cannabis

Cannabis sativa

Sativex (brand botanical drug, buccal spray);mix of 2 sativa extracts

approved in Canada (another reason to go!)

(+) nuero pain from MS

nabilone (synth derivative): delta-9 THC

US approved

(+)antiemetic

2016 new law bypass fda approval for medical marijuana

Medical Marijuana Commision - 14 members, 2 Pharmds

Betal Quid

Areca catechu

a chew from dried fruits (mixed w calcium oxide) used ethnomedicinally for "well being"

if consumed (-): oral submucous fibrosis, cant open mouth, malignant when combined w tobaco

Arecoline: (+) veterinary vermicide

China, Taiwan

Khat

Catha edulis

cathinone (similar to amphetamine)

(+)social drug in E. africa, decrease hunger

(-)HTN, insomnia, dependence

Ethiopia & Djibouti

MCAT

miaow miaow

mephedrone

MCAT:mephedrone:(-)5ht2b receptor affinity due to keto side chain that produces planarity

Bubbles: methylone(similar structure to MCAT): patented in US as antidepressant

Kratom

Mitragyna Speciosa

Rubiacaea (coffee family)

(+)opium like effects, withdrawl symptoms (mu & kappa affinity, high doses), withstand fatgue (low doses)

leaves smoked, chewd, or tea

Mitragynine-indole alkoloid

DEA: temporary scheduled 1 narcotic

Thialand

Peyote buttons

Lophophora williamsii

mescaline: photoalkaloid

legal in native american church

(+)mydriasis, weird colors, dorwsiness, sleep

mexico

Fly agaric

Amanita muscaria

mushroom: sold as pot pourrii siberia

(+) hallucinogen, colors, sleepiness (small doses: 1-4 mushrooms), spasms and vivid hallucinogen (5-10 mushrooms)

Ibotenic acid & muscimole

type of sage

(+)kappa opioid effects, hallucinations (second potent next to LSD)

legal and sold thru internet in US

Salvinorin A

mexico

Jimsonweed seeds

Datura stramonium

mushroom

tropane esthers: atropine & hyoscine (scopalamine)

(+)hallucinogen

(-)inability to urinate, thirst, convulsions

child lethal dose of seeds 4-5g

midwest

Δ9-trans-tetrahydrocannabinol (Δ9-THC) & cannabidiol

From: Cannabis sativa (Marijuana; Cannabis)

Arecoline

From: Betel Quid

Arecoline has medicinal use as a veterinary vermicide.

(-)-Cathinone

From: Khat

(-)-cathinone, a keto analog of (+)-amphetamine

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Mephedrone

Has affinity for the 5HT2B receptor, leading to potential toxicity

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Methylone

Antidepressant from a U.S. academic laboratory.

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Mitragynine

From: Kratom leaves

Acts at the mu- and kappa-opioid receptors with high
affinity

The U.S. Drug Enforcement Administration (DEA) has stated their intention to effectively ban kratom by temporarily classifying mitragynine and 7-OH-mitragynine as Schedule 1 narcotics.

Mescaline (3,4,5-trimethoxy-β-phenethylamine)

From: Lophophora williamsii (Peyote buttons)

Ibotenic acid & Muscimole

From: Amanita muscaria (Fly agaric)

Ibotenic acid and muscimole are responsible for most of the symptoms

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Salvinorin A

From: Salvia divinorum (neoclerodane diterpenoid)

Binds potently and selectively to the kappa opioid receptor