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| after sperm hits egg/last period to birth |
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| age after birth plus age when sperm hit egg/last period |
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| Weak bases effect absorbtion |
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Definition
| increase oral bioavailabilty (penicillin) |
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Definition
| decrease bioavailability (phenobarb) |
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| Topical compounds absoprt |
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| Neonates total body water |
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| The young have_______VD and ______Protein binding |
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Definition
increased VD
Decreased Protein binding |
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Definition
| protein binding displacement >>> bilirubin |
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| SUlfonamides have risk of |
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| Hepatic activity at birth |
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Definition
-only 60-70%
-decreased bilirubin excretion
- |
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Definition
| decreased until 3 years old |
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| Drugs affected by development alterations |
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Definition
MAT
Morphine, APAP, Theophylline
(also phenytoin,phenobarb,chloramphenicol) |
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Definition
Neonate = 30 hrs adult = 6hrs
-Neonates theophylline to cafeine by N-METHYLATION
-Adults theophylline to methyxanthine&methyluric acid by OXIDATION |
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Definition
| Gray baby syndrome due to inc serum conc bc baby cannot do glucuronidation |
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| Renal blood flow at birth= |
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Definition
DECREASED
(also tubular secretion, reabsorption,gfr) |
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| Drugs affected by kidney function in peds |
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Definition
| Aminoglycs, vanco,chloramphenicol =GFR Penicillins,Sulfaonamides,Furosemide= Tube secr Nonionized weak acids/bases = Tube reabsorb |
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Definition
CrCl = K x L/SCr
k=constant of proportionality
l=length in cm |
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Term
RDS
Respiratory distress syndrome Tx |
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Definition
Corticosteroids
-Betameth or Dexamethasone for 2 days
-Surfactant replacement w/ Beractant,Calfactant, Poractant
O2, supportive care |
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Term
| Neonatal apnea is associated with |
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Definition
stop breath for 15+ secs
-Hypoglycemia
-Anemia
-Electrolyte
-Seizures
-intracranial bleeds |
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Term
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Definition
-Supp O2
-Head/neck position correction
-sepsis?
-meds |
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Definition
Theophylline/Aminophylline
Caffeine citrate (more specific/more reliable absorp) |
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| Theophylline/Aminophylline adverse eFX |
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Definition
-Gi irritate,hyperglyc
-CNS irrit/Narrow therapeutic index
-tachycard,vomit, & seizr at toxic dose |
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Definition
first 72 hrs of life
-Group B strep, listeria , e coli
-mom's gi tract or amniotic fluid is culprit |
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Term
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Definition
> 72 hrs after birth
-Group B strep,s aureus , e coli
-culprit is external (iv,catheters) |
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Term
| Neonatal Sepsis screening |
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Definition
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Definition
amp + gent
or
amp + cefotaxime |
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Definition
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| Must rule out _____ in Neonatal Sepsis |
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Definition
Meningitis
(lumbar puncture)
:( |
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Definition
AFTER 1 year of age
(breast milk is best) |
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| Vitamin D recommended in Infants RDA |
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Definition
400 units daily
childran and adolescents = 600 units |
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| Delay Hep B vaccines when |
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Definition
| Infants <2kg. wait till they turn 1 mnth |
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Definition
Irritability:
-Risperidone (5+years), Aripiprazole(6+yrs old) |
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Term
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Definition
APAP: 10-15mg/kg/dose q 4-6 h
IBU: 5-10mg/kg/dose q 4-6 h
Ketorolac: 0.5mg/kg/dose q 6 h
Naproxen: 5-7 mg/kg/dose q 8-12 h |
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Term
| OPIODS recommended in PAIN Peds |
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Definition
Morphine
Methadone
Fentanyl
Hydromorphone |
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Term
| Tetracyclines issue in children |
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Definition
-dental staining/teeth defects
-dec bone growth
-CONTRA in pregnancy, nursing moms, & young children |
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Term
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Definition
-Arthropathy(joint inflamm)
erodes cartilage
-use w/ caution |
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Term
| ________ is a drug that is displaced by bilirubin and will have higher drug levels? |
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Definition
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| Leading cause of death in premature infants? |
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Definition
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Term
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Definition
| Retractions, grunting, and nasal flaring |
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Term
| Which vaccines are given at 2, 4, and 6 months of age with a booster at 12-15 months? |
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Definition
| RV (no booster), DTaP, Hib, PCV, IPV (2,4, booster at 6-18mo) |
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Term
| Given at 12-15 months of age with a booster at 4-6 years old? |
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Definition
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| Given at 1-2 years of age? |
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Definition
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| SSRIs with most evidence for autism? |
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Definition
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