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14: Neurological Disorders
14: Neurological Disorders
31
Physiology
Undergraduate 4
12/06/2011

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Term
Malignant tumor
Definition
Cancerous tumor that causes harm
-has not distinct border
-might metastasize
Term
Benign tumor
Definition
Noncancerous tumor that does no harm
-has a distinct border
-cannot metastasize
Term
What causes tumors?
Definition
Any cell that can replicate
-NOT neurons!
Term
Metastasis
Definition
Process by which cells break off of a tumor
-cells travel through the vascular system and grow somewhere else in the body (how cancer spreads)
Term
Glioma
Definition
Brain tumor made of glial cells
-cancerous
Term
Mengioma
Definition
Tumor composed of the cells in the meninges
-benign
Term
What causes a seizure disorder?
Definition
-Too much glutamate
-Too little GABA
Term
Status epilepticus
Definition
Condition in which a person has a series of seizures without regaining consciousness
Term
Need to know
Definition
3:3-4
4:2-4
5:3-5
Term
Hemmorhagic stroke
Definition
A cerebrovascular accident caused by the rupture of a cerebral blood vessel
Term
Obstructive stroke
Definition
A cerebrovascular accident caused by blockage of a blood vessel
Term
Ischemia
Definition
The interruption of the blood supply to a region of the body
Term
Thrombus
Definition
A blood clot that forms in a blood vessel
-might block it
Term
Embolus
Definition
Something (such as a blood clot or fat) that dislodges from its original place and blocks an artery
Term
What can an embolus lead to if it is in the brain?
Definition
Stroke
Term
What is the difference between a partial and generalized seizure?
Definition
-Partial: begins and remains localized in one region of the brain
-Generalized: involves most of the brain
Term
Complex partial seizure
Definition
A partial seizure that produces loss of consciousness
Term
Grand mal seizure
Definition
A generalized seizure that results in a convulsion
-tonic-clonic
Term
Tonic phase
Definition
First phase of a grand mal seizure
-muscles are contracted
Term
Clonic phase
Definition
Phase of a grand mal seizure
-rhythmic jerking movements (release of muscle contraction)
Term
Absence
Definition
Periods of inattention/immobility
-not remembered
-aka petit mal seizure
Term
Transmissible Spongiform Encephalopathy
Definition
Contagious brain disease that makes the brain spongey
Term
What causes Transmissible Spongiform Encephalopathy?
Definition
Accumulation of misfolded prion protiens
Term
Caspase
Definition
"killer enzyme" that plays a role in programmed cell death
-may be activated by misfolded prion
Term
Parkinson's disease
Definition
-Muscular rigidity
-Tremors
-Problems with initiating/stopping movement
Term
What causes Parkinson's disease?
Definition
Destruction of nigrostriatal DA neurons
Term
Huntington's disease
Definition
Inherited disorder that causes degeneration of the basal ganglia
-Jerking movements
-Dementia
-Death
Term
Amyotrophic Lateral Sclerosis
Definition
Disorder that attacks the spinal cord and cranial nerve motor neurons
-increased tension of muscles
-muscular atrophy
-paralysis

-aka Lou Gehrig's Disease
Term
Muscular Sclerosis
Definition
Autoimmune demyelinating disease that causes scleroses
-lack of coordination
-bowel/bladder control issues
-severe pain
Term
Encephalitis (what it is and what causes it)
Definition
An inflammation of the brain
-caused by bacteria, viruses, or toxic chemicals
Term
Meningitis (what it is and what causes it)
Definition
Inflammation of the meninges
-caused by viruses or bacteria
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