Term
| cutaneous manifestations of neurologic/psychiatric disease |
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Definition
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Term
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Definition
-monosymptomatic hypochondriacal disease
-false belief that an individual is infected with a parasite
-sensation of biting, stinging, or crawling (important to distinguish this from substance abuse)
-"ziploc bag" sign
-antipsychotics |
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Term
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Definition
| symptom of depression - self mutilation |
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Term
| cutaneous manifestations of cardiovascular disease |
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Definition
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Term
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Definition
petechiae
splinter hemorrhages
Osler nodes
Janeway lesions
Roth spots |
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Term
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Definition
present as macules
common but nonspecific |
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Term
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Definition
| red linear lesions in the nailbeds |
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Term
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Definition
| PAINFUL subcutaneous nodules, typically at the distal pads of fingers and toes |
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Term
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Definition
| NON-TENDER red macules on the palms and soles |
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Term
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Definition
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Term
| cutaneous manifestations of pulmonary disease |
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Definition
| sarcoidosis (lupus pernio) |
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Term
| sarcoidosis (lupus pernio) |
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Definition
papulonodules and plaques affecting areas affected by cold temperature
often presents with a beaded appearance of papules along the nasal rim
strongly associated with chronic pulmonary and upper resp tract sarcoidosis |
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Term
| cutaneous manifestations of GI disease |
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Definition
neutrophilic dermatoses:
-pyoderma gangrenosum
-Sweet's syndrome |
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Term
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Definition
neutrophilic dermatoses associated with IBD
-inflammatory process with rapidly expanding, painful ulcerations with undermined violaceous borders
-aseptic, but can be secondarily infected
-associated with lymphoreticular malignancies and inflammatory bowel disease
-pathergy |
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Term
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Definition
| new lesions occuring at sites of trauma - ie wounds, needlesticks |
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Term
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Definition
"Acute febrile neutrophilic dermatosis"
neutrophilic dermatoses associated with IBD
-brightly erythematous papulo-nodular lesions with pseudovesiculation
-neutrophils fill dermis
-episodic fevers, elevated WBC, increased ESR
-pathergy
-responsive to prednisone |
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Term
| cutaneous manifestations of renal disease |
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Definition
| nephrogenic systemic fibrosis |
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Term
| nephrogenic systemic fibrosis |
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Definition
-very FIRM plaque
-debilitating progressive skin and joint fibrosis with secondary impairment of functioning and mobility
-fibrosis ma affect diaphragm, heart, lungs, kidneys
-only seen in patients with kidney failure
-strongly associated with gadolinium-containing MRI contrast agents |
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Term
| cutaneous manifestations of nutritional deficiency |
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Definition
| acrodermatitis enteropathica |
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Term
| acrodermatitis enteropathica |
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Definition
zinc deficiency
-dry, scaly, eczematous patches and plaques with vesiculobullous or erosive lesions at periorificial and acral (distal) sites
-associated alopecia, diarrhea
-low serum zinc, anemia, low alkaline phosphatase |
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Term
| causes of aquired acrodermatitis enteropathica |
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Definition
-dietary zinc deficiency
-lack of GI absorption (bowel bypass or enteropathy)
-TPN
-nephrotic syndrome
-parental deficiency in breast fed infant |
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Term
| cutaneous manifestations of infectious disease |
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Definition
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Term
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Definition
associated with human herpes virus 8
purple painless plaques, increasing in size |
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Term
| cutaneous manifestations of hematologic disease |
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Definition
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Term
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Definition
bright purple nodules that can develop during chemotherapy treatment
multifocal soft pink to flesh colored papules
can be primary cutaneous or metastatic |
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Term
| cutaneous manifestations of endocrine disease |
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Definition
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Term
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Definition
-diffuse velvety thickening and hyperpigmentation
-typically in axilla, neck, other body folds, dorsum of hand (over knuckles)
-epidermal overgrwoth may be related to increased IGF-1 receptor stimulation of keratinocytes in a hyperinsulinemic state |
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Term
| associates with acanthosis nigricans |
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Definition
-OBESITY is most common
-endocrine (insulin resistance, acromegaly, Cushing's, Addison's)
-familial
-drug induced
-malignancy (very rare)
-idiopathic |
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Term
| cutaneous manifestations of internal malignancy |
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Definition
cutaneous metastases
paraneoplastic phenomena |
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Term
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Definition
~10% of all metastasis
-often the first sign of extranodal spread
-commonly from: BREAST, upper aerodigestive tract, lung, skin
-firm papules/nodules that are often bound down, +/-ulceration |
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Term
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Definition
hypertrichosis lanuginosa acquisita
Bazex syndrome
erythema gyratum repens
paraneoplasic pemphigus |
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Term
| hypertrichosis lanuginosa acquisita |
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Definition
downy white hair
associated with LUNG, breast, uterine, colorectal, lymphoma, and bladder malignancies |
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Term
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Definition
"Acrokeratosis paraneoplastica"
acral (distal site) psoriasiform plaques, typically involving nose and helices
often associated with upper aerodigestive tract malignancy (pharynx, larynx, esophagus) |
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Term
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Definition
concentric eryhtematous plaques, often associated with polycyclic arrangement that gives a "wood-grain" appearance
classically associated with lung cancer |
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Term
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Definition
severe mucosal erosions and ulcerations
mediated by autoantibodies against epidermal proteins |
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