definition
TNF-alpha, IL-1 *GNR endotoxin (lipid A portion of lipopolysaccharide) = most potent stimulator** |
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|
Term
most potent TNF alpha trigger? |
|
Definition
Lipid A portion of LPS endotoxin |
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Term
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Definition
Mill wheel murmur sudden dec ET-CO2, hypoTN, tachy |
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Term
|
Definition
trendelenburg, left lateral decub (keep it in right heart) - |
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Term
|
Definition
-petechiae, hypoxia, AMS -sudan red stain: fat in sputum, urine |
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Term
|
Definition
LE fx/ortho surg -hip/femur |
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|
Term
MC timing of ICU delirium ? |
|
Definition
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|
Term
factors that preclude brain death dx? |
|
Definition
-Uremia -Temp <32 -hypoTN < 70/40 -desat w/apnea test -drugs/meds/metabolic issues |
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|
Term
requirements for brain death dx? |
|
Definition
-2 physician exams -silent EEG -MRA with no flow -6 to 12 hours of... 1. no pain response 2. no cold oculovestibular reflex 3. no oculocephalic reflex (dolls eye) 4. +ve apnea test 5. no corneal reflex 6. no gag reflex 7. fixed, dilated pupils |
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|
Term
how to perform/interp apnea test? -when to terminate test? |
|
Definition
1. Pre-oxygenate, then disconnect from vent 2. +ve if CO2>60 OR inc bhy 20 **terminated if Psys<60 or desat** |
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|
Term
exam finding still +ve with brain death? |
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Definition
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|
Term
Abd compartment syndrome bladder pressure/ |
|
Definition
|
|
Term
|
Definition
needle shaped negatively birifringent crystals |
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|
Term
|
Definition
-acute: indomethacin, cochicine, naproxen, steroids - |
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Term
QT interval -normal values vs abn/ |
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Definition
-prolonged= >440ms men, >460ms in women *QTc> 500 = inc risk of torsades *QTc is abn short if < 350ms |
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|
Term
PPhys of carbon monoxide poisoning/ |
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Definition
CarboxyHgb has 250x affinity for Hgb vs O2 =left shift @ dissociation curve |
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Term
Carbon monoxide poisoning -dx tx |
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Definition
-falsely elevated sat -carboxyHgb levels >10% (>20% in smokers) *tx = 100% O2 +/- hyperbaric O2* |
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Term
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Definition
1. O2 carrying Fe2+ (ferous) 2. oxidized to Fe3+ (ferric) = methemoglobin ==>right shift = O2 cant bind |
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Term
Methemoglobinemia 1. causes 2. sxs 3. tx |
|
Definition
1.causes: benzocaine (hurrcaine spray), dapsone, fertilizers *ALL = OXIDIZING AGENTS* 2. low O2 sat of 85% 3. O2 + MeBlue (1mg/kg-->restores Fe to ferrous/reduced state) |
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Term
Critical illness polyneuropathy -sxs -rf -clinical sig in ICU |
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Definition
-motor>sensory -RF = ARDS, sepsis, steroids, SIRS, paralytics, hyperglycemia *can -->diffiuclty weaning* |
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|
Term
enzyme that forms O2 radicals? |
|
Definition
xanthine oxidase -endothelial cells *normally metabolized purines->uric acid* |
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|
Term
physio variables inc w/CO2 pneumoperitoneum? |
|
Definition
-pulm art pressure, pulm vasc resistance -HR -SVR, VCP, Mean airway presure, PIP, -CO2 (can dec contractility) |
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|
Term
physio variables dec w/CO2 pneumoperitoneum? |
|
Definition
-pH, venous return, renal flow -cardiac output |
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Term
|
Definition
B mode = brightness (assess relative density) Duplex = B mode + doppler |
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Term
|
Definition
lower freq = deep structures, less resolution |
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|
Term
Harmonic scalpel -how it works? |
|
Definition
disrupt protein hydrogen bonds |
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Term
Argon beam -mech? -good use? |
|
Definition
causes superficial coagulation -is non-contract-->use for liver/spleen |
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Term
|
Definition
0.5 mm (wear mask if used vs condylomata ccuminata) |
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|
Term
incidence of injury w/Verres? |
|
Definition
|
|
Term
Gortex vs Dacron -major difference/ |
|
Definition
Gortex DOES NOT allow fibroblast in-growth *Dacron Does* |
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|